Ace Gene Polymorphism Insertion Deletion Association with Prostate Cancer

Shubbar, Hasanain Ali; Umran, Mahfoodha A.

doi:10.25258/ijpqa.v9i2.13644

Cited by 2 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The insertion/deletion polymorphism of the ACE gene is directly related to ACE plasma levels [ 50 ]. This variation has also previously been found to be associated with LUTS or surgery for LUTS in study populations of Mexico and India [ 43 , 45 ]. Thus, such reports prove the robustness of the current study.…”

Section: Discussionsupporting

confidence: 61%

“… [ 42 ] India Asian 200 200 ACE I/D polymorphisms PCR 58.3 ± 6 57.6 ± 3.4 YES HB 5 3. [ 43 ] Iraq Caucasian 75 81 ACE I/D polymorphisms PCR-RFLP 56.4 ± 3.9 49.2 ± 6.1 YES HB 5 4. [ 44 ] Mexico Caucasian 20 38 ACE I/D polymorphisms PCR-RFLP NA NA Yes HB 5 …”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Systematic review and meta-analysis of candidate gene association studies of benign prostate hyperplasia

Lin

Li²,

Liu

et al. 2022

Syst Rev

View full text Add to dashboard Cite

Background Benign prostate hyperplasia (BPH) is the most common urological problem in elderly males. Recent studies have reported polymorphism in various metabolic genes in BPH. However, their association with the susceptibility of BPH is still inconsistent. Here, we systematically reviewed and performed a meta-analysis of CYP17, VDR, and ACE genes to determine their precise association with the risk of BPH. Methods A comprehensive literature search for published studies on candidate gene associations involving vitamin D receptor (VDR), angiotensin-converting enzyme (ACE), and CYP17 genes with the risk of BPH was done up to April 2020 in PubMed, Scopus, Cochrane Central Register of Controlled Trials (CENTRAL), and Google Scholar databases. Fixed/random effects models were used to estimate the odd’s ratio (OR) and 95% confidence intervals (CIs). Begg’s funnel plot was used to assess the potential for publication bias. Results We found a total of 23 studies containing 3461 cases and 3833 controls for these gene polymorphisms. A significant association of ACE gene polymorphism was observed under the recessive (II vs. ID + DD) model for BPH susceptibility compared to control subjects (overall OR = 1.67, 95% CI = 1.03–2.73). Similar trends were observed for ACE gene polymorphism in Caucasian (OR = 6.18, 95% CI = 1.38–27.68) and Asian (OR = 1.42, 95% CI = 0.99–2.03) populations under study. No significant association was observed in VDR and CYP17 gene polymorphisms in any dominant or recessive models. Conclusion Significant OR demonstrated the implication of ACE gene polymorphism in the proliferation of prostate tissue, which in turn is associated with BPH susceptibility. However, prospective studies at large scale and sample size are needed to confirm the current findings.

show abstract

Section: Discussionsupporting

confidence: 61%

Section: Resultsmentioning

confidence: 99%

Systematic review and meta-analysis of candidate gene association studies of benign prostate hyperplasia

Lin

Li²,

Liu

et al. 2022

Syst Rev

View full text Add to dashboard Cite

show abstract

“…Next, the full text of the remaining articles was reviewed. Finally, eight eligible literature was identified [10][11][12][16][17][18][19][20], including 817 patients with PCa and 6917 controls. Two of the eight [10,11] reported two different controls, so the two articles contained four studies.…”

Section: Search Results and Basic Characteristics Of Included Studiesmentioning

confidence: 99%

“…Finally, eight eligible literature was identified [10][11][12][16][17][18][19][20], including 817 patients with PCa and 6917 controls. Two of the eight [10,11] reported two different controls, so the two articles contained four studies. Finally, 10 studies were included in this meta-analysis, with eight studies in Caucasian populations, one in the Chinese population, and one in the Mexican population with basic characteristics in Table 1, with all included studies high-quality studies having NOS scores greater than six points.…”

Section: Search Results and Basic Characteristics Of Included Studiesmentioning

confidence: 99%

“…A meta-analysis by Wang et al [9] in 2018 determined a correlation between ACE I/D polymorphism and PCa susceptibility, but this study had significant limitations of a small number of included articles and inadequate robustness of the conclusion. Afterward, there are still many individual studies published on ACE I/D polymorphism and PCa susceptibility [10][11][12]. Therefore, this study used meta-analysis to investigate the association between the two in order to provide evidence-based medical evidence for proving whether ACE I/D polymorphism can be considered as a potential diagnostic and screening molecular biomarker in PCa patients.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association of angiotensin-converting enzyme insertion/deletion (ACE I/D) gene polymorphism with susceptibility to prostate cancer: an updated meta-analysis

Lan

Yang

et al. 2022

World J Surg Onc

View full text Add to dashboard Cite

Objective This meta-analysis aims to explore the association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and susceptibility to prostate cancer (PCa). Methods We searched studies related to ACE I/D polymorphism and susceptibility to PCa through PubMed, Web of Science, Embase, Cochrane Library, and Scopus databases from inception to June 1, 2022. Five gene models, including allelic, dominant, recessive, homozygote, and heterozygote models, were analyzed. The pooled odds ratio (OR) was calculated using Stata 15.0 software. Publication bias was judged by the funnel plot and Egger’s test, with the robustness of the findings verified by sensitivity analysis. Results Eight published articles (including ten studies) were identified. The pooled results showed that ACE I/D locus polymorphism was significantly correlated with the risk of PCa under all gene models except for the heterozygous model (D vs. I: OR= 1.58, 95% CI: 1.14–2.21; DD vs. DI+II: OR=1.68, 95% CI: 1.11–2.54; DD+DI vs. II: OR=1.76, 95% CI: 1.11–2.80; DI vs. II: OR= 1.44, 95% CI: 0.99–2.10; DD vs. II: OR= 2.12, 95% CI: 1.15–3.93). Subgroup analysis based on genotype frequencies in the control group meeting Hardy-Weinberg equilibrium showed statistically significant differences in all gene models. The funnel plot and Egger’s test indicated no publication bias. The sensitivity analysis verified the robustness of the conclusions obtained in this meta-analysis. Conclusion ACE I/D locus polymorphism correlates to PCa risk. Allele D, genotype DD+DI, and DD at the ACE I/D locus increase susceptibility to PCa and can therefore serve as a potential diagnostic and screening molecular marker for PCa patients.

show abstract

Ace Gene Polymorphism Insertion Deletion Association with Prostate Cancer

Cited by 2 publications

References 0 publications

Systematic review and meta-analysis of candidate gene association studies of benign prostate hyperplasia

Systematic review and meta-analysis of candidate gene association studies of benign prostate hyperplasia

Association of angiotensin-converting enzyme insertion/deletion (ACE I/D) gene polymorphism with susceptibility to prostate cancer: an updated meta-analysis

Contact Info

Product

Resources

About