Accurate motor mapping in awake common marmosets using micro-electrocorticographical stimulation and stochastic threshold estimation

Kosugi, Akito; Takemi, Mitsuaki; Tia, Banty; Castagnola, Elisa; Ansaldo, Alberto; Sato, Kenta; Awiszus, Friedemann; Seki, Kazuhiko; Ricci, Davide; Fadiga, Luciano; Iriki, Atsushi; Ushiba, Junichi

doi:10.1088/1741-2552/aab307

Cited by 5 publications

(13 citation statements)

References 46 publications

(50 reference statements)

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“…e neuroelectrophysiological monitoring technology can monitor the changes in the electrical signals transmitted by the nerves of the brain functional areas in real time and accurately locate the cortical functional areas, thereby improving the success rate and safety of surgery and reducing neurological damage [9,10]. Among them, the cortical microcurrent stimulation technology has high positioning accuracy, which can detect both cortical function and subcortical conduction pathways [11]. However, this technique requires the patient to remain fully awake, so it is necessary to wake up intraoperatively after general anesthesia.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Dexmedetomidine and Etomidate on Intraoperative Wake-Up Equality, Hemodynamics, and Cerebral Protection in Operation of the Brain Functional Area

Peng

Guan

2021

Evidence-Based Complementary and Alternative Medicine

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In recent years, with the increasing incidence of brain functional area tumors, the clinical application of functional area tumor resection has become extremely urgent. Intraoperative wake-up is an important auxiliary method of this operation, which can effectively reduce the damage of the brain function area caused by the operation and anesthesia itself while playing the role of auxiliary function area and tumor positioning. However, the intraoperative wake-up requires a higher anesthesia effect, so higher requirements are put forward for the choice of anesthetic drugs. Based on hemodynamic and serum molecular observations, this study found that dexmedetomidine- and etomidate-assisted anesthesia were used for intraoperative wake-up in brain functional area surgery, both of which could maintain hemodynamic stability. In addition, the arousal effect and brain protection of dexmedetomidine were better than those of etomidate, and the incidence of adverse reactions was lower during the arousal period. This can provide relevant reference for clinical improvement of the anesthesia effect and surgical safety of intraoperative wake-up.

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Section: Discussionmentioning

confidence: 99%

Comparison of Dexmedetomidine and Etomidate on Intraoperative Wake-Up Equality, Hemodynamics, and Cerebral Protection in Operation of the Brain Functional Area

Peng

Guan

2021

Evidence-Based Complementary and Alternative Medicine

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“…Preliminary direct comparison studies between epidural bipolar-biphasic-triple pulse and direct cortical monopolar stimulation resulted in similar MEPs. Advantages and limitations of the epidural cortical stimulation have been previously discussed by Kosugi et al (2018). Given that epidural stimulation is minimally invasive and that it activates pyramidal neurons transsynaptically via cortical interneuron activation, we used epidural bipolar-biphasic-triple pulse for our MEP recordings (Mishra et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…A reliable, minimally invasive, and quantitative motor mapping and MEP recording method in anesthesia-free conditions are warranted for elucidating the mechanisms underlying cortical motor reorganization. Establishing stable and reproducible conditions for RMT, AMT, and MEPs for long-term evaluations in awake, freely-moving rodents is also necessary (Kosugi et al, 2018 ). Furthermore, Hoogendam et al ( 2010 ) presented—in a critical review—seven lines of evidence suggesting that neuromodulation of the rTMS is a result of the induction of synaptic changes resembling long-term potentiation and depression (LTP and LTD).…”

Section: Discussionmentioning

confidence: 99%

Continuous Theta-Burst Stimulation Intensity Dependently Facilitates Motor-Evoked Potentials Following Focal Electrical Stimulation of the Rat Motor Cortex

