Acetaminophen

Highly selective and sensitive voltammetric sensor based on modified multiwall carbon nanotube paste electrode for simultaneous determination of ascorbic acid, acetaminophen and tryptophan

“…Acetaminophen, paracetamol or N-acetyl-p-aminophenol [38,39] is a mild, safe, widely used analgesic and antipyretic substitute of aspirin. However, it causes liver necrosis in humans and experimental animals when high doses are administered [40].…”

Biowaiver monographs for immediate release solid oral dosage forms: Acetaminophen (paracetamol)

“…[7][8][9][10][11][12] Orthorhombic acetaminophen is suitable for direct compression tableting and may also be slightly more soluble [13] but has been crystallized only in small quantities and the only commercially available form is monoclinic acetaminophen, the thermodynamically most stable modification. [14] Solubility One part of acetaminophen is soluble in 70 parts of water at room temperature [15], [16] and soluble 1 in 20 parts in boiling water. [4], [15] Other sources report an aqueous solubility of 14.7 mg/mL at 20°C, [17] 14.3 mg/mL at 25°C, [18] and 23.7 mg/mL at 37°C.…”

“…[14] Solubility One part of acetaminophen is soluble in 70 parts of water at room temperature [15], [16] and soluble 1 in 20 parts in boiling water. [4], [15] Other sources report an aqueous solubility of 14.7 mg/mL at 20°C, [17] 14.3 mg/mL at 25°C, [18] and 23.7 mg/mL at 37°C. [17] Partition Coefficient A logP (n-octanol/water) value of 0.2 has been measured.…”

In-Process Crystallization of Acidic Drugs in Acrylic Microparticle Systems: Influence of Physical Factors and Drug–Polymer Interactions

“…In the case of paracetamol, the amorphous drug has a peak at 1656 and 1565 cm −1 (Fig. 8), corresponding to CO stretching of the amide group and aromatic vibration, respectively 23. The shouldering at 1660 cm −1 and negative shift to a lower wave number in paracetamol‐loaded microparticles can be assigned to hydrogen bonding.…”