ACE I/D polymorphism study in a Cuban hypertensive population

Nápoles, Osmel Companioni; Castellanos, Miguel Sautié; Leal, Lester; Casalvilla, Racmar; Camacho, Hanlet; Ferrer, Annia; Cintado, Alberto; Villareal, Adelaida; Benítez, Jesús; Nazabal, Marcelo; Velasco, Javier García Pérez; Cabalé, Beatriz; Novoa, Lidia I; Dueñas, Marta

doi:10.1016/j.cca.2006.11.003

Cited by 17 publications

(6 citation statements)

References 21 publications

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“…Studies carried out in other populations have brought conflicting results for each polymorphisms evaluated and some of them have found absent or limited association for ACE [27–30] and ACE2 [24,31,32] polymorphisms, as in this study. Nevertheless the risk allele for hypertension indicated by robust metanalysis studies point out the D allele (or DD genotype)[16] of ACE I/D polymorphism; while for ACE2 G8790A polymorphism the findings are more controversial with the great majority of the studies conducted in China been pointed out the A allele (or AA genotype) as the susceptibility profile [33,34].…”

Section: Discussionmentioning

confidence: 47%

The combination of ACE I/D and ACE2 G8790A polymorphisms revels susceptibility to hypertension: A genetic association study in Brazilian patients

et al. 2019

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Background Systemic arterial hypertension (SAH) is a multifactorial condition that already affects one third of the worldwide population. The identification of candidate genes for hypertension is a challenge for the next years. Nevertheless, the small contribution of each individual genetic factor to the disease brings the necessity of evaluate genes in an integrative manner and taking into consideration the physiological interaction of functions. Angiotensin I–converting enzymes, ACE and ACE2, are key regulators of blood pressure that have counterbalance roles by acting on vasoactive peptides from Renin-Angiotensin-Aldosterone System (RAAS). Insertion/deletion (I/D) polymorphism of ACE gene and single nucleotide polymorphism G8790A of ACE2 gene have been associated with susceptibility to SAH, but the literature is controversial. We proposed to evaluate these two polymorphisms jointly exploring the combined effects of ACE and ACE2 genotypes on SAH susceptibility, an approach that have not been done yet for ACE and ACE2 polymorphisms. Methods and findings This genetic association study included 117 hypertensive (mean age 59.7 years) patients and 123 normotensive and diabetes-free controls (mean age 57.5 years). ACE and ACE2 polymorphisms were genotyped by SYBR Green real-time PCR and RFLP-PCR, respectively. Crude and adjusted odds ratio (OR) values were calculated to estimate the susceptibility to SAH development. It was obtained homogeneity regarding distribution by sex, age range, smoking, alcohol consumption and body mass index (BMI) between case and control groups. No-association was verified for each gene individually, but the combination of ACE and ACE2 polymorphisms on female gender revealed a significative association for DD/G_ carriers who had a 3-fold increased risk to SAH development (p = 0.03), with a stronger susceptibility on DD/GG carriers (7-fold increased risk, p = 0.01). The D allele of ACE showed association with altered levels of lipid profile variables on case group (VLDL-cholesterol, p = 0.01) and DD genotype in all individuals analysis (triglycerides, p = 0.01 and VLDL-cholesterol, p = 0.01). Conclusion These findings indicate that the combination of ACE and ACE2 polymorphisms effects may play a role in SAH predisposition been the DD/G_ genotype the susceptibility profile. This result allowed us to raise the hypothesis that an increased activity of ACE (prohypertensive effects) in conjunction with reduced ACE2 activity (antihypertensive effects) could be the underlining mechanism. The association of ACE D allele with lipid alterations indicate t...

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Section: Discussionmentioning

confidence: 47%

The combination of ACE I/D and ACE2 G8790A polymorphisms revels susceptibility to hypertension: A genetic association study in Brazilian patients

et al. 2019

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“…In Latin America, a study in Colombia (Bucaramanga) found that DD genotype was 1.56 times more frequent in hypertensive patients, compared to allele I [15]. Bonfim-Silva et al [16] in their study with Afro-Brazilian and Caucasian population found no association; neither did the study conducted in Cuba in a multi-ethnic sample [17]. A recent study in Brazil also found no relationship; however, this relationship became significant only when ACE and ACE2 polymorphisms were combined [18].…”

