Acebutolol in hypertension‐double‐blind trial against placebo.

Abstract

1. Eleven hypertensive patients were studied in a double‐blind comparison of acebutolol, a beta‐adrenoceptor blocker, and placebo. 2. Optimum dosage defined in an open assessment varied from 200–600 mg twice daily. 3. Blood pressure and pulse rate fell significantly while patients were lying, standing and after exercise. 4. Blood pressure remained as well controlled on each patient's optimum daily dose when taken once daily, and assessed 24 h post dose. 5. There was no correlation between blood pressure reduction and changes in heart rate. On once daily therapy while blood pressure remained unchanged at 24 h post dose there was a signficant reduction in beta‐adrenoceptor blockade as measured by percentage reduction in exercise tachycardia. 6. There was no significant change in urinary catecholamine excretion or echocardiographically estimated cardiac output. 7. A correlation was found between the change in plasma renin activity (log transformed) and blood pressure reduction.

The lowering of daytime blood pressures with a single daily dose of acebutolol in ambulant hypertensives

“…In clinical studies, acebutolol has been shown to be an effective antihypertensive agent when given as a single daily dose (Ashton, 1977(Ashton, -1978Baker et al, 1979;Leary et al, 1978;Martin et al, 1978). In the present study, significant reductions in heart rate, systolic and diastolic pressure were observed for only 2 to 11 h after the single oral daily dose of 800 mg acebutolol.…”

Effects of beta blockade with acebutolol on hypertension, hemodynamics, and fluid volume

“…activity. \, 7,13,14 Menard et al 14 reported that reduction in arterial pressure correlates with initial plasma renin activity and that a fall in plasma renin activity within 48 hr after the initial oral dose of the drug was predictive of a long-term response to the drug.…”