Acellular Dermal Matrix Use in Cleft Palate and Palatal Fistula Repair

Ağır, Hakan; Eren, Gamze; Yaşar, Emrah Kağan

doi:10.1097/scs.0000000000001814

Cited by 30 publications

(28 citation statements)

References 15 publications

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“…), [2] but can also contain nontrivial concentrations of endogenous bioactive agents including growth factors. [1,3–6] Because of their composition and inherent ability to induce new tissue formation and regeneration, dECMs derived from human skin, [7] amnion, [8] nerve, [9] and demineralized bone [10] have been in successful clinical use for many years. This long track record and acceptance by clinicians is indicative of the promise of new ECM-based biomaterials that can be applied to repair or regenerate damaged, missing, or dysfunctional tissues and organs without activating host immune response, [1] or even serve as model materials for in vitro healthy or diseased tissue modeling.…”

Section: Introductionmentioning

confidence: 99%

“Tissue Papers” from Organ‐Specific Decellularized Extracellular Matrices

Jakus

Laronda

Rashedi

et al. 2017

Adv Funct Materials

107

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Using an innovative, tissue-independent approach to decellularized tissue processing and biomaterial fabrication, the development of a series of “tissue papers” derived from native porcine tissues/organs (heart, kidney, liver, muscle), native bovine tissue/organ (ovary and uterus), and purified bovine Achilles tendon collagen as a control from decellularized extracellular matrix particle ink suspensions cast into molds is described. Each tissue paper type has distinct microstructural characteristics as well as physical and mechanical properties, is capable of absorbing up to 300% of its own weight in liquid, and remains mechanically robust (E = 1–18 MPa) when hydrated; permitting it to be cut, rolled, folded, and sutured, as needed. In vitro characterization with human mesenchymal stem cells reveals that all tissue paper types support cell adhesion, viability, and proliferation over four weeks. Ovarian tissue papers support mouse ovarian follicle adhesion, viability, and health in vitro, as well as support, and maintain the viability and hormonal function of nonhuman primate and human follicle-containing, live ovarian cortical tissues ex vivo for eight weeks postmortem. “Tissue papers” can be further augmented with additional synthetic and natural biomaterials, as well as integrated with recently developed, advanced 3D-printable biomaterials, providing a versatile platform for future multi-biomaterial construct manufacturing.

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Section: Introductionmentioning

confidence: 99%

“Tissue Papers” from Organ‐Specific Decellularized Extracellular Matrices

Jakus

Laronda

Rashedi

et al. 2017

Adv Funct Materials

107

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“…Many authors have reported the use of ADM for fistula repairs (Losee and Smith, 2011; Aldekhayel et al, 2012; Zhang et al, 2014; Agir et al, 2015). Clark et al (2003) was the first to report the use of ADM in primary cleft palate repair.…”

Section: Discussionmentioning

confidence: 99%

The Use of Acellular Dermal Matrix in Combination With Pedicled Buccal Fat Pad in Wide Cleft Palate Repair: A Case Report and Literature Review

Goh

Chia

2019

The Cleft Palate-Craniofacial Journal

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We describe a case of the combined use of acellular dermal matrix and pedicled buccal fat pad (BFP) in a wide U-shaped cleft palate repair. Acellular dermal matrix was used as a “patch” repair for the nasal mucosa defect as opposed to the conventional inlay graft. The advantages include reduced cost and a smaller avascular graft load. Lateral relaxing incisions were made to ensure tension-free closure of oromucosa at midline. Lateral oromucosa defect closure with well-vascularized pedicled BFP ensures enhanced healing, less palatal contracture and shortening, and reduced infection. The palate healed with mucosalization at 2 weeks, and no complications were noted at 6 months follow-up.

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“…These results are favorable compared with both non-ADM fistula repair recurrence rates (33–37%), 19 , 28 and the most recent reports of fistula repair with ADM (20–33%). 26 , 29 …”

Section: Discussionmentioning

confidence: 99%

Cleft Palate Fistula Closure Utilizing Acellular Dermal Matrix

Emodi

et al. 2018

Plastic and Reconstructive Surgery - Global Open

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Summary:Fistulas represent failure of cleft palate repair. Secondary and tertiary fistula repair is challenging, with high recurrence rates. In the present retrospective study, we review the efficacy of using acellular dermal matrix as an interposition layer for cleft palate fistula closure in 20 consecutive patients between 2013 and 2016. Complete fistula closure was obtained in 16 patients; 1 patient had asymptomatic recurrent fistula; 2 patients had partial closure with reduction of fistula size and minimal nasal regurgitation; 1 patient developed a recurrent fistula without changes in symptoms (success rate of 85%). We conclude that utilizing acellular dermal matrix for cleft palate fistula repair is safe and simple with a high success rate.

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Acellular Dermal Matrix Use in Cleft Palate and Palatal Fistula Repair

Cited by 30 publications

References 15 publications

“Tissue Papers” from Organ‐Specific Decellularized Extracellular Matrices

“Tissue Papers” from Organ‐Specific Decellularized Extracellular Matrices

The Use of Acellular Dermal Matrix in Combination With Pedicled Buccal Fat Pad in Wide Cleft Palate Repair: A Case Report and Literature Review

Cleft Palate Fistula Closure Utilizing Acellular Dermal Matrix

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