ACE I/D polymorphism in Korean patients with ischemic stroke and silent brain infarction

Hong, Seung Ho; Park, H. M.; Ahn, Jung Yong; Kim, O. J.; Hwang, Tae Sun; Oh, Doyeun; Kim, N. K.

doi:10.1111/j.1600-0404.2007.00932.x

Cited by 19 publications

(7 citation statements)

References 23 publications

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“…At the genetic level, only a few genes have been reported as risk factors for SBI to date, which include apolipoprotein (a), methylenetetrahydrofolate reductase (MTHFR) angiotensinogen (AGT) and angiotensin II type 1 receptor (AT1R) (23,24,29). We have recently studied the role of angiotensin-converting enzyme (ACE) polymorphism in the development of stroke and SBI, and found that it is associated with stroke but not with SBI (25).…”

Section: Discussionmentioning

confidence: 99%

“…Considering the significance of SBI, which is known to increase the risk of developing into serious vascular diseases, such as stroke and dementia, there has been no epidemiological study on the eNOS polymorphisms in the SBI patients to our knowledge, although very few polymorphic studies of other genes have been reported (8,(23)(24)(25). Therefore, in the present study, we investigated the role of polymorphisms in the eNOS gene (-786T>C, 4a4b and 894G>T) as a risk factor for SBI.…”

Section: Introductionmentioning

confidence: 95%

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Endothelial nitric oxide synthase gene polymorphisms and the risk of silent brain infarction

Song

Kim²,

Bae³

et al. 2010

Int J Mol Med

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Abstract. Silent brain infarction (SBI), a unique cerebrovascular disorder, is frequently detected on magnetic resonance imaging (MRI) of apparently healthy elderly persons, and it is known to increase the risk of stroke and other related diseases. Although detailed mechanisms of SBI pathogenesis have yet to be determined, recent studies suggest that SBI is significantly influenced by genetic factors. In this study, we investigated polymorphisms in the endothelial nitric oxide synthase (eNOS) gene (i.e., -786T>C, 4a4b and 894G>T) as possible risk factors for SBI. We enrolled 269 patients with SBI and 234 control subjects and examined their fasting plasma homocysteine and folate levels, and analyzed for eNOS polymorphisms and haplotypes. The prevalence of SBI was shown to be significantly higher in patients with the eNOS 894GT genotype (OR, 2.00; 95% CI, 1.30-3.08) and 894GT+TT genotype (OR, 2.05; 95% CI, 1.34-3.16), compared with the 894GG genotype. However, in the case of -786T>C and 4a4b polymorphisms, no significant difference was observed between SBI patients and normal subjects. Interestingly, we found that the prevalence of SBI can increase twice as high when either -786T>C or 4a4b polymorphism was combined with 894G>T polymorphism, -786TC+CC/ 894GT+TT (OR, 3.83; 95% CI, 1.24-11.80) and 4a4b+4a4a/894GT+TT (OR, 4.08; 95% CI, 1.34-12.40), respectively. According to haplotype analysis, we found that three haplotypes (-786T-4b-894G, -786T-4b-894T and -786C-4a-894T) were shown to be significantly different between SBI patients and control subjects. These results indicate that eNOS polymorphisms and haplotypes serve as risk factors for SBI, and three different polymorphic loci in the eNOS gene play interactively, thereby leading to synergistic effects for the generation of SBI.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Endothelial nitric oxide synthase gene polymorphisms and the risk of silent brain infarction

Song

Kim²,

Bae³

et al. 2010

Int J Mol Med

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“…Genetic polymorphisms of MTHFR, eNOS, ACE, and ApoE were selected based on previous findings that have indicated that the polymorphisms have biological and clinical relevance. [10][11][12][13][14] For the MTHFR 677C.T, eNOS 1894G.T, and 2784T.C polymorphisms, genotyping was performed based on the method described by Loo et al 15 The MTHFR 1298A.C, eNOS intron 4a/b, ACE I/D, and ApoE polymorphisms were genotyped using methods described by Shi et al, 16 Xin et al, 17 Ramachandran, et al 18 and Pantelidis et al, 19 respectively, with slight modifications.…”

Section: Sampling Of Subjectsmentioning

confidence: 99%

Clinical Relevance of MTHFR, eNOS, ACE, and ApoE Gene Polymorphisms and Serum Vitamin Profile among Malay Patients with Ischemic Stroke

Wei

Menon

et al. 2015

Journal of Stroke and Cerebrovascular Diseases

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“…But recent studies show that the risk factor profile is not different in stroke subtypes questioning the validity of lacunar hypothesis [6][7][8]. Further data suggest that genetic predisposition might influence the type of stroke in patients with similar vascular risk factors [9].…”

Section: Introductionmentioning

confidence: 98%

Comparison of risk factors, severity and outcome between lacunar and non-lacunar stroke in a tertiary care center in Sri Lanka: A descriptive study

Perera¹,

Bandara²,

Ranasinghe³

et al. 2015

Ceylon Med. J.

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This study compares demography, risk factors and outcome of lacunar (LAC) and non-lacunar (non-LAC) strokes from the prospective hospital based stroke registry at Colombo South Teaching Hospital from 1 st March 2012 to 30 th June 2013. Data on admission, discharge and at 28 days after discharge were analysed. There were 229 ischaemic stroke (IS) patients. Average age was 65.7 years (SD 12.2, range 34-94) and 116 (50.7%) were males. LAC (n=130, 56.8%) were common than non-LAC (n=99, 43.2%). There were 75 (64.7%) males and 55 (48.7%) females in the LAC group (adjusted OR 2.1, 95% CI 1.08-4.29). Atrial fibrillation was less frequent among LAC stroke (OR 0.3, 95% CI 0.09-0.99). Hypertension, diabetes, smoking, dyslipidaemia did not differ in the two groups. Lower NIHSS (5.34 Vs 6.6, p= 0.053), higher GCS (14.7 Vs 13.3, p=0.001) were seen in LAC. Disability (MRS, Barthel index) on discharge, at 28 days and mortality during hospital stay and within 28 days was lower in the LAC group (p <0.001).

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ACE I/D polymorphism in Korean patients with ischemic stroke and silent brain infarction

Cited by 19 publications

References 23 publications

Endothelial nitric oxide synthase gene polymorphisms and the risk of silent brain infarction

Endothelial nitric oxide synthase gene polymorphisms and the risk of silent brain infarction

Clinical Relevance of MTHFR, eNOS, ACE, and ApoE Gene Polymorphisms and Serum Vitamin Profile among Malay Patients with Ischemic Stroke

Comparison of risk factors, severity and outcome between lacunar and non-lacunar stroke in a tertiary care center in Sri Lanka: A descriptive study

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