Fujiki

Kawasaki

Fudaba

2020

Front. Neural Circuits

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Although theta-burst stimulation (TBS) is known to differentially modify motor cortical excitability according to stimulus conditions in humans, whether similar effects can be seen in animals, in particular rats, remains to be defined. Given the importance of experimental rat models for humans, this study explored this stimulation paradigm in rats. Specifically, this study aimed to explore corticospinal excitability after TBS in anesthetized animals to confirm its comparability with human results. Both inhibitionfacilitation configurations using paired electrical stimulation protocols and the effects of the TBS paradigm on motor-evoked potentials (MEPs) in rat descending motor pathways were assessed. Paired-stimulation MEPs showed inhibition [interstimulus interval (ISI): 3 ms] and facilitation (11 ms) patterns under medetomidine/midazolam/butorphanol (MMB) anesthesia. Furthermore, while ketamine and xylazine (K/X) anesthesia completely blocked facilitation at 11-ms ISI, inhibition at a 3-ms ISI was preserved. Continuous and intermittent TBS strongly facilitated MEPs depending on stimulus intensity, persisting for up to 25 min under both MMB and K/X anesthesia. These findings are similar to the intracortical inhibition and facilitation observed in the human motor cortex using paired-pulse magnetic stimulation, particularly the glutamate-mediated facilitation phase. However, different TBS facilitatory mechanisms occur in the rat motor cortex. These different TBS facilitatory mechanisms affect the comparability and interpretations of TBS between rat and human models.

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“…Marmosets MK1 and MK2 were also included in a study that examined grasping-and locomotion-related cortical activities (Tia et al 2017(Tia et al , 2021. Cortical mapping data in the horizontal posture were reported in our previous study (Kosugi et al 2018), which aimed to establish a reliable long-term mapping algorithm for marmosets. All experimental procedures were performed according to the guidelines of the Laboratory Animal Welfare Act and the Guide for the Care and Use of Laboratory Animals (National Institutes of Health, Bethesda, MD).…”

Section: Animalsmentioning

confidence: 99%

“…Unlike the common approach of modifying the sensory inputs directly into the forelimb, the current study uniquely explored the impact of the sensorimotor state of other body segments on the topographical motor representation of the forelimb muscles. To assess the dynamic aspect of M1 motor maps, we used a previously established fast and accurate motor mapping system (Takemi et al 2017; Kosugi et al 2018). This system minimizes temporal effects on the mapping results and can detect slight alterations in motor maps.…”

Section: Introductionmentioning

confidence: 99%

Posture-dependent modulation of marmoset cortical motor maps detected via rapid multichannel epidural stimulation

Takemi,

Tia,

Kosugi

et al. 2024

Preprint

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In this study, rapid topographical changes were detected in the forelimb motor maps in the primary motor cortex (M1) of awake marmoset monkeys using our previously developed accurate short-time stimulation mapping procedure (Takemi et al. 2017; Kosugi et al. 2018). The results revealed that although the hotspot (the location in M1 that elicited a forelimb muscle twitch with the lowest stimulus intensity) remained constant across postures, the stimulus intensity required to elicit the forelimb muscle twitch in the perihotspot region and the size of motor representations were posture-dependent. Hindlimb posture was particularly effective in inducing these modulations. The angle of the body axis relative to the gravitational vertical line did not alter the motor maps. These results provide a proof of concept that a rapid stimulation mapping system with chronically implanted cortical electrodes can capture the dynamic regulation of forelimb motor maps in natural conditions. The flexible nature of the motor maps necessitates the reconsideration of the results of motor control and neuroplasticity studies. Neural mechanisms regulating forelimb muscle representations in M1 by the hindlimb sensorimotor state warrant further exploration.

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Accurate motor mapping in awake common marmosets using micro-electrocorticographical stimulation and stochastic threshold estimation

Abstract: Using implanted µECoG electrode arrays and a modified motor threshold-hunting algorithm, we were able to achieve reliable motor mapping in common marmosets with the ECS system.

Cited by 5 publications

References 46 publications

Comparison of Dexmedetomidine and Etomidate on Intraoperative Wake-Up Equality, Hemodynamics, and Cerebral Protection in Operation of the Brain Functional Area

Comparison of Dexmedetomidine and Etomidate on Intraoperative Wake-Up Equality, Hemodynamics, and Cerebral Protection in Operation of the Brain Functional Area

Continuous Theta-Burst Stimulation Intensity Dependently Facilitates Motor-Evoked Potentials Following Focal Electrical Stimulation of the Rat Motor Cortex

Posture-dependent modulation of marmoset cortical motor maps detected via rapid multichannel epidural stimulation

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