“…The cytotoxic effects could be particularly concerning in the context of acellular dermal matrix (ADM) use in breast prosthetic surgery because povidone-iodine could potentially impact ADM incorporation, which then could lead to reconstructive failure. In their article, “Betadine Soaking of Silicone Coupons Minimally Impacts Acellular Dermal Matrix Incorporation in a Preclinical Primate Model,” 1 Nahabedian et al have attempted to address this safety concern with povidone-iodine.…”