Acerola fruit by-product alleviates lipid, glucose, and inflammatory changes in the enterohepatic axis of rats fed a high-fat diet

Batista, Kamila Sabino; Soares, Naís Lira; Dorand, Victor Augusto Mathias; Alves, Adriano Francisco; Lima, Marcos dos Santos; Pereira, Ramon de Alencar; Souza, Evandro Leite de; Magnani, Marciane; Persuhn, Darlene Camati; Aquino, Jailane de Souza

doi:10.1016/j.foodchem.2022.134322

Cited by 8 publications

(3 citation statements)

References 50 publications

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“…Jia et al [ 19 ] considered the density of lipoprotein was related to the transport of cholesterol as well as HDL-C and VLDL-C has been considered to have a protective effect for liver lipid metabolism, while LDL-C was harmful to liver. Batista et al [ 20 ] considered high level of VLDL could promote lipolysis. Importantly, our previous study suggested that Lp.…”

Section: Discussionmentioning

confidence: 99%

Lactiplantibacillus plantarum FRT4 attenuates high-energy low-protein diet-induced fatty liver hemorrhage syndrome in laying hens through regulating gut-liver axis

Li,

Cai,

Liu

et al. 2024

J Animal Sci Biotechnol

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Background Fatty liver hemorrhage syndrome (FLHS) becomes one of the most major factors resulting in the laying hen death for caged egg production. This study aimed to investigate the therapeutic effects of Lactiplantibacillus plantarum (Lp. plantarum) FRT4 on FLHS model in laying hen with a focus on liver lipid metabolism, and gut microbiota. Results The FLHS model of laying hens was established by feeding a high-energy low-protein (HELP) diet, and the treatment groups were fed a HELP diet supplemented with differential proportions of Lp. plantarum FRT4. The results indicated that Lp. plantarum FRT4 increased laying rate, and reduced the liver lipid accumulation by regulating lipid metabolism (lipid synthesis and transport) and improving the gut microbiota composition. Moreover, Lp. plantarum FRT4 regulated the liver glycerophospholipid metabolism. Meanwhile, “gut-liver” axis analysis showed that there was a correlation between gut microbiota and lipid metabolites. Conclusions The results indicated that Lp. plantarum FRT4 improved the laying performance and alleviated FLHS in HELP diet-induced laying hens through regulating “gut-liver” axis. Our findings reveal that glycerophospholipid metabolism could be the underlying mechanism for the anti-FLHS effect of Lp. plantarum FRT4 and for future use of Lp. plantarum FRT4 as an excellent additive for the prevention and mitigation of FLHS in laying hens.

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Section: Discussionmentioning

confidence: 99%

Lactiplantibacillus plantarum FRT4 attenuates high-energy low-protein diet-induced fatty liver hemorrhage syndrome in laying hens through regulating gut-liver axis

Li,

Cai,

Liu

et al. 2024

J Animal Sci Biotechnol

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“…Several studies have highlighted that an HFD has a negative impact on human health based on its association with obesity, type 2 diabetes, hypertension, IBD, leaky gut, and cardiovascular diseases [ 25 , 27 - 29 ]. Previous studies have shown that consistent dietary fat consumption can lead to metabolic disorders, including insulin resistance and elevated levels of triglycerides (TGs), total cholesterol (TC), low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and serum glucose [ 30 ]. In rodent studies, feeding with a 60% fat diet may induce inflammation in adipose tissues, which is a significant component of metabolic syndrome [ 31 ].…”

