2009
DOI: 10.1080/00498250802512830
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Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes

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Cited by 225 publications
(123 citation statements)
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“…However, whether there is some other antioxidant signals involved in the protection of CGA against AP-induced liver injury has not been identified. Liver CYP2E1, CYP1A2, and CYP3A4 have been reported to be the key metabolic enzymes responsible for metabolizing AP (Laine et al, 2009). In this present study, we observed the protection of CGA against AP-induced hepatotoxicity in vitro and in vivo, and then observed the potential effects of CGA on CYP2E1, CYP1A2, and CYP3A4 enzymatic properties and their expression, and finally observed the involvement of some antioxidant signals in the protection of CGA against AP-induced liver injury.…”
Section: Introductionsupporting
confidence: 65%
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“…However, whether there is some other antioxidant signals involved in the protection of CGA against AP-induced liver injury has not been identified. Liver CYP2E1, CYP1A2, and CYP3A4 have been reported to be the key metabolic enzymes responsible for metabolizing AP (Laine et al, 2009). In this present study, we observed the protection of CGA against AP-induced hepatotoxicity in vitro and in vivo, and then observed the potential effects of CGA on CYP2E1, CYP1A2, and CYP3A4 enzymatic properties and their expression, and finally observed the involvement of some antioxidant signals in the protection of CGA against AP-induced liver injury.…”
Section: Introductionsupporting
confidence: 65%
“…It has been reported that CYP2E1, CYP3A4, and CYP1A2 are the key CYP450 enzymes for the metabolic activation of AP in human liver, and that the metabolic product of AP in the liver will cause serious hepatotoxicity (Raucy et al, 1989;Laine et al, 2009). In addition, AP has been reported to be metabolized into AM404, which acts on transient receptor potential vanilloid 1 (TRPV1), cyclooxygenase (COX), and endogenous cannabinoid system, contributing to antipyretic and analgesic effects of AP (Högestätt et al, 2005).…”
Section: Discussionmentioning
confidence: 99%
“…Acetaminophen is also reported to be a CAII inhibitor [40]. Using human recombinant CYPs, 3A4 was found to be the most efficient in the generation of NAPQI, followed by CYP2E1 [65]. CYP1A1, CYP1A2, CYP2C19, and CYP2D6 had intermediate activity, while CYP2A6, CYP2B6, and CYP2C9 had weak activity.…”
Section: Results: Disproportionate Molecular Targets Identified By Damentioning
confidence: 99%
“…We believe the reason for this is that kale ingestion inflular damage in humans and experimental animals (15,29). Previous reports (4,10,17,20,26) have shown that CYP3A4, CYP1A2, CYP2D6, and CYP2E1 are involved in the metabolism of AA. In addition, it has been reported that ITCs had an inhibitory effect on CYP activity (6,7,12,14,23).…”
Section: Resultsmentioning
confidence: 94%