Acetaminophen-induced nephrotoxicity in rats: Protective role of<i>Cardiospermum halicacabum</i>

Parameshappa, B.; Basha, S.A.; Sen, Saikat; Chakraborty, Raja; Kumar, Gokul Vinod; Sagar, G. Vidya; Sowmya, L.; Raju, K. Kantha; Kumar, Pawan; Lakshmi, Anusha

doi:10.3109/13880209.2011.596843

Cited by 22 publications

(15 citation statements)

References 24 publications

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“…Our results in this study were agree with a previous results suggested all that alterations in sera levels when analysis were taken as an evidence of APAP causing nephreotoxicity in rats models [23,24]. Furthermore, Vigila and Baskaran [25], noticed that, in rats' nephrotoxicity and renal diseases, blood urea and creatinine increased, while proteins and albumin were significantly reduced.…”

Section: Discussionsupporting

confidence: 83%

Assessment of ameliorative effects of aqueous extracts of Moringa oleifera on acetaminophen -induced nephrotoxicity in rats

Tayib¹,

Badwi²

2016

IOSR

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Abstract:-The ameliorative effects of Moringa oleifera L. (M. oleifera) is well known to modulate and enhance several immune parameters. The present study investigates the efficacy of the aqueous extract leaves of the M. oleifera on prevention of acetaminophen (APAP) induced acute renal injury in Wistar rats. Thirty albino rats were arranged randomly into 5 groups of 5 rats. Group 2 served as intoxicated group and received APAP (200 mg/kg). Group 3, 4 and 5 received APAP (200 mg/kg) + M. oleifera at doses 250, 500 and 1000 mg/kg, respectively. While first group was served as control rats group. All treatment was given orally to animals for 14 days. Clinical signs were observed regularly and rats were sacrificed and bloods and tissue samples were collected for biochemical and histological analysis. Biochemical results showed that M. oleifera protected the toxic remarks caused by APAP when decrease the elevated levels of serum creatinine, blood urea, cholesterol and lipids, while increases the plasma levels of total protein and albumin. Also, the nephroprotective effects of extracts was strongly correlated with decreased damage of the renal cellular damage, as evidenced by histological findings when compared to the group treated with APAP. Our findings provide evidence to demonstrate that aqueous extract of M. oleifera has a potent nephroprotective effect on APAP-induced kidney injury in rats. It is proposed that the action of plant is through its antioxidative and its ability to restoration or promoting glutathione (GSH) through decrease in the biotransformation of APAP via cytochrome P-450 pathway.

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Section: Discussionsupporting

confidence: 83%

Assessment of ameliorative effects of aqueous extracts of Moringa oleifera on acetaminophen -induced nephrotoxicity in rats

Tayib¹,

Badwi²

2016

IOSR

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“…This was achieved as previously described [21]. Briefly, the animals were fasted overnight for 14 h and a single oral dose of APAP (750 mg/kg body weight (b.w.))…”

Section: Methodsmentioning

confidence: 99%

Membrane Stabilization and Detoxification of Acetaminophen-Mediated Oxidative Onslaughts in the Kidneys of Wistar Rats by Standardized Fraction ofZea maysL. (Poaceae),Stigma maydis

Sabiu

O’Neill

Ashafa

2016

Evidence-Based Complementary and Alternative Medicine

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This study evaluated membrane stabilization and detoxification potential of ethyl acetate fraction of Zea mays L., Stigma maydis in acetaminophen-induced oxidative onslaughts in the kidneys of Wistar rats. Nephrotoxic rats were orally pre- and posttreated with the fraction and vitamin C for 14 days. Kidney function, antioxidative and histological analyses were thereafter evaluated. The acetaminophen-mediated significant elevations in the serum concentrations of creatinine, urea, uric acid, sodium, potassium, and tissue levels of oxidized glutathione, protein-oxidized products, lipid peroxidized products, and fragmented DNA were dose-dependently assuaged in the fraction-treated animals. The fraction also markedly improved creatinine clearance rate, glutathione, and calcium concentrations as well as activities of superoxide dismutase, catalase, glutathione reductase, and glutathione peroxidase in the nephrotoxic rats. These improvements may be attributed to the antioxidative and membrane stabilization activities of the fraction. The observed effects compared favorably with that of vitamin C and are informative of the fraction's ability to prevent progression of renal pathological conditions and preserve kidney functions as evidently supported by the histological analysis. Although the effects were prominently exhibited in the fraction-pretreated groups, the overall data from the present findings suggest that the fraction could prevent or extenuate acetaminophen-mediated oxidative renal damage via fortification of antioxidant defense mechanisms.

