Accurate characterization of pure silicon-substituted hydroxyapatite powders synthesized by a new precipitation route

Marchat, David; Zymelka, Maria; Coelho, Carlos; Grémillard, Laurent; Joly‐Pottuz, Lucile; Babonneau, Florence; Esnouf, C.; Chevalier, Jérôme; Bernache‐Assollant, Didier

doi:10.1016/j.actbio.2013.03.011

Cited by 85 publications

(92 citation statements)

References 110 publications

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“…La principale difficulté vient des précurseurs de silicium peu ou pas solubles qui conduisentà la précipitation de composés biphasés [4]. Desétapes préliminaires de solubilisation du silicium sous forme d'anion silicate en milieu aqueux semblent nécessairesà son incorporation directe dans l'apatite durant la précipitation [6].…”

Section: Apatites Carbonatées Ou Silicatéesunclassified

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Elaboration de biocéramiques phosphocalciques

Champion

Damia

Viana

et al. 2013

MATEC Web of Conferences

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Abstract. Calcium phosphate ceramics (hydroxyapatite, tricalcium phosphate) are commonly used as synthetic bone graft substitutes. The development of new ceramic implants with improved performances requires the mastering of many chemical and physical parameters involved in their processing: synthesis of specific powders, shaping of complex architectures, sintering and functionalization. This paper illustrates a few examples of the work in the field of processes of these calcium phosphate bioceramics for applications in bone tissue engineering.Résumé. Les céramiques phosphocalciques (hydroxyapatite, phosphate tricalcique) sont couramment utilisées comme implants synthétiques en substitution osseuse. Le développement de nouveaux implants céramiques aux performances accrues nécessite la maîtrise de nombreux paramètres chimiques et physiques intervenant dans leurs procédés d'élaboration : synthèse de poudres spécifiques, mise en forme d'architectures complexes contrôlées, frittage et fonctionnalisation. Cette contribution illustreà travers quelques exemples les travaux menés dans le domaine des procédés d'élaboration de ces biocéramiques phosphocalciques pour des applications en ingénierie des tissus osseux.

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Section: Apatites Carbonatées Ou Silicatéesunclassified

“…Il apparait difficile de densifier totalement des apatites silicatées contenant plus de 0,5 mole de silicium par frittage naturel. Des travaux récents ont montré que la présence de vapeur d'eau dans l'atmosphère semble jouer ici aussi un rôle en augmentant la stabilité thermique de ces apatites [6].…”

Section: Apatites Silicatéesunclassified

Elaboration de biocéramiques phosphocalciques

Champion

Damia

Viana

et al. 2013

MATEC Web of Conferences

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“…HA and Si 0.5 HA powders were prepared according to the protocol described in detail elsewhere [9]. Reagents ratio used to prepare the Si 0.5 HA powders were calculated according to the formula Ca 10 (PO 4 ) 5.5 (SiO 4 ) 0.5 (OH) 1.5 and a constant molar ratio Ca/(P+Si) equals to 10/6.…”

Section: Methodsmentioning

confidence: 99%

Physico-Chemical Characterization and <i>In Vitro</i> Biological Evaluation of Pure SiHA for Bone Tissue Engineering Application

Marchat

Bouet

Ludeckgen

et al. 2012

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Abstract. Studies about silicon-substituted hydroxyapatites exhibit several shortcomings that leave unanswered questions regarding the properties and subsequent biological outcomes generated by this biomaterial. Firstly, samples characterization is often incomplete, meaning that phase purity on the pellet surface is not assured. In fact, ceramic materials used in literature that are claimed to be pure are actually polluted through second phase as superficial polymerized silicate.In this study, we have successfully synthesized a phase-pure silicon hydroxyapatite powder Ca 10 (PO 4 ) 5.5 (SiO 4 ) 0.5 (OH) 1.5 (Si 0.5 HA) compressed this powder into pellets, sintered them, and evaluated the biological response of osteoblast cells (C3H10 line) seeded on the pellet surface. Besides, the solubility in aqueous media of HA and Si 0.5 HA pellets were determined through "static" experiments. These tests attempt to provide a comprehensive picture of the cellular response to the SiHA material, in order to determine the mechanism by which Si evokes the improved in vitro biological outcomes described in the literature. Results revealed first an equivalent solubility of Si 0.5 HA and HA pellets, and second that cells do not react favourably to the pure SiHA surface.

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“…In fact, ionic substitution may be beneficial because can hinder aggregation, may increase loading efficiency as a consequence of a higher charge density, and may enhance dissolution of the endocytosed particles [106]. Silicon substitution of HAp has also been explored for non-viral gene delivery because great changes of properties (e.g., morphology, cell parameters, surface properties, crystallinity and kinetics of dissolution) have been reported [118][119][120]. Shekhar et al [106] demonstrated that the structure of HAp could be retained up to a 18.6 mol % of substitution of phosphates by silicates but an amorphous phase (i.e., for silicate contents between 16.6 and 33.3 mol %) and even new hydrated calcium silicate phases were formed at higher degrees of substitution.…”

Section: Hydroxyapatite As Non-viral Gene Delivery Systemmentioning

confidence: 99%

Section: Hydroxyapatite As Non-viral Gene Delivery Systemmentioning

confidence: 99%

Biodegradable and Biocompatible Systems Based on Hydroxyapatite Nanoparticles

et al. 2017

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Abstract:Composites of hydroxyapatite (HAp) are widely employed in biomedical applications due to their biocompatibility, bioactivity and osteoconductivity properties. In fact, the development of industrially scalable hybrids at low cost and high efficiency has a great impact, for example, on bone tissue engineering applications and even as drug delivery systems. New nanocomposites constituted by HAp nanoparticles and synthetic or natural polymers with biodegradable and biocompatible characteristics have constantly been developed and extensive works have been published concerning their applications. The present review is mainly focused on both the capability of HAp nanoparticles to encapsulate diverse compounds as well as the preparation methods of scaffolds incorporating HAp. Attention has also been paid to the recent developments on antimicrobial scaffolds, bioactive membranes, magnetic scaffolds, in vivo imaging systems, hydrogels and coatings that made use of HAp nanoparticles.

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Accurate characterization of pure silicon-substituted hydroxyapatite powders synthesized by a new precipitation route

Abstract: -Pottuz, et al.. Accurate characterization of pure silicon-substituted hydroxyapatite powders synthesized by a new precipitation route. Acta Materialia, Elsevier, 2013, 9 (6)

Cited by 85 publications

References 110 publications

Elaboration de biocéramiques phosphocalciques

Elaboration de biocéramiques phosphocalciques

Physico-Chemical Characterization and <i>In Vitro</i> Biological Evaluation of Pure SiHA for Bone Tissue Engineering Application

Biodegradable and Biocompatible Systems Based on Hydroxyapatite Nanoparticles

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