Acetamiprid, Insecticide-Induced Oxidative Damage on Reproductive Parameters Male Rats

Ibrahim, Hayam M.; El-Banna, Sabah G; Rafea, Ahmed Abd El

doi:10.5455/ajvs.78757

Cited by 5 publications

(4 citation statements)

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“…The testes of animals given AC or AZ show considerable degeneration of spermatogenic cells. Many researchers (Cao et al 2019 ; Arıcan et al 2020 ; Ibrahim et al 2020 ) have recorded that AC or AZ affects the testicular histological structure, as well as spermatogenesis degeneration and sperm reduction. Also, Kong et al’s ( 2017 ) study corresponds with the current data.…”

Section: Discussionmentioning

confidence: 99%

“…In Leydig cells, AC was also discovered to reduce the production of adenosine triphosphate (ATP) and cyclic adenosine monophosphate (cAMP) (Ibrahim et al 2020 ). Because A signaling routes are the major signaling mechanisms of steroidogenesis, ROS generated by AC can block the signal pathway, resulting in decreased testosterone production.…”

Section: Introductionmentioning

confidence: 99%

“…Because A signaling routes are the major signaling mechanisms of steroidogenesis, ROS generated by AC can block the signal pathway, resulting in decreased testosterone production. It reduced the activities of CAT, glutathione peroxidase (GP), and superoxide dismutase (SOD) in mice testes, resulting in excessively high ROS levels (Ibrahim et al 2020 ).…”

Section: Introductionmentioning

confidence: 99%

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Mechanisms and histopathological impacts of acetamiprid and azoxystrobin in male rats

El-Hak

Al-Eisa

Ryad

et al. 2022

Environ Sci Pollut Res

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Acetamiprid (neonicotinoid insecticide) and azoxystrobin (fungicide) are widespread pesticides used for pest management, but they have the potential for toxicity to mammals. The goal of this study was to look for oxidative stress, metabolic alterations, and reproductive problems in male rats’ serum after 2 months of exposure to sub-lethal dosages of acetamiprid and azoxystrobin. Seven classes of male rats were formed: control, 3 groups of acetamiprid (1/10, 1/20, 1/40 LD50), and 3 groups of azoxystrobin (1/10, 1/20, 1/40 LD50) and were orally daily treated (n = 8/group). Our findings revealed that acetamiprid and azoxystrobin disrupted oxidative and metabolic processes in the examined rats throughout 30 and 60 days of testing. The levels of nitric oxide increased significantly, while catalase, a superoxide dismutase enzyme, and glutathione reductase activity were reduced. Serum levels of sex hormones, calcium, and total protein have all dropped substantially in rats. In comparison to the control group, the testis and liver structure, as well as spermatozoa parameters, had distinct histological characteristics. In conclusion, acetamiprid and azoxystrobin exhibit dose- and time-dependent effects on oxidative parameters that cause testis damage.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mechanisms and histopathological impacts of acetamiprid and azoxystrobin in male rats

El-Hak

Al-Eisa

Ryad

et al. 2022

Environ Sci Pollut Res

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show abstract

“…The results showed that plasma testosterone levels and sperm count both decreased in a dose-dependent manner. Additionally, it was proven that ACE inhibited the synthesis of adenosine triphosphate (ATP) and cyclic adenosine monophosphate (cAMP) in Leydig cells [ 118 ]. The application of ACE may cause increasing concentrations of reactive oxygen species (ROS) in the testes, decreasing the overall weight of testosterone-responsive organs, the concentration of serum testosterone, and sperm quality [ 96 ].…”

Section: Characterization Of Acetamipridmentioning

confidence: 99%

Screening of Toxic Effects of Neonicotinoid Insecticides with a Focus on Acetamiprid: A Review

Zuščíková,

Bažány,

Greifová

et al. 2023

Toxics

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Recently, neonicotinoids have become the fastest-growing class of insecticides in conventional crop protection, with extensive usage against a wide range of sucking and chewing pests. Neonicotinoids are widely used due to their high toxicity to invertebrates, simplicity, flexibility with which they may be applied, and lengthy persistence, and their systemic nature ensures that they spread to all sections of the target crop. However, these properties raise the risk of environmental contaminations and potential toxicity to non-target organisms. Acetamiprid is a new generation insecticide, which is a safer alternative for controlling insect pests because of its low toxicity to honeybees. Acetamiprid is intended to target nicotinic acetylcholine receptors in insects, but its widespread usage has resulted in negative impacts on non-target animals such as mammals. This review summarizes in vivo and in vitro animal studies that investigated the toxicity of specific neonicotinoids. With summarized data, it can be presumed that certain concentrations of neonicotinoids in the reproductive system cause oxidative stress in the testis; spermatogenesis disruption; spermatozoa degradation; interruptions to endocrine function and Sertoli and Leydig cell function. In the female reproductive system, acetamiprid evokes pathomorphological alterations in follicles, along with metabolic changes in the ovaries.

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Toxicity of the acetamiprid insecticide for mammals: a review

et al. 2022

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Acetamiprid, Insecticide-Induced Oxidative Damage on Reproductive Parameters Male Rats

Cited by 5 publications

References 0 publications

Mechanisms and histopathological impacts of acetamiprid and azoxystrobin in male rats

Mechanisms and histopathological impacts of acetamiprid and azoxystrobin in male rats

Screening of Toxic Effects of Neonicotinoid Insecticides with a Focus on Acetamiprid: A Review

Toxicity of the acetamiprid insecticide for mammals: a review

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