Summary: Blood flow velocities in both middle cerebral arteries and regional cerebral blood flow in their perfu sion territories were measured simultaneously in 36 healthy subjects. In 20 subjects, the measurements were first performed under basal conditions and then repeated 15-20 min after an intravenous injection of 1 g of acet azolamide. Reproducibility of simultaneous blood flow and velocity measurements was tested by examining 16 subjects on two occasions under basal conditions with an interval of 20 min. Relatively good reproducibility was found for repeated measurements of velocity and blood flow, being best when side-to-side asymmetry was as sessed. The increase in blood flow velocities after acet azolamide was symmetrical (right side, 34.2%; and left side, 35.5%), and the velocity increase was significantly correlated with basal values. The increase in cerebralThe effect of severe carotid occlusive disease on cerebral perfusion depends on the potential collat eral circulation and the ability of the cerebral arte rioles to dilate if there is a fall in perfusion pressure. When the capacity for compensatory vasodilation is overwhelmed and regional cerebral blood flow (rCBF) begins to fall, extraction of oxygen from the blood increases. This sequence of haemodynamic