Acenocoumarol in Thromoembolic Disorders

Acenocoumarol’s pharmacokinetic: linear or not?

“…R (+) enantiomer is several times more potent than the S (-) enantiomer (Godbillon et al, 1981[1]). Acenocoumarol is rapidly absorbed following oral absorption with approximately 60 % of the dose available systemically (Trailokya, 2015[13]). After a single dose of 10 mg, the peak plasma concentrations (C max ) of acenocoumarol are reached within 1-3 h and the area under the plasma concentration-time curve (AUC) values are proportional to the dose in the dosage range of 8 to 16 mg (Sasso et al, 2012[8]).…”

“…The protein binding of acenocoumarol is 98 % (Trailokya et al, 2016[14]). Acenocoumarol is mainly metabolized by CYP2C9 (Trailokya, 2015[13]); 6- and 7-hydroxylation of both enantiomers of acenocoumarol are the major metabolites (Thijssen et al, 2000[11]). The elimination half-life of acenocoumarol is 8 to 11 h (Sánchez et al, 2013[7]).…”

“…Approximately, 29 % of acenocoumarol excrete in feces and 60 % in urine. The starting dose of acenocoumarol usually ranged from 2 to 4 mg. Based on the prothrombin time, subsequent loading doses may be recommended (Trailokya, 2015[13]).…”

“…Acenocoumarol is reported to exhibit a dose-proportional pharmacokinetics for the 8 to 16 mg doses (Trailokya, 2015[13]). However, no information is available for the dose-proportionality of lower doses of acenocoumarol (i.e.…”

Role of Patient Education and Counseling in Acenocoumarol Management

“…Thromboembolic disorders are very common across world, frequently a leading cause of death. Appropriate use of Anticoagulant plays an important role in management of prevention and treatment thromboembolic disorders [1].…”