Acetal containing polymers as pH-responsive nano-drug delivery systems

Acetalated dextran based nano- and microparticles: synthesis, fabrication, and therapeutic applications

“…8 The hydrophobicity and solubility in organic solvents makes Ac-DEX favourable for drug encapsulation by both precipitation and emulsion techniques, and the acid-triggered degradation makes it possible to release the drug in specific acidified conditions, such as endosomal compartments, tumour microenvironment and inflamed area. 9 As a result of its relatively simple preparation, fabrication and controllable degradation, the past decade has witnessed a growing interest in Ac-DEX-based drug delivery systems with a considerable amount of literature published every year. For example, there is a review about Ac-DEX by Bachelder et al in 2016, 10 focusing on the original development of this polymer and its applications especially in vaccine delivery.…”

Targeted delivery by pH-responsive mPEG-S-PBLG micelles significantly enhances the anti-tumor efficacy of doxorubicin with reduced cardiotoxicity

“…Since the pH value of tumor sites (6.5–7.0) is lower than that of normal tissues (∼7.4), pH-responsive polymeric micelles are expected to increase drug accumulation in tumor sites and reduce drug leakage to normal organs and tissues (Gannimani et al., 2020 ). In this study, the pH-sensitive copolymers (mPEG-S-PBLG) were synthesized through one-step ROP of l -BLG NCA with mPEG-S-NH 2 as macroinitiator.…”

Macromolecular Nanotherapeutics and Antibiotic Adjuvants to Tackle Bacterial and Fungal Infections

“…This type of stimuli responsive smart drug delivery system easily improves the effectiveness of the antibiotic, increased the pharmacokinetic value, reduce the tendency of resistant growth against antibiotic, and most importantly improve the biocompatibility of the drugs toward mammalian tissue and cells. [ 173–185 ] In addition to the infectious disease, other diseases like cancer, etc., also have similar microenvironments like bacterial infections including acidic pH, anaerobic condition, and prolonged inflammation, which can lead to the design of smart targeted and responsive drug delivery systems same as bacterial infection case. Although, there are obvious differences in the physical characteristics of the diseases.…”