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“…[4567] Apart from this, pharmacological evaluation of C. halicacabum extracts showed that the plant possesses antimalarial,[8] antifilarial,[9] antiparasitic,[10] antipyretic,[11] anti-inflammatory,[12] antianxiety[13] and nephroprotective activity. [14] Furthermore, the plant showed antiulcer activity,[15] antihyperglycemic activity against streptozotocin-induced diabetes in rats and antidiarrheal potential in mice. [7]…”

Section: Introductionmentioning

confidence: 99%

Pharmacognostical evaluation of Cardiospermum halicacabum Linn. leaf and stem

et al. 2013

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Background:Cardiospermum halicacabum Linn (Sapindaceae) is an important medicinal plant in the traditional system of medicine, known as karṇasphoṭa. The root of it is officially included in Ayurvedic Pharmacopoeia for its therapeutic uses such as jvara, kuṣṭha, pāṇḍu, kṣaya and sandhivāta etc. As no detailed analysis of macroscopy, microscopy characters of the plant, except root, have been carried out till date, it was thought worth to carry out the detailed macroscopic and microscopic study of leaves and stem, following standard pharmacognostical procedures.Materials and Methods:Pharmacognostic studies of C. halicacabum were carried out, and in this, the macroscopic, microscopic, physicochemical, fluorescence and phytochemical analyses were done. Physicochemical parameters such as total ash, moisture content, extractive values were determined by World Health Organization guidelines. The microscopic features of leaf and stem components were observed.Results:Macroscopically the leaves are bi-ternate, ovate-lanceolate in shape with dentate margin. Microscopically, leaf shows prominent midrib and thin dorsiventral lamina. The midrib shows the presence of epidermal layers, angular collenchyma, palisade cells and vascular strands comprised of thin walled xylem and thick walled phloem elements. The lamina shows prominent, narrow and cylindrical upper epidermis. The upper epidermal cells are large and contain mucilage, whereas lower epidermis possesses thin, small and elliptical epidermal cells. The mesophyll was differentiated into two zones upper and lower. The upper zones show narrow cylindrical palisade cells and lower zone shows 2-3 layers of loosely arranged spongy parenchyma cells. In the Paradermal section of the lamina we observe anomocytic stomata. The transverse section of stem shows a pentagonal appearance with five short blunt ridges and prominent cuticle. Parenchymatous cells, cortical sclerenchyma, lignified xylem fibers, phloem and pit were also found. In the powder microscopy of whole plant, glandular trichomes, non-glandular trichomes, fragments of lamina, xylem elements, parenchyma cells and fibers are observed. Phytochemical screening reveals that the C. halicacabum extract contains glycosides, carbohydrates, flavonoids, phytosterols, phenolic compounds and saponin.Conclusion:Various pharmacognostic characters observed in this study help in identification, quality, purity and standardization of C. halicacabum.

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Acetaminophen-induced nephrotoxicity in rats: Protective role ofCardiospermum halicacabum

Cited by 22 publications

References 24 publications

Assessment of ameliorative effects of aqueous extracts of Moringa oleifera on acetaminophen -induced nephrotoxicity in rats

Assessment of ameliorative effects of aqueous extracts of Moringa oleifera on acetaminophen -induced nephrotoxicity in rats

Membrane Stabilization and Detoxification of Acetaminophen-Mediated Oxidative Onslaughts in the Kidneys of Wistar Rats by Standardized Fraction ofZea maysL. (Poaceae),Stigma maydis

Pharmacognostical evaluation of Cardiospermum halicacabum Linn. leaf and stem

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