Accurate analog temperature control of a thin film microheater on glass substrate for lab-on-chip applications

Scorzoni, A.; Tavernelli, Michele; Placidi, P.; Valigi, Paolo; Nascetti, A.

doi:10.1109/icsens.2014.6985228

Cited by 4 publications

(1 citation statement)

References 6 publications

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“…In this case, the electronic circuit driving the heater and controlling the temperature is based on the variation of the heater resistance with temperature controlled through the analog circuit reported in [33]. The control circuit is based on a single operational amplifier fed with a single supply voltage.…”

Section: B Dsdna Separation On Chipmentioning

confidence: 99%

Integrated Sensor System for DNA Amplification and Separation Based on Thin Film Technology

Costantini

Petrucci

Lovecchio

et al. 2018

IEEE Trans. Compon., Packag. Manufact. Technol.

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This paper presents the development of a lab-onchip, based on thin-film sensors, suitable for DNA treatments. In particular, the system performs on-chip DNA amplification and separation of double-strand DNA into single-strand DNA, combining a polydimethylsiloxane microfluidic network, thin-film electronic devices, and surface chemistry. Both the analytical procedures rely on the integration on the same glass substrate of thinfilm metal heaters and amorphous silicon temperature sensors to achieve a uniform temperature distribution (within ±1°C) in the heated area and a precise temperature control (within ±0.5°C). The DNA separation also counts on the binding between biotinylated dsDNA and a layer of streptavidin immobilized into a microfluidic channel through polymer-brushes-based layer. This approach results in a fast and low reagents consumption system. The tested DNA treatments can be applied for carrying out the on-chip systematic evolution of ligands by exponential enrichment process, a chemistry technique for the selection of aptamers.Index Terms-Amorphous silicon sensor, lab-on-chip (LoC), systematic evolution of ligands by exponential enrichment (SELEX).

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Section: B Dsdna Separation On Chipmentioning

confidence: 99%

Integrated Sensor System for DNA Amplification and Separation Based on Thin Film Technology

Costantini

Petrucci

Lovecchio

et al. 2018

IEEE Trans. Compon., Packag. Manufact. Technol.

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Microheater: material, design, fabrication, temperature control, and applications—a role in COVID-19

Jeroish

Bhuvaneshwari

Samsuri

et al. 2021

Biomed Microdevices

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Thermal control system based on thin film heaters and amorphous silicon diodes

Lovecchio

Petrucci

Caputo

et al. 2015

2015 6th International Workshop on Advances in Sensors and Interfaces (IWASI)

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In this paper we present a system able to perform thermal treatments on lab-on-chip devices fabricated on glass substrates. The system includes a thin film resistor acting as heater and thin film hydrogenated amorphous silicon diodes acting as temperature sensors. An electronic system controls the lab-on-chip temperature through a Proportional-IntegralDerivative algorithm. In particular, an electronic board infers the system temperature measuring the voltage across the amorphous silicon diodes and drives the heater to achieve the set-point temperature. Taking into account the 16-bit ADC resolution and the sensors sensitivity, which is around 3.6 mV/C, we estimate that our system is able to detect temperature variation as low as 3.5·10-3 C

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Accurate analog temperature control of a thin film microheater on glass substrate for lab-on-chip applications

Cited by 4 publications

References 6 publications

Integrated Sensor System for DNA Amplification and Separation Based on Thin Film Technology

Integrated Sensor System for DNA Amplification and Separation Based on Thin Film Technology

Microheater: material, design, fabrication, temperature control, and applications—a role in COVID-19

Thermal control system based on thin film heaters and amorphous silicon diodes

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