ACE Inhibitor–Induced Angioedema in Elderly African American Females Requiring Tracheostomy

Kupfer, Yizhak; Ramachandran, Kavan; Tessler, Sidney

doi:10.1016/s0027-9684(15)30563-0

Cited by 8 publications

(3 citation statements)

References 8 publications

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“…Both were in elderly African-American females, and tracheostomy was required to manage the airway. 83 In one, the angioedema persisted for 4 weeks following hospitalization, and in the second, the patient's angioedema persisted for at least 2 weeks following hospitalization.…”

Section: Discussionmentioning

confidence: 94%

A Case of Refractory Angioedema

Irwin

Longanecker

Bodenhamer

et al. 2022

J Intensive Care Med

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Angioedema is an acute disorder that affects mucous membranes and the deepest layers of the skin along with underlying tissue, marked by rapid swelling, large welts, and pain. There are 3 major subtypes of angioedema: mast-cell mediated, bradykinin-mediated, and multifactorial or unclear mechanism subtype. The most common subtype of bradykinin-mediated angioedema is ACE-inhibitor induced, which disproportionately affects African-Americans. It is most often self-limiting and usually responds to the withdrawal of the offending agent. The prolonged duration of angioedema is uncommon in the absence of a persistent stimulus, though it is more likely when there is an abnormality of the metabolic pathways, such as in hereditary angioedema or other gene polymorphisms affecting the complement system. We present a case of severe angioedema that persisted for over a month and required a tracheostomy to manage the airway.

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Section: Discussionmentioning

confidence: 94%

A Case of Refractory Angioedema

Irwin

Longanecker

Bodenhamer

et al. 2022

J Intensive Care Med

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“…ACEi can cause angioedema because of their ability to increase bradykinin. The incidence of angioedema is more frequent and severe in African Americans warranting close monitoring [25,38 ▪▪ ,49]. These drugs are contraindicated during the second and third trimesters of pregnancy because of their teratogenicity, which is why providers should recommend contraception and ensure proper and consistent education for hypertensive women of child-bearing age [50].…”

Section: Discussionmentioning

confidence: 99%

Tailoring the management of hypertension to comorbidities

Mendoza

Kachur

Lavie

2021

Current Opinion in Cardiology

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Purpose of reviewIn this article, we review the most current evidence for initiation and maintenance of various antihypertension (HTN) drug classes, including other misconceptions with respect to common comorbidities in patients with HTN. Recent findingsAlthough the currently available anti-HTN agents have broad applicability in treating HTN, additional agents, such as angiotensin receptor-neprilysin inhibitors and novel nonsteroidal mineralocorticoid antagonists, have recently gained clinical significance. In addition, there have been some anecdotal concerns regarding the adverse effects, indications, and risks of COVID-19 infection/mortality when using certain anti-HTN agents.

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“…2 This association is well established and can be life threatening, especially when involving the mucosal and submucosal layers of the upper airway. 3 ACE inhibitor induced angioedema is a rare side effect and figures range from 0.1% to 0.2% of patients being affected worldwide. 4 Angiotensin converting enzymes, also known as ACE inhibitors are regularly prescribed by doctors in the treatment of congestive heart failure and hypertension.…”

Section: Introductionmentioning

confidence: 99%

A case report looking at ACE inhibitors as the cause of angioedema during dental treatment

Raval

2014

Br Dent J

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Angiotensin converting enzymes, also known as ACE inhibitors are regularly prescribed by doctors in the treatment of congestive heart failure and hypertension. In this case report, we will be looking at the delayed onset of angioedema as a result of ACE inhibitors that occurred during dental treatment. We will discuss other causes of angioedema and its management and aim to raise awareness among clinicians to include this in their differential diagnosis of swellings around the mouth, particularly as it can mimic the initial response or be a prelude to an anaphylactic shock.

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ACE Inhibitor–Induced Angioedema in Elderly African American Females Requiring Tracheostomy

Cited by 8 publications

References 8 publications

A Case of Refractory Angioedema

A Case of Refractory Angioedema

Tailoring the management of hypertension to comorbidities

A case report looking at ACE inhibitors as the cause of angioedema during dental treatment

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