Acetaminophen influences social and economic trust

Roberts, Ian D.; Krajbich, Ian; Way, Baldwin M.

doi:10.1038/s41598-019-40093-9

Cited by 12 publications

(6 citation statements)

References 40 publications

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“…headache; cold symptoms) also could fundamentally change the drug’s psychological effects. Thus, as we have demonstrated ( Roberts et al. , 2019 ), acetaminophen’s psychological and behavioral effects are likely state- and context-dependent, defying the simple categorization of a newspaper headline.…”

mentioning

confidence: 75%

The need for studies of acetaminophen’s impact on risk-taking in daily life; reply to Ross and Holstege (2021)

Way

Peters

Keaveney

2021

Social Cognitive and Affective Neuroscience

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mentioning

confidence: 75%

The need for studies of acetaminophen’s impact on risk-taking in daily life; reply to Ross and Holstege (2021)

Way

Peters

Keaveney

2021

Social Cognitive and Affective Neuroscience

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“…19. APAP use in adults temporarily blunts social trust [53] and awareness [54], emotional responses to external stimuli [55], and the ability to identify errors [56], indicating that the drug targets regions of the brain affected in patients with ASD.…”

Section: Summary Of Evidencementioning

confidence: 99%

The Dangers of Acetaminophen for Neurodevelopment Outweigh Scant Evidence for Long-Term Benefits

Parker,

Anderson,

Jones

et al. 2023

Children

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Based on available data that include approximately 20 lines of evidence from studies in laboratory animal models, observations in humans, correlations in time, and pharmacological/toxicological considerations, it has been concluded without reasonable doubt and with no evidence to the contrary that exposure of susceptible babies and children to acetaminophen (paracetamol) induces many, if not most, cases of autism spectrum disorder (ASD). However, the relative number of cases of ASD that might be induced by acetaminophen has not yet been estimated. Here, we examine a variety of evidence, including the acetaminophen-induced reduction of social awareness in adults, the prevalence of ASD through time, and crude estimates of the relative number of ASD cases induced by acetaminophen during various periods of neurodevelopment. We conclude that the very early postpartum period poses the greatest risk for acetaminophen-induced ASD, and that nearly ubiquitous use of acetaminophen during early development could conceivably be responsible for the induction in the vast majority, perhaps 90% or more, of all cases of ASD. Despite over a decade of accumulating evidence that acetaminophen is harmful for neurodevelopment, numerous studies demonstrate that acetaminophen is frequently administered to children in excess of currently approved amounts and under conditions in which it provides no benefit. Further, studies have failed to demonstrate long-term benefits of acetaminophen for the pediatric population, leaving no valid rationale for continued use of the drug in that population given its risks to neurodevelopment.

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“…McCarthy [36], in particular, show that the male brain is more sensitive to the drug than the female brain, potentially explaining the preponderance of males with ASD even in populations with no practice of circumcision. Further, acetaminophen is known to impair social functioning in human adults [55][56][57],…”

Section: Postnatal Exposure To Acetaminophen: Overwhelming Circumstan...mentioning

confidence: 99%

“…14. Acetaminophen use in adults temporarily blunts social trust [56] and awareness [55], emotional responses to external stimuli [57], and the ability to identify errors [75], indicating that the drug targets regions of the brain affected in patients with ASD.…”

Section: Not Valid: a Classic Consensus Biasmentioning

confidence: 99%

Available Evidence Indicates That Pediatric Use of Acetaminophen Adversely Affects Neurodevelopment in Susceptible Babies and Children

Parker¹,

Patel²,

Jones³

et al. 2022

Preprint

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Acetaminophen use during pregnancy and early childhood was accepted in the 1970s, but is now a subject of considerable concern. Careful analysis shows that initial acceptance of the drug was based on false assumptions and ignorance of the impact of the drug on brain development. Fourteen studies now indicate that prenatal exposure to acetaminophen is associated with neurodevelopmental problems. Based on corrections for confounding factors applied to the analyses of available data, it can be concluded that prenatal exposure to acetaminophen causes statistically significant risks of one subtype of autism spectrum disorder (ASD), developmental delays, and attention deficit hyperactivity disorder. In contrast, data regarding postnatal exposure to acetaminophen are limited, and several factors impede a classic multivariate analysis of data to resolve the issue. However, circumstantial evidence regarding postnatal exposure to the drug is abundant, and it can be concluded beyond a reasonable doubt that postnatal exposure to acetaminophen in susceptible children is responsible for many if not most cases of ASD. Circumstantial evidence includes at least three otherwise unexplained temporal relationships, data from laboratory animal studies, several miscellaneous and otherwise unexplained correlations, and the lack of alternative suspects that fit the evidence-derived profile.

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Acetaminophen influences social and economic trust

Cited by 12 publications

References 40 publications

The need for studies of acetaminophen’s impact on risk-taking in daily life; reply to Ross and Holstege (2021)

The need for studies of acetaminophen’s impact on risk-taking in daily life; reply to Ross and Holstege (2021)

The Dangers of Acetaminophen for Neurodevelopment Outweigh Scant Evidence for Long-Term Benefits

Available Evidence Indicates That Pediatric Use of Acetaminophen Adversely Affects Neurodevelopment in Susceptible Babies and Children

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