Aceclofenac-Induced Stevens-Johnson Syndrome After One Single Dose: A Maiden Case Report

Abstract

Drugs are known to cause various adverse drug reactions involving major organ systems. Skin-related adverse reactions are very common and range from a simple rash to life-threatening condition like Stevens-Johnson syndrome. Various drugs are known to cause skin reactions which include antiepileptics, analgesics, antibiotics, and proton-pump inhibitors. Nonsteroidal anti-inflammatory drugs causing life-threatening conditions such as Stevens-Johnson syndrome and toxic epidermal necrolysis are very rare and only few case reports are published. Hence, we report a case of Aceclofenac-induced Stevens-Johnson syndrome after single time administration in a tertiary care hospital in India.

Sulfadiazine induced Stevens Johnson syndrome in toxoplasmosis patient: a case report

“…Stevens johnson syndrome is the remarkable, serious life threatening cutaneous illness. 5 The International classification uses affected body surface area for the diagnosis of SJS/TEN, epidermal detachment of >30% of body surface area defines toxic epidermal necrolysis, stevens johnson syndrome represents <10% of body surface area and also 10-30% of body surface area represents stevens johnson syndrome/toxic epidermal necrosis (SJS/TEN) overlap. 6 Stevens johnson syndrome can occur in any age group but more frequently in the women and HIV-Infected patients.…”

“…8 SJS/TEN are usually diagnosed by clinical structures and histopathological examination. 5,6 Treating symptomatically is the only way to enhance the patient safety there is no particular guidelines for the treatment of SJS physicians and dermatologist treat the affected patients on availability of their knowledge and from their own experience. 9 The study carried out by Patel et al revealed that there is very little published information regarding Sulfadiazine -induced toxic epidermal necrolysis.…”