Accurate, fully-automated registration of coronary arteries for volumetric CT digital subtraction angiography

Razeto, Marco; Mohr, Brian; Arakita, Kazumasa; Schuijf, Joanne D.; Fuchs, Andreas; Kühl, Jørgen Tobias; Chen, Marcus Y; Kofoed, Klaus F.

doi:10.1117/12.2042775

Cited by 3 publications

(4 citation statements)

References 14 publications

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“…Registering images as different in appearance as coronary non-contrast and contrast data sets is difficult, and the most accurate registration method requires a certain level of similarity of appearance between data sets to register and align. Slight motion artifacts have been identified as the main reason for the different appearance, but the dose, blooming, position of the rotation gantry and contrast injection regime may all cause differences in appearance between two scans [13].…”

Section: Discussionmentioning

confidence: 99%

“…Alignment and subtraction of coronary images was performed using a dedicated algorithm, volumetric CT digital subtraction angiography (CTDSA) on the scanner console [13]. For CTDSA, two data sets were required: with and without coronary contrast enhancement.…”

Section: Methodsmentioning

confidence: 99%

“…The registration was a two-step process in which both non-rigid and rigid transformation was computed and applied: First, a dense-field non-rigid registration method was used to align the entire non-contrast volume to the contrast volume [14]. Second, calcified lesions and stents were identified in both data sets and a rigid registration was performed close to each calcification and stent as identified in the non-contrast data set [13]. The result of the subtraction was a 3D image volume in which coronary calcifications and stents had been removed leaving the contrast-enhanced blood in the lumen as the only high intensity material.…”

Section: Methodsmentioning

confidence: 99%

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Subtraction CT angiography improves evaluation of significant coronary artery disease in patients with severe calcifications or stents—the C-Sub 320 multicenter trial

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Subtraction CT angiography improves evaluation of significant coronary artery disease in patients with severe calcifications or stents—the C-Sub 320 multicenter trial

et al. 2018

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“…12 For CTDSA two sets of volumetric data were required: with and without contrast enhancement of the coronary artery lumen. Following sequential image acquisition the two datasets were aligned using a combined rigid and non-rigid-registration algorithm and the registered pre-contrast volume was subtracted from the post-contrast volume(figure 1).…”

Section: 1materials and Methodsmentioning

confidence: 99%

Feasibility of coronary calcium and stent image subtraction using 320-detector row CT angiography

Fuchs

Kühl

Chen

et al. 2015

Journal of Cardiovascular Computed Tomography

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Background The reader confidence and diagnostic accuracy of coronary CT angiography (CCTA) can be compromised by the presence of calcified plaques and stents causing blooming artifacts. Compared to conventional invasive coronary angiography(ICA), this may cause an overestimation of stenosis severity leading to false positive results. In a pilot study we tested the feasibility of a new coronary calcium image subtraction algorithm in relation to reader confidence and diagnostic accuracy. Materials and Methods Forty-three patients underwent clinically indicated ICA and CCTA using a 320–detector row CT. Median Agatston score was 510. Two datasets were reconstructed: a conventional CCTA (CCTAconv) and a subtracted CCTA (CCTAsub), where calcifications detected on non-contrast images were subtracted from the CCTA. Reader confidence and concordance with ICA for identification of >50% stenosis were recorded. We defined target segments on CCTAconv as motion free coronary segments with calcification/stent and low reader confidence. The impact of CCTAsub was assessed. No approval from the ethics committee was required according to Danish law. Results A total of 76 target segments were identified. The use of coronary calcium image subtraction improved the reader confidence in 66% of these segments. In target segments specificity (86% vs. 65%, p<0.01) and positive predictive value (71% vs. 51%, p=0.03) were improved using CCTAsub compared to CCTAconv, without loss in negative predictive value. Conclusions Our initial experience with coronary calcium image subtraction suggests that it is feasible and could lead to an improvement in reader confidence and diagnostic accuracy for identification of significant coronary artery disease.

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Assessment of Coronary Stenosis Using Coronary CT Angiography in Patients with High Calcium Scores: Current Limitations and Future Perspectives

Kang

2024

J Korean Soc Radiol

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Accurate, fully-automated registration of coronary arteries for volumetric CT digital subtraction angiography

Cited by 3 publications

References 14 publications

Subtraction CT angiography improves evaluation of significant coronary artery disease in patients with severe calcifications or stents—the C-Sub 320 multicenter trial

Subtraction CT angiography improves evaluation of significant coronary artery disease in patients with severe calcifications or stents—the C-Sub 320 multicenter trial

Feasibility of coronary calcium and stent image subtraction using 320-detector row CT angiography

Assessment of Coronary Stenosis Using Coronary CT Angiography in Patients with High Calcium Scores: Current Limitations and Future Perspectives

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