Introduction. Maintaining labor efficiency, working under conditions of stress and
uncertainty, high level of requirements to the functional state of workers in various
professions actualize the occupational health study of work performance. Methodological
applications of predictive medicine and psychogenetics make it possible to identify specific
hereditary (biological) predispositions of individuals, to carry out professional orientation
of a person, to provide humanistic recommendations on occupation of a certain type of
professional activity.
The study aims to identify a correlation between ACE genotypes and
work performance capability in individuals from a professional leadership community.
Materials and methods. Individuals from a professional leadership community, after dividing
into two cohorts consisting of entrepreneurs and non-entrepreneurs, were interviewed and
genotyped for evidence of genotype-by-insertion/deletion (I/D) polymorphism associations of
the angiotensin I converting enzyme (ACE) gene and health status. Answers to 4 questions
characterized the state of work performance and memory, and another 4 questions characterized
the cardiovascular system. The mean age was 37±1.7 years for entrepreneurs and 34.23±0.66
years for non-entrepreneurs. There were 44 females and 129 males among them.
Results.
Analysis of genotyping of 173 people (25 entrepreneurs and 148 non-entrepreneurs) revealed a
significant deviation of actual frequencies of I and D alleles from theoretically expected
values in the whole group of managers and between non-entrepreneurs (p=0.95, χ2>3.8). In
all groups, there was a marked increase in the frequency of the I/I genotype at the expense of
a decrease in the frequency of the D/D genotype compared to the literature data. A significant
difference between D/D and I/D genotypes in work performance was found in entrepreneurs
(p=0.9817), which coincides with a significant difference between their representatives by age
(p>0.99). Contrary to expectations, representatives of the D/D genotype, at least
entrepreneurs, demonstrated the most optimal level of functioning of the autonomic nervous
system. No associations were found between the genotype for the ACE gene (rs4646994) and work
performance and memory.
Conclusion. In the total sample of leaders and among the subgroup
of non-entrepreneurs, a strong and reliable change in the frequencies of alleles I and D was
found compared to the theoretically expected (frequencies). There was a significant increase
in the frequency of I/I genotype in all groups. The significant difference in the rates
between the D/D and I/D groups coincides with a significant difference between their
representatives in terms of age. According to the results of test answers, representatives of
entrepreneurs of D/D genotype had the most optimal level of vegetative nervous system
functioning.