Section: Discussionmentioning

confidence: 85%

Lack of association between angiotensin-converting enzyme (ACE) genotype and essential hypertension in Peruvian older people

Oscanoa

Cieza

Caparó

et al. 2020

Arterial Hypertension

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“…In this study, we additionally took into account the facts that bisoprolol has a negative inotropic effect (Bazroon and Alrashidi, 2022), and reduces arterial stiffness as demonstrated, in particular, by a decrease in pulse wave velocity (Asmar et al, 1991;Kahonen et al, 2000;Palmieri et al, 2004;Ong et al, 2011;Zhou et al, 2013;Eguchi et al, 2015). A complete list of target points for all antihypertensive drugs, including actual ‫ܧ‬ -values used in the formula (2), is provided in the Supplementary File 2, Table S5. An extended model comprising all pharmacodynamic functions is available online (see Data Availability).…”

Section: Simulation Of Antihypertensive Treatmentmentioning

confidence: 99%

“…In addition to the above, it has been shown that ACE I/D polymorphism contribute to the development of hypertension in Swedes (Stefansson et al, 2000); North Indians (Sameer et al, 2010; Srivastava et al, 2012; Singh et al, 2016; Rana et al, 2018); Asian Indians (Das et al, 2008); residents of Gujarat, Western India (Patel et al, 2022); Saudi subjects (Ali et al, 2013); Russians (Kovaleva et al, 2019); indigenous ethnic group of Mountain Shoria, Russia (Barbarash et al, 2017); Japanese (Yoshida et al, 2000); Punjabi population from Faisalabad, Pakistan (Hussain et al, 2018); population of Burkina Faso, West Africa (Tchelougou et al, 2015); Ethiopian population, East Africa (Birhan et al, 2022); as well as Han, Kazakh, Tibetan, and Zhuang Chinese populations (Li, 2012; Sun et al, 2018). In contrast, the association between ACE I/D genotypes and hypertension has not been established in Slovenians (Glavnik and Petrovic, 2007); Buryats (Kovaleva et al, 2019); Thais (Charoen et al, 2019); Romany subjects and Slovaks (Danková et al, 2009); Cuban population, primarily of European and African ancestry, living in Havana (Nápoles et al, 2007); Algerian population from Oran (Meroufel et al, 2014); and some Chinese minorities, including Mongolians, Uyghurs, Yugurs, Koreans, and others (Li, 2012).…”

Section: Introductionmentioning

confidence: 99%

Mathematical modeling of the influence ofACE I/Dpolymorphism on blood pressure and antihypertensive therapy

Kutumova,

Kovaleva,

Sharipov

et al. 2024

Preprint

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The angiotensin converting enzyme (ACE) gene (ACE) insertion/deletion (I/D) polymorphism has attracted much attention in recent years, as it raises the hope of personalizing ACE inhibitor therapy to optimize its efficiency and reduce side effects for genetically distinct subgroups. However, the extent of its influence among these subgroups remains inconclusive. Therefore, we extended our computational model of blood pressure regulation to investigate the effect of theACE I/Dpolymorphism on hemodynamic parameters in humans and antihypertensive therapy. The model showed that the dependence of blood pressure on serum ACE activity is a function of saturation. Hence, a possible reason for the lack of association betweenACE I/Dand blood pressure levels could be a fairly high ACE activity in populations. Additionally, in an extended model simulating the effects of different classes of antihypertensive drugs, we explored the relationship betweenACE I/Dand the efficacy of inhibitors of the renin-angiotensin-aldosterone system. The model predicted that the response of cardiovascular and renal parameters to treatment directly depends on ACE activity. However, significant differences in parameter changes were observed only between groups with high and low ACE levels, whileACE I/Dgenotypes within the same group had similar changes in absolute values. We conclude that a single genetic variant is responsible for only a small fraction of heredity in treatment success, so its predictive value is limited.

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ACE I/D polymorphism study in a Cuban hypertensive population

Cited by 17 publications

References 21 publications

The combination of ACE I/D and ACE2 G8790A polymorphisms revels susceptibility to hypertension: A genetic association study in Brazilian patients

The combination of ACE I/D and ACE2 G8790A polymorphisms revels susceptibility to hypertension: A genetic association study in Brazilian patients

Lack of association between angiotensin-converting enzyme (ACE) genotype and essential hypertension in Peruvian older people

Mathematical modeling of the influence ofACE I/Dpolymorphism on blood pressure and antihypertensive therapy

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