Section: Hfdmentioning

confidence: 99%

Diet-Induced Gut Dysbiosis and Leaky Gut Syndrome

Chae,

Lee,

Kim

et al. 2024

J. Microbiol. Biotechnol.

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Chronic gut inflammation promotes the development of metabolic diseases such as obesity. There is growing evidence which suggests that dysbiosis in gut microbiota and metabolites disrupt the integrity of the intestinal barrier and significantly impact the level of inflammation in various tissues, including the liver and adipose tissues. Moreover, dietary sources are connected to the development of leaky gut syndrome through their interaction with the gut microbiota. This review examines the effects of these factors on intestinal microorganisms and the communication pathways between the gut-liver and gut-brain axis. The consumption of diets rich in fats and carbohydrates has been found to weaken the adherence of tight junction proteins in the gastrointestinal tract. Consequently, this allows endotoxins, such as lipopolysaccharides produced by detrimental bacteria, to permeate through portal veins, leading to metabolic endotoxemia and alterations in the gut microbiome composition with reduced production of metabolites, such as short-chain fatty acids. However, the precise correlation between gut microbiota and alternative sweeteners remains uncertain, necessitating further investigation. This study highlights the significance of exploring the impact of diet on gut microbiota and the underlying mechanisms in the gut-liver and gut-brain axis. Nevertheless, limited research on the gut-liver axis poses challenges in comprehending the intricate connections between diet and the gut-brain axis. This underscores the need for comprehensive studies to elucidate the intricate gut-brain mechanisms underlying intestinal health and microbiota.

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“…Results showed reduced weight gain, adiposity and improved insulin sensitivity, as well as increased HDL-cholesterol levels and prevented hepatic steatosis, proving to be an adequate strategy to prevent or control obesity. Acerola (Malpighia emarginata) (peel, residual pulp, seeds) waste extracts, orogastric administrated by gavage, reduced the weight of rats fed with a highfat diet, decreased the serum TG, TC, LDL levels and increased HDL level [9]. Also, administration of acerola extracts increased the cellular glucose uptake and showed a good tolerance to insulin action on glucose level.…”

Section: Obesitymentioning

confidence: 99%

Short Review on Bioactive Compounds Recovered From Vegetal Waste as a New Tool in Diabetes, Obesity and Dyslipidaemia Prevention and Treatment

SPÎNU¹

2022

FARMACIA

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Following the processing of vegetal material, impressive amounts of vegetal waste are produced at global level. Currently, vegetal waste management from industries that use vegetal material are of interest at international level, both for economic and environmental reasons. Metabolic diseases are clinical manifestations characterized by comorbidities as obesity, arterial hypertension, dyslipidaemia and diabetes, which induce low-grade inflammation and oxidative stress. In recent years, for the prevention and treatment of metabolic diseases, the development of new therapeutic strategies, with fewer side effects, based on bioactive compounds resulting mainly from plant waste, has been attempted. These biocompounds have various beneficial effects on lipid and glucose metabolism, blood pressure, oxidative stress and body weight. The aim of this short review is to highlight the bioactive compounds recovered from vegetal waste as a new tool in diabetes, obesity and dyslipidaemia prevention and treatment. RezumatÎn urma prelucrării materialului vegetal, la nivel global se produc cantități impresionante de deșeuri vegetale. În prezent, gestionarea deșeurilor vegetale din industriile care utilizează material vegetal prezintă interes la nivel internațional, atât din motive economice, cât și de mediu. Bolile metabolice sunt manifestări clinice caracterizate prin comorbidități precum obezitatea, hipertensiunea arterială, dislipidemia și diabetul, care induc inflamație de grad scăzut și stres oxidativ. In ultimii ani, pentru prevenția și tratamentul bolilor metabolice s-a încercat dezvoltarea de noi strategii terapeutice, cu mai puține efecte secundare, bazate pe compuși bioactivi rezultați în principal din deșeuri vegetale. Aceștia au diverse efecte benefice asupra metabolismului lipidelor și glucozei, tensiunii arteriale, stresului oxidativ și greutății corporale. Scopul acestei scurte recenzii este de a evidenția compușii bioactivi recuperați din deșeurile vegetale ca un nou instrument în prevenirea și tratamentul diabetului, obezității și dislipidemiei.

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Acerola fruit by-product alleviates lipid, glucose, and inflammatory changes in the enterohepatic axis of rats fed a high-fat diet

Cited by 8 publications

References 50 publications

Lactiplantibacillus plantarum FRT4 attenuates high-energy low-protein diet-induced fatty liver hemorrhage syndrome in laying hens through regulating gut-liver axis

Lactiplantibacillus plantarum FRT4 attenuates high-energy low-protein diet-induced fatty liver hemorrhage syndrome in laying hens through regulating gut-liver axis

Diet-Induced Gut Dysbiosis and Leaky Gut Syndrome

Short Review on Bioactive Compounds Recovered From Vegetal Waste as a New Tool in Diabetes, Obesity and Dyslipidaemia Prevention and Treatment

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