Acenocoumarol-Induced Henoch-Schönlein Purpura

Borrás-Blasco, Joaquı́n; Girona, Eva; Ruíz, A Navarro; Matarredona, Jaime; Giménez, María Encarnación; Gutiérrez, Ana; Enríquez, Ricardo; Martinez, Antonio

doi:10.1345/aph.1d270

Cited by 19 publications

(12 citation statements)

References 19 publications

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“…During the PubMed search, we found that acenocoumarol, an oral anticoagulant of the coumarin family, has also been associated with cases of vasculitis (5,7,8,11). Thus, we added "acenocoumarol" as a keyword in the literature search as well.…”

Section: Review Of the Literaturementioning

confidence: 99%

“…Ten reports were identified in the English-language literature from the years 1980 to 2011 (3)(4)(5)(6)(7)(8)(9)(10)(11)(12). From the reports we collected the following data: patient age at onset, cutaneous manifestations, latency (from initiation of treatment to onset of skin manifestations), treatment strategies for vasculitis, concomitant medications, and outcome.…”

Section: Review Of the Literaturementioning

confidence: 99%

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Warfarin-induced Leukocytoclastic Vasculitis: A Case Report and Review of Literature

2012

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Warfarin is widely prescribed for patients with atrial fibrillation. In addition to unexpected bleeding, allergic skin reaction is one of its uncommon adverse effects. We herein report an 89-year-old man who, after taking warfarin for 4 years, suffered extensive skin eruptions. The skin biopsy disclosed leukocytoclastic vasculitis. The causal relationship between skin lesions and warfarin was confirmed after re-challenge of warfarin. A literature review revealed only 13 such cases reported from 1980 to 2011. Clinicians should be aware of this potential adverse effect of warfarin.

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Section: Review Of the Literaturementioning

confidence: 99%

Section: Review Of the Literaturementioning

confidence: 99%

Warfarin-induced Leukocytoclastic Vasculitis: A Case Report and Review of Literature

2012

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“…The association between drugs and HSP has been reported in many studies, though the role of drug in the pathogenesis of HSP is uncertain. Among the drugs reported to be related to the development of HSP, there have been antibiotics [10], anti-emetics [11], analgesia [12], anticoagulants [13], anticonvulsants [14], TNF-α inhibitors [15] for autoimmune diseases, anti-hypertensive [16], anti-neoplastic [17] and anti-arrhythmic agents [18], as well as antidepressants [19].…”

Section: Discussionmentioning

confidence: 99%

Henoch-Scholein Purpura Related to Fluoxetine Medication in a Child

Hung¹,

Chuo²,

Chen³

et al. 2018

Neuropsychiatry

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Background: Fluoxetine, one kind of selective serotonin reuptake inhibitors (SSRI), has rarely been reported to be related to vasculitis in adults. Methods: Herein we present a boy who developed Henoch-Schönlein purpura (HSP) during treatment with fluoxetine. Results: This 8-year-old boy suffered from depression about 3 months after he entered a new school. He visited a psychiatric clinic and fluoxetine was prescribed. The response was good and he went back to school smoothly. Sixth weeks later, he developed purpuric rash over bilateral lower extremities which extended to buttock and hands in two days. Mild painful swelling over left ankle was also noted when he was admitted. The investigations were normal including complete blood cell & platelet count, blood biochemistry, liver function tests, prothrombin time, partial thromboplastin time, serum immunoglobulin A and fibrinogen level. Yet D-dimer level was elevated to 8927 μg/dl (normal＜500), consistent with vasculitis. The diagnosis of HSP was made and fluoxetine ceased. Treatment was given with Prednisolone and Ranitidine, after which the purpura resolved in one week. Conclusions: HSP related to fluoxetine medication has rarely been reported in the young adults. Our case may attribute to be the youngest one who receives fluoxetine therapy and give us an example of the potential adverse effect of fluoxetine to the children.

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“…[13][14][15][16][17] There are numerous case reports in the literature of patients with truncal rash and concomitant renal involvement. [18][19][20][21][22][23][24][25][26][27][28] In a retrospective study of 57 adult cases of biopsy-confirmed HSP, Tancrede-Bohin et al [15] were able to show a significant association between IgA glomerulonephritis and the spread of purpura to areas above the waist. Hung et al [17] have shown that purpura extends above the umbilicus more commonly in children with a urinalysis abnormality lasting >1 year as compared with children in whom urinalysis abnormalities resolved within 1 year, suggesting increased renal involvement when truncal purpura is present.…”

Section: Discussionmentioning

confidence: 99%

Periumbilical Purpura Prior to Gastrointestinal Involvement in Henoch-Schönlein Purpura

Brown

Haught

English

2009

American Journal of Clinical Dermatology

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Henoch-Schönlein purpura (HSP) is a systemic vasculitis involving the skin, joints, gastrointestinal tract, and kidneys. While HSP is traditionally considered a disease of children, it also occurs in adults. In both populations, acute gastrointestinal complications and chronic renal involvement are major predictors of mortality. While it has been previously demonstrated that truncal lesions in HSP are associated with underlying renal involvement, a significant proportion of cases with gastrointestinal involvement also have associated truncal lesions. It is unclear at this time whether or not the association of truncal involvement with visceral disease is related to an increased burden of circulating immune complexes or a more specific mechanism. We describe a report of periumbilical purpura antecedent to gastrointestinal involvement in an adult with HSP.

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Acenocoumarol-Induced Henoch-Schönlein Purpura

Abstract: This case report illustrates a probable association between Henoch-Schönlein purpura and acenocoumarol. As of December 2003, this reaction had not been previously reported. Clinicians should be aware of this potential adverse effect of a widely used drug.

Cited by 19 publications

References 19 publications

Warfarin-induced Leukocytoclastic Vasculitis: A Case Report and Review of Literature

Warfarin-induced Leukocytoclastic Vasculitis: A Case Report and Review of Literature

Henoch-Scholein Purpura Related to Fluoxetine Medication in a Child

Periumbilical Purpura Prior to Gastrointestinal Involvement in Henoch-Schönlein Purpura

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