Acetaminophen (paracetamol)

In vitro and in situ evaluation of herb–drug interactions during intestinal metabolism and absorption of Baicalein

“…1). APAP is widely used over-the-counter antipyretic and analgesic agent with a phenolic structure (Tanaka, 2005). It had been demonstrated to undergo intestinal phase II metabolism in vitro (Grafström et al, 1979) and in situ (Pang et al, 1986;Goon and Klaassen, 1990).…”