ACE inhibitors and pneumonia

Sekizawa, Kiyohisa; Matsui, Toshifumi; Nakagawa, Toshiaki; Nakayama, Katsutoshi; Sasaki, Hidetada

doi:10.1016/s0140-6736(05)60114-6

Cited by 170 publications

(110 citation statements)

References 2 publications

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“…Angiotensin converting enzyme (ACE) inhibitors (Sekizawa et al 1998), amantadine ) and cilostazol (Yamaya et al 2001b) are effective in the prevention of silent aspiration pneumonia. Substance P mediates the swallowing reflex and cough reflex; capsaicin (Ebihara et al 1993), capsiate (Yamasaki et al 2010), black pepper oil (Ebihara et al 2006) and red wine polyphenol can be useful in evoking the release of substance P. The temperature within the oral cavity (Watando et al 2004) and physical stimuli, such as the action of a toothbrush (Yoshino et al 2001), can also cause substance P to be released.…”

Section: How To Prevent the Need For Nursing Carementioning

confidence: 99%

New Lessons of Nurturing Life for Geriatric Patients

Butler

Fujii²,

Sasaki³

2012

Tohoku J. Exp. Med.

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Our new lessons of nurturing life to make happiness and well-being of geriatric patients suggest comprise several important steps. First, geriatric patient care should not be delegated to specialists who focus on individual organ system. Instead, we should respond to the patient's condition based on comprehensive assessment to identify the single pathogenesis. Second, we should appreciate that the behavioral and psychological symptoms of dementia (BPSD) often reflect the behavioral and psychological symptoms of the caregiver (BPSC), and in particular the caregiver's attitude. Third, pleasant stimulations to the limbic system should receive more emphasis than attempting brain training in atrophied portions of the neocortex. Fourth, we should aim not for "successful aging," but for "balanced aging." Fifth, we should rely less on drug-based therapy and utilize more non-pharmacologic approaches to appropriate therapy. Geriatric patients should be cared for based on our new lessons of nurturing life rather than the heavily medicalized treatment modalities that are in wide use today.

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Section: How To Prevent the Need For Nursing Carementioning

confidence: 99%

New Lessons of Nurturing Life for Geriatric Patients

Butler

Fujii²,

Sasaki³

2012

Tohoku J. Exp. Med.

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“…In fact, a markedly decreased cough reflex was observed in elderly patients with aspiration pneumonia [3,4]. Inversely, there is growing evidence that angiotensin-converting enzyme (ACE) inhibitors have beneficial effects on the prevention of pneumonia in elderly patients by improving both the impaired swallowing reflex and disturbed cough reflex [8,9]. Although the elevated levels of bradykinin and substance P by ACE inhibitors are thought to be the source of the cough, bradykinin and substance P play a role in setting the threshold for the cough and swallowing reflex in humans, resulting in reduction of the occurrence of pneumonia in the elderly.…”

Section: To the Editorsmentioning

confidence: 99%

“…Although the elevated levels of bradykinin and substance P by ACE inhibitors are thought to be the source of the cough, bradykinin and substance P play a role in setting the threshold for the cough and swallowing reflex in humans, resulting in reduction of the occurrence of pneumonia in the elderly. The beneficial effects of ACE inhibitors for older subjects with the risk of aspiration pneumonia should be widely noted [8,9].…”

Section: To the Editorsmentioning

confidence: 99%

Significance of chronic cough as a defence mechanism or a symptom in elderly patients with aspiration and aspiration pneumonia

Teramoto¹

2005

European Respiratory Journal

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“…Although the synthesis ability of substance P remained low, it was not metabolized due to the pressure of ACEinhibitor, and thus the substance P concentration was maintained in the pharynx and bronchus. The swallowing reflex and cough reflex were maintained, and thus the incidence rate of pneumonia was decreased (23). Conventional drugs can be used and are available by prescription.…”

Section: Silent Aspirationmentioning

confidence: 99%

Care for Older People

2003

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Aging is often seen as disadvantageous in humanhistory. However, longevity reduces medical costs of the whole life compared with that of short life. Therefore, in order to reduce medical cost, we have to take care of the elderly in order to promote health and longevity. Health problems in the elderly should be solved by both medical and elderly care facilities.However, few studies have analyzed the care problems of the elderly. In this review, we describe the recent methods of care for the elderly. (Internal Medicine 42: 932-940, 2003)

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ACE inhibitors and pneumonia

Cited by 170 publications

References 2 publications

New Lessons of Nurturing Life for Geriatric Patients

New Lessons of Nurturing Life for Geriatric Patients

Significance of chronic cough as a defence mechanism or a symptom in elderly patients with aspiration and aspiration pneumonia

Care for Older People

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