Acetaminophen

Fairbrother, J.E.

doi:10.1016/s0099-5428(08)60064-7

Cited by 36 publications

(15 citation statements)

References 198 publications

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“…Available data on the fusion of the two forms are compiled in Table 2 and indicate that: (i) the melting temperaures of the monoclinic (Form I) and the orthorhombic (Form II) phases of paracetamol range within 440–445 K21–24,34,37–57 and 427–433 K,21,33,34,37,40,51–56 respectively, (ii) the melting enthalpies range within +26 and +34.1 kJ · mol −1 for Form I at T fus (I),22–24,34,40–42,46–49,57 and within +26.4 and +33.5 kJ · mol −1 for Form II at T fus (II) 34,51–56…”

Section: Structural and Thermodynamic Data From The Literaturementioning

confidence: 99%

Polymorphism of paracetamol: Relative stabilities of the monoclinic and orthorhombic phases inferred from topological pressure‐temperature and temperature‐volume phase diagrams

Espeau

Céolin

Tamarit

et al. 2005

Journal of Pharmaceutical Sciences

119

107

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Section: Structural and Thermodynamic Data From The Literaturementioning

confidence: 99%

Polymorphism of paracetamol: Relative stabilities of the monoclinic and orthorhombic phases inferred from topological pressure‐temperature and temperature‐volume phase diagrams

Espeau

Céolin

Tamarit

et al. 2005

Journal of Pharmaceutical Sciences

119

107

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“…Spectra of samples with highest (15%) added polymer were recorded so as to ensure that any interactions would be revealed. From Figure 3 a, it can be seen that for neat PCT, characteristic peaks appear at 1650 cm −1 (C=O stretching band), at 1506 and 1562 cm −1 (C-N amide stretching) and at 1614 and 1440 cm −1 (C-C aromatic stretching) [ 24 , 30 ]. These also appear in the spectra of PCT-hpc15 and PRP-hpmc15 in Figure 3 a without sh0ift, indicating lack of drug–polymer interaction.…”

Section: Resultsmentioning

confidence: 99%

Co-Spray Drying of Paracetamol and Propyphenazone with Polymeric Binders for Enabling Compaction and Stability Improvement in a Combination Tablet

et al. 2021

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Paracetamol (PCT) and propyphenazone (PRP) are analgesic drugs that are often combined in a single dosage form for enhanced pharmacological action. In this work, PCT and PRP were co-spray dried separately with hydroxypropyl methylcellulose (HPMC) and hydroxypropyl cellulose (HPC) using drug suspensions in polymer solutions as feed liquids. It was thought that because of polymer adherence to the surface of drug particles, the risk of PCT–PRP contact and interaction could be reduced. Such interaction may be caused by localized temperature gradients due to frictional forces during tableting, or during storage under harsh conditions. A worst-case scenario would be eutectic formation due to variations in powder mixture homogeneity since eutectic and therapeutic mass PCT/PRP ratios are close (65:35 and 60:40, respectively) and eutectic temperature is low (~56 °C). Uniform particle size, round shape, compaction improvement and faster release of the analgesics were important additional benefits of co-spray drying. Experimental design was first applied for each drug to optimize the polymer concentration on the yield of spray drying and melting point separation (Δmp) of heated binary mixtures of co-spray dried PCT/neat PRP, and vice versa, with the two drugs always included at their therapeutic 60:40 ratio. Optimal combinations with largest Δmp and production yield were: co-spray dried PCT (15% HPC) with neat PRP and co-spray dried PRP (10% HPMC) with neat PCT. Compression studies of these combinations showed tableting improvement due to the polymers, as reflected in greater work of compaction and solid fraction, greater fracture toughness and tablet strength, easier tablet detachment from the punch surface and ejectability. Faster release of both drugs was obtained from the tablet of co-spray dried PCT (15% HPC) with neat PRP. A one-month stability test (75% RH/40 °C) showed moisture-induced alteration tablet strength.

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“…For control assay purposes, a colorimetric ion-pairing assay has been adapted in this laboratory for determining I1 as described for codeine (17). A titration of an extract is reported for hydrocodone bitartrate tablets (16).…”

Section: Discussionmentioning

confidence: 99%

Simultaneous Assay of Hydrocodone Bitartrate and Acetaminophen in a Tablet Formulation

Wallo

D’adamo

1982

Journal of Pharmaceutical Sciences

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Acetaminophen

Cited by 36 publications

References 198 publications

Polymorphism of paracetamol: Relative stabilities of the monoclinic and orthorhombic phases inferred from topological pressure‐temperature and temperature‐volume phase diagrams

Polymorphism of paracetamol: Relative stabilities of the monoclinic and orthorhombic phases inferred from topological pressure‐temperature and temperature‐volume phase diagrams

Co-Spray Drying of Paracetamol and Propyphenazone with Polymeric Binders for Enabling Compaction and Stability Improvement in a Combination Tablet

Simultaneous Assay of Hydrocodone Bitartrate and Acetaminophen in a Tablet Formulation

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