Acellular matrix as a substrate for tissue-engineered graft of heart valve

Попандопуло, А. Г.; Петрова, М. С.

doi:10.22494/cot.v1i1.47

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…Recellularization of the valve with cells may reduce the immune response to an implanted tissue (Schmidt and Hoerstrup, ) and inhibit tissue calcification (Cebotari et al , ; Schoen and Levy, ), due to the normal calcium and phosphorus metabolism inside the cell‐seeded tissue (Popandopulo and Petrova, ). The coverage of DHV with viable cells inhibits thrombosis (Cebotari et al , ; De Visscher et al , ).…”

Section: Impediments To the Application Of Dhvsmentioning

confidence: 99%

Engineering natural heart valves: possibilities and challenges

Namiri

Ashtiani

Mashinchian

et al. 2016

J Tissue Eng Regen Med

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Heart valve replacement is considered to be the most prevalent treatment approach for cardiac valve-related diseases. Among current solutions for heart valve replacement, e.g. mechanical and bioprosthetic valves, the main shortcoming is the lack of growth capability, repair and remodelling of the substitute valve. During the past three decades, tissue engineering-based approaches have shown tremendous potential to overcome these limitations by the development of a biodegradable scaffold, which provides biomechanical and biochemical properties of the native tissue. Among various scaffolds employed for tissue engineering, the decellularized heart valve (DHV) has attracted much attention, due to its native structure as well as comparable haemodynamic characteristics. Although the human DHV has shown optimal properties for valve replacement, the limitation of valve donors in terms of time and size is their main clinical issue. In this regard, xenogenic DHV can be a promising candidate for heart valve replacement. Xenogenic DHVs have similar composition to human valves, which will overcome the need for human DHVs. The main concern regarding xenogeneic DHV replacement is the immunological reaction and calcification following implantation, weak mechanical properties and insufficient recellularization capacity. In this review, we describe the essential steps required to address these impediments through novel engineering approaches. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Impediments To the Application Of Dhvsmentioning

confidence: 99%

Engineering natural heart valves: possibilities and challenges

Namiri

Ashtiani

Mashinchian

et al. 2016

J Tissue Eng Regen Med

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show abstract

“…All of them can be assembled into two main groups: methods, suggesting the use of substances that cause necrosis; and methods allowing decellularization by inducing apoptotic cell death. Both groups have their pros and cons [10][11][12][13][14][15].…”

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confidence: 99%

Tissue engineering of vascular/valvular equivalents on the base of the xenogeneic decellularized matrix

Savchuk¹

2014

Biopolym. Cell

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According to the WHO, in 2008 cardiovascular diseases claimed the lives of 17.5 million people (30 % of all diseases). Often the only option to save a patient's life is a replacing the injured part of an organ by the prosthesis. Aim. This research was aimed to produce biomodificated cardiovascular graft by decellularisation of porcine heart valve. Methods. Our method of decellularization permits to make morphologically and physically non-modified decellularised extracellular matrix. Results. The analysis of matrix shows a decrease of the total number of cells, preservation of the collagen and elastin fibers structure, and safety of physiological adhesion. Conclusions. The matrix can be used as a framework for the vessel-valvular tissue-engineering prosthesis after its recellularization by the recipient's autologous cells.

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Acellular matrix as a substrate for tissue-engineered graft of heart valve

Cited by 2 publications

References 15 publications

Engineering natural heart valves: possibilities and challenges

Engineering natural heart valves: possibilities and challenges

Tissue engineering of vascular/valvular equivalents on the base of the xenogeneic decellularized matrix

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