Acellular Dermal Matrix Seeded with Adipose-Derived Stem Cells as a Subcutaneous Implant

Orbay, Hakan; Yasuda, Takami; Hyakusoku, Hiko; Mizuno, Hiroshi

doi:10.1007/s00266-011-9683-2

Cited by 44 publications

(32 citation statements)

References 35 publications

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“…In order to reduce this complication, experimental animal trials have been carried out in which an acellular dermal matrix was covered with a layer of ADSCs. The results indicate that the addition of stem cells decreases the tissue atrophy level and contributes to the preservation of the graft in long-term follow-ups [27].…”

Section: The Use Of Selected Sc Fractions In Plastic and Reconstructimentioning

confidence: 80%

The Use of Stem Cells in Plastic and Reconstructive Surgery

Koźlik

Wójcicki

2014

Adv Clin Exp Med

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As part of their clinical practice, plastic surgeons perform procedures in the fields of skin and adipose tissue grafting, the reconstruction of compound tissue loss and congenital malformations, the treatment of acute and chronic wounds and burns, as well as cosmetic surgery. On account of the great expectations associated with their use in therapy, stem cells (SCs) are increasingly frequently employed in in vitro experiments, animal models and clinical trials. The most commonly utilized SCs for these purposes are adult stem cells (AS), which are present in small amounts in every tissue; among these are two types of cells: bone marrow mesenchymal stem cells (BM-MSCs) and adipose-derived stem cells (ADSCs). The aim of this review is to present current findings in experimental research on the use of stem cells in the field of plastic and reconstructive surgery. Many studies have described the progress of trials using ADSCs and BM-MSCs mainly in the treatment of compound tissue loss and chronic wounds. The use of their paracrine, proangiogenic and osteogenic functions is emphasized. However, because of the very high harvesting and culturing expenses and the limited availability of data on their safety for human use, SCs are not a first-choice therapy. Further developments in SC research and gradually decreasing costs mean that along with commercial-scale SC culturing, the use of SCs will become a viable alternative to traditional surgical procedures (Adv Clin Exp Med 2014, 23, 6, 1011-1017).

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Section: The Use Of Selected Sc Fractions In Plastic and Reconstructimentioning

confidence: 80%

The Use of Stem Cells in Plastic and Reconstructive Surgery

Koźlik

Wójcicki

2014

Adv Clin Exp Med

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“…In addition, a large field of research has developed suggesting the use of ASCs in epidermal and/or dermal regeneration. Increased collagen content is measured upon subcutaneous implantation of rat ASCs seeded on decellularized dermal matrix [285]. Furthermore, Trottier et al 2008 show that skin grafts made through their "selfassembly" approach, and containing human ASCs in the dermal layer, graft well onto athymic mice and result in the production of a well-organized epidermis in vivo [136].…”

Section: In Vivo Ectoderm Regeneration-epithelial and Epidermalmentioning

confidence: 99%

Adipose-Derived Stem Cells in Tissue Regeneration: A Review

2013

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In 2001, researchers at the University of California, Los Angeles, described the isolation of a new population of adult stem cells from liposuctioned adipose tissue. These stem cells, now known as adipose-derived stem cells or ADSCs, have gone on to become one of the most popular adult stem cells populations in the fields of stem cell research and regenerative medicine. As of today, thousands of research and clinical articles have been published using ASCs, describing their possible pluripotency in vitro, their uses in regenerative animal models, and their application to the clinic. This paper outlines the progress made in the ASC field since their initial description in 2001, describing their mesodermal, ectodermal, and endodermal potentials both in vitro and in vivo, their use in mediating inflammation and vascularization during tissue regeneration, and their potential for reprogramming into induced pluripotent cells.

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“…Orbay et al [22] presented an acellular dermal matrix seeded with ASC as subcutaneous implant in a rat model. Enhanced stability and vascularization of the construct compared with a non-seeded control was demonstrated.…”

Section: Discussionmentioning

confidence: 99%