Acetate Upregulates GPR43 Expression and Function via PI3K-AKT-SP1 Signaling in Mammary Epithelial Cells during Milk Fat Synthesis
Yang Yang,
Chuanping Liu,
Caiyan Zhang
et al.
Abstract:This study investigated the mechanism
underlying acetate-induced
orphan G-protein-coupled receptor 43 (GPR43) expression and milk fat
production. The mammary epithelial cells of dairy cows were treated
with acetate, and the effects of GPR43 on acetate uptake and the expression
of lipogenesis-related genes were determined by gas chromatography
and quantitative polymerase chain reaction (qPCR), respectively. RNAi,
inhibitor treatment, and luciferase assay were used to determine the
effect of phosphoinositide 3-k… Show more
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