Accurate determination of 11 representative phthalates and di(2-ethylhexyl) terephthalate in polyvinyl chloride using isotope dilution-gas chromatography/mass spectrometry

Min, Sang-Won; Lim, Dong Kyu; Lee, Sunyoung; Kim, Jeongkwon; Baek, Song-Yee

doi:10.1016/j.chroma.2023.464454

Cited by 1 publication

(1 citation statement)

References 24 publications

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“…For instance, the isotope dilution method has been introduced as a powerful technique for enhancing the accuracy and precision of PAE quantification. By accurately quantifying the target analytes, isotope dilution contributes to the robustness of the analytical procedure, particularly in complex environmental matrices [ 94 , 95 , 96 ]. Ultra-high-performance liquid chromatography (UHPLC) coupled with high-resolution mass spectrometry (HRMS) has shown promise in achieving enhanced separation and detection capabilities as well [ 97 ].…”

Section: Emerging Trends and New Perspectivesmentioning

confidence: 99%

Unpacking Phthalates from Obscurity in the Environment

Baneshi,

Tonney-Gagne,

Halilu

et al. 2023

Molecules

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Phthalates (PAEs) are a group of synthetic esters of phthalic acid compounds mostly used as plasticizers in plastic materials but are widely applied in most industries and products. As plasticizers in plastic materials, they are not chemically bound to the polymeric matrix and easily leach out. Logically, PAEs should be prevalent in the environment, but their prevalence, transport, fate, and effects have been largely unknown until recently. This has been attributed, inter alia, to a lack of standardized analytical procedures for identifying them in complex matrices. Nevertheless, current advancements in analytical techniques facilitate the understanding of PAEs in the environment. It is now known that they can potentially impact ecological and human health adversely, leading to their categorization as endocrine-disrupting chemicals, carcinogenic, and liver- and kidney-failure-causing agents, which has landed them among contaminants of emerging concern (CECs). Thus, this review article reports and discusses the developments and advancements in PAEs’ standard analytical methods, facilitating their emergence from obscurity. It further explores the opportunities, challenges, and limits of their advancements.

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