Acetic acid and butyric acid released in large intestine play different roles in the alleviation of constipation

Wang, Linlin; Cen, Shi; Wang, Gang; Lee, Yuan‐Kun; Zhao, Jianxin; Zhang, Hao; Chen, Wei

doi:10.1016/j.jff.2020.103953

Cited by 69 publications

(47 citation statements)

References 32 publications

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“…Furthermore, butyric acid can also inhibit inflammatory responses by regulating monocyte differentiation via HDAC inhibition and reducing macrophage activity [ 41 ]. An increase in the SCFA concentration in the intestine also effectively reduces the risk of constipation and colorectal cancer [ 73 ]. In the present study, maternal exposure to BPA increased the acetic acid and propionic acid concentrations in the guts of the offspring.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol Butyrate Esters Inhibit BPA-Induced Liver Damage in Male Offspring Rats by Modulating Antioxidant Capacity and Gut Microbiota

Liao

Chen

Shih

et al. 2021

IJMS

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Resveratrol can affect the physiology or biochemistry of offspring in the maternal–fetal animal model. However, it exhibits low bioavailability in humans and animals. Fifteen-week SD pregnant female rats were orally administered bisphenol A (BPA) and/or resveratrol butyrate ester (RBE), and the male offspring rats (n = 4–8 per group) were evaluated. The results show that RBE treatment (BPA + R30) compared with the BPA group can reduce the damage caused by BPA (p < 0.05). RBE enhanced the expression of selected genes and induced extramedullary hematopoiesis and mononuclear cell infiltration. RBE increased the abundance of S24-7 and Adlercreutzia in the intestines of the male offspring rats, as well as the concentrations of short-chain fatty acids (SCFAs) in the feces. RBE also increased the antioxidant capacity of the liver by inducing Nrf2, promoting the expression of HO-1, SOD, and CAT. It also increased the concentration of intestinal SCFAs, enhancing the barrier formed by intestinal cells, thereby preventing BPA-induced metabolic disruption in the male offspring rats, and reduced liver inflammation. This study identified a potential mechanism underlying the protective effects of RBE against the liver damage caused by BPA exposure during the peri-pregnancy period, and the influence of the gut microbiota on the gut–liver axis in the offspring.

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Section: Discussionmentioning

confidence: 99%

Resveratrol Butyrate Esters Inhibit BPA-Induced Liver Damage in Male Offspring Rats by Modulating Antioxidant Capacity and Gut Microbiota

Liao

Chen

Shih

et al. 2021

IJMS

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“…In another study, interestingly, butyrate concentrations were decreased significantly in mice treated with FMT from STC donors and, after supplementation with butyrate, some constipation-related symptoms in mice were reversed [ 18 ]. Wang et al reported that acetic acid and butyric acid could relieve constipation through different ways [ 60 ]. Actually, the opposite results over the effects of SCFAs on colonic motility have been existing.…”

Section: Possible Roles Of Microbial Metabolites In Fcmentioning

confidence: 99%

Roles of Gut Microbiota and Metabolites in Pathogenesis of Functional Constipation

Wang

Yao

2021

Evidence-Based Complementary and Alternative Medicine

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Functional constipation (FC), a condition characterized by heterogeneous symptoms (infrequent bowel movements, hard stools, excessive straining, or a sense of incomplete evacuation), is prevalent over the world. It is a multifactorial disorder and can be categorized into four subgroups according to different pathological mechanisms: normal transit constipation (NTC), slow transit constipation (STC), defecatory disorders (DD), and mixed type. Recently, growing evidence from human and animals has pointed that there was a strong association between gut microbiota and FC based on the brain-gut-microbiome axis. Studies have reported that the main characteristics of gut microbiota in FC patients were the relative decrease of beneficial bacteria such as Lactobacillus and Bifidobacterium, the relative increase of potential pathogens, and the reduced species richness. Gut microbiota can modulate gut functions through the metabolites of bacterial fermentation, among which short-chain fatty acids (SCFAs), secondary bile salts (BAs), and methane occupied more important positions and could trigger the release of gut hormones from enteroendocrine cells (EECs), such as 5-hydroxytryptamine (5-HT), peptide YY (PYY), and glucagon-like peptide-1 (GLP-1). Subsequently, these gut hormones can influence gut sensation, secretion, and motility, primarily through activating specific receptors distributed on smooth muscle cells, enteric neurons, and epithelial cells. However, research findings were inconsistent and even conflicting, which may be partially due to various confounding factors. Future studies should take the associated confounders into consideration and adopt multiomics research strategies to obtain more complete conclusions and to provide reliable theoretical support for exploring new therapeutic targets.

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“…‘ Erysipelotrichaceae noname ’ is an unidentified genus annotated by MetaPhlAn2 32 below the family Erysipelotrichaceae mentioned above. Prevotella is one of the bacteria producing acetate while acetic acid participating in cholesterol synthesis 39 , 40 . The abundance of these categories were higher in the H. pylori infected groups.…”

Section: Resultsmentioning

confidence: 99%

Glycosaminoglycan biosynthesis pathway in host genome is associated with Helicobacter pylori infection

Wang

et al. 2021

Sci Rep

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Helicobacter pylori is a causative pathogen of many gastric and extra-gastric diseases. It has infected about half of the global population. There were no genome-wide association studies (GWAS) for H. pylori infection conducted in Chinese population, who carried different and relatively homogenous strain of H. pylori. In this work, we performed SNP (single nucleotide polymorphism)-based, gene-based and pathway-based genome-wide association analyses to investigate the genetic basis of host susceptibility to H. pylori infection in 480 Chinese individuals. We also profiled the composition and function of the gut microbiota between H. pylori infection cases and controls. We found several genes and pathways associated with H. pylori infection (P < 0.05), replicated one previously reported SNP rs10004195 in TLR1 gene region (P = 0.02). We also found that glycosaminoglycan biosynthesis related pathway was associated with both onset and progression of H. pylori infection. In the gut microbiome association study, we identified 2 species, 3 genera and several pathways had differential abundance between H. pylori infected cases and controls. This paper is the first GWAS for H. pylori infection in Chinese population, and we combined the genetic and microbial data to comprehensively discuss the basis of host susceptibility to H. pylori infection.

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Acetic acid and butyric acid released in large intestine play different roles in the alleviation of constipation

Cited by 69 publications

References 32 publications

Resveratrol Butyrate Esters Inhibit BPA-Induced Liver Damage in Male Offspring Rats by Modulating Antioxidant Capacity and Gut Microbiota

Resveratrol Butyrate Esters Inhibit BPA-Induced Liver Damage in Male Offspring Rats by Modulating Antioxidant Capacity and Gut Microbiota

Roles of Gut Microbiota and Metabolites in Pathogenesis of Functional Constipation

Glycosaminoglycan biosynthesis pathway in host genome is associated with Helicobacter pylori infection

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