2004
DOI: 10.1002/mas.20013
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Accurate mass measurements by Fourier transform mass spectrometry

Abstract: The capability for accurate mass measurements is an important attribute of Fourier transform mass spectrometry (FTMS). Unlike other instrumental methods in mass spectrometry, FTMS still offers significant opportunities to improve mass measurement accuracy (MMA), making it an area of research. This review covers the published literature in FTMS from the late 1970s to the present. We discuss the development and evolution of mass calibration that give accuracies in the low ppm range. We sketch the derivation and … Show more

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Cited by 122 publications
(133 citation statements)
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“…22 For example, Amster and co-workers developed a calibration curve to account for the difference between ion populations of the calibration spectrum and subsequent spectra resulting in <10 parts-per-million MMA. 23 calibration law which afforded <5 ppm MMA.…”
Section: Introductionmentioning
confidence: 99%
“…22 For example, Amster and co-workers developed a calibration curve to account for the difference between ion populations of the calibration spectrum and subsequent spectra resulting in <10 parts-per-million MMA. 23 calibration law which afforded <5 ppm MMA.…”
Section: Introductionmentioning
confidence: 99%
“…(For more information on ion population-dependent space charge-induced frequency shifts in FT-ICR MS, see the following and references therein [20][21][22][23][24][25][26].) Thus, calibration equations that account for ion number fluctuations should improve mass accuracy for FT-MS imaging experiments [23,[25][26][27][28][29][30][31][32][33]. However, it should be noted that such calibration equations do not take into account other interactions in the ICR cell, which can affect the measured frequency, such as image charge when ions approach the detection electrodes, instability of electric trapping fields or instability of the magnetic field.…”
Section: Introductionmentioning
confidence: 99%
“…Fourier-transform ion cyclotron resonance (FTICR) mass spectrometry, developed by Comisarow and Marshall [7,8], currently provides the best mass resolution and mass accuracy (Ͻ1 ppm) of all types of mass analyzers [9 -11] and has proven to be useful for protein identification by database searching [2,12]. Mass measurement accuracy (MMA) at the sub part-per-million (ppm) level using internal calibration [13,14] and several ppm using external calibration have been demonstrated [15,16], and these have led to much greater identification specificity, as described in recent reviews [17,18].For FTICR/MS, space-charge is the principal cause of mass measurement error [15,19,20]. The best MMA is obtained by using internal calibration, as this eliminates global space-charge effects [16].…”
mentioning
confidence: 99%