ACE2 models of frequently contacted animals provide clues of their SARS‐CoV‐2 S protein affinity and viral susceptibility

Ma, Cheng; Gong, Caixia

doi:10.1002/jmv.26953

Cited by 12 publications

(16 citation statements)

References 39 publications

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“…Additionally, the clinical respiratory tract infections show similarities [30]. Because of all these resemblances, BCoV has already been suggested and successfully employed as a SARS-CoV(-2) surrogate in many different applications [35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53].…”

Section: Discussionmentioning

confidence: 99%

High Intensity Violet Light (405 nm) Inactivates Coronaviruses in Phosphate Buffered Saline (PBS) and on Surfaces

2021

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It has been proven that visible light with a wavelength of about 405 nm exhibits an antimicrobial effect on bacteria and fungi if the irradiation doses are high enough. Hence, the question arises as to whether this violet light would also be suitable to inactivate SARS-CoV-2 coronaviruses. Therefore, a high-intensity light source was developed and applied to irradiate bovine coronaviruses (BCoV), which are employed as SARS-CoV-2 surrogates for safety reasons. Irradiation is performed in virus solutions diluted with phosphate buffered saline and on steel surfaces. Significant virus reduction by several log levels was observed both in the liquid and on the surface within half an hour with average log reduction doses of 57.5 and 96 J/cm2, respectively. Therefore, it can be concluded that 405 nm irradiation has an antiviral effect on coronaviruses, but special attention should be paid to the presence of photosensitizers in the virus environment in future experiments. Technically, visible violet radiation is therefore suitable for coronavirus reduction, but the required radiation doses are difficult to achieve rapidly.

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Section: Discussionmentioning

confidence: 99%

High Intensity Violet Light (405 nm) Inactivates Coronaviruses in Phosphate Buffered Saline (PBS) and on Surfaces

2021

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“…There are several other species, for example, cats, dogs, or minks, that are also susceptible to SARS-CoV-2, but they have differences in the ACE2 receptors sequences. Moreover, the previous studies revealed evidence that the human ACE2 receptor has the highest binding affinity to SARS-CoV-2 compared to other animal species [ 14 – 16 ]. Those differences should be taken into consideration during animal SARS-CoV-2 infection studies.…”

Section: Animal Models For Sars-cov-2mentioning

confidence: 99%

Mouse models in COVID-19 research: analyzing the adaptive immune response

Clever

Volz

2022

Med Microbiol Immunol

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The emergence of SARS-CoV-2, the severe acute respiratory syndrome coronavirus type 2 causing the COVID-19 pandemic, resulted in a major necessity for scientific countermeasures. Investigations revealing the exact mechanisms of the SARS-CoV-2 pathogenesis provide the basis for the development of therapeutic measures and protective vaccines against COVID-19. Animal models are inevitable for infection and pre-clinical vaccination studies as well as therapeutic testing. A well-suited animal model, mimicking the pathology seen in human COVID-19 patients, is an important basis for these investigations. Several animal models were already used during SARS-CoV-2 studies with different clinical outcomes after SARS-CoV-2 infection. Here, we give an overview of different animal models used in SARS-CoV-2 infection studies with a focus on the mouse model. Mice provide a well-established animal model for laboratory use and several different mouse models have been generated and are being used in SARS-CoV-2 studies. Furthermore, the analysis of SARS-CoV-2-specific T cells during infection and in vaccination studies in mice is highlighted.

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“…SARS-CoV-2 foi detectado em cães domésticos (Canis familiaris) em diversos estudos, porém esses animais apresentam-se assintomáticos ou com sinais e sintomas leves durante a infecção (Sit et al, 2020;Hamer et al, 2022;Barroso-Arévalo et al, 2022;Jairak et al, 2022;Medkour et al, 2022;Rivero et al, 2022;Zambrano-Mila et al, 2022). Embora a afinidade do receptor ACE2 de cães para o SARS-CoV-2 seja considerada alta (Wu et al, 2020;Koley et al, 2021;Ma & Gong, 2021;Zhang et al, 2021), esse fator não é o único preditor de susceptibilidade ao vírus (Wu et al, 2020;Koley et al, 2021;Ma & Gong, 2021;Piplani et al, 2021). Patterson et al (2020) examinaram 919 cães domésticos na Itália no auge da pandemia nesse país, encontrando anticorpos contra o SARS-CoV-2 em 3,3% desses animais, porém nenhum cão foi positivo ao exame de PCR para a detecção de partículas virais.…”

Section: O Vison Europeu (Mustela Vison) E O Vison Americano (Neoviso...unclassified

Zoonose e zoonose reversa do SARS-CoV-2 sob a perspectiva da Saúde Única

Norberg¹,

Norberg²,

Mangiavacchi³

et al. 2022

RSD

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Zoonoses não se processam em um único sentido na dinâmica de infecção, de animais para humanos. Assim como outras doenças, já vem sendo demonstrada a capacidade de infecção de animais pelo SARS-CoV-2 a partir do contato com humanos. O objetivo desse trabalho é realizar uma revisão narrativa, através da análise da literatura científica atual, quanto à possibilidade de zoonose e zoonose reversa do SARS-CoV-2 sob a perspectiva de Saúde Única e possíveis implicações para o futuro da evolução do vírus. Pesquisas recentes apontam que o vírus mostrou potencial de zoonose reversa, infectando mamíferos em diversas partes do planeta. Mustelídeos, hamsters, felinos e primatas do velho mundo são os animais que apresentaram maior susceptibilidade ao SARS-CoV-2. A zoonose reversa do SARS-CoV-2 favoreceu o surgimento de variantes cujas mutações mostraram-se adaptadas às diversas características fisiológicas particulares das espécies animais afetadas, com capacidade de retorno ao ser humano. O SARS-CoV-2 provavelmente será persistente entre mamíferos após a onda pandêmica que afetou a humanidade. Processos de mitigação da zoonose e zoonose reversa do SARS-CoV-2 sob a perspectiva da Saúde Única requerem ações em três níveis: ambiente humano, relações entre humanos e animais domésticos ou cativos, e vigilância e controle do vírus circulante entre animais de vida livre.

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ACE2 models of frequently contacted animals provide clues of their SARS‐CoV‐2 S protein affinity and viral susceptibility

Cited by 12 publications

References 39 publications

High Intensity Violet Light (405 nm) Inactivates Coronaviruses in Phosphate Buffered Saline (PBS) and on Surfaces

High Intensity Violet Light (405 nm) Inactivates Coronaviruses in Phosphate Buffered Saline (PBS) and on Surfaces

Mouse models in COVID-19 research: analyzing the adaptive immune response

Zoonose e zoonose reversa do SARS-CoV-2 sob a perspectiva da Saúde Única

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