Accuracy, repeatability, and interplatform reproducibility of T<sub>1</sub> quantification methods used for DCE‐MRI: Results from a multicenter phantom study

Bane, Octavia; Hectors, Stefanie; Wagner, Mathilde; Arlinghaus, Lori R.; Aryal, Madhava; Cao, Yue; Chenevert, Thomas L.; Fennessy, Fiona M.; Huang, Wei; Hylton, Nola M.; Kalpathy–Cramer, Jayashree; Keenan, Kathryn E.; Malyarenko, Dariya I.; Mulkern, Robert V.; Newitt, David C.; Russek, Stephen E.; Stupic, Karl F.; Tudorica, Alina; Wilmes, Lisa J.; Yankeelov, Thomas E.; Yen, Yi Fei; Boss, Michael A.; Taouli, Bachir

doi:10.1002/mrm.26903

Cited by 81 publications

(116 citation statements)

References 48 publications

(80 reference statements)

Supporting

Mentioning

108

Contrasting

Unclassified

Order By: Relevance

“…Phantom quality control may ensure adequate precision and reproducibility in T 1 measurements, a prerequisite for performing quantitative DCE analysis. It also allows for the measurement of the contrast response of the employed DCE acquisition sequence across a range of T 1 relaxation rates observed in in vivo DCE studies and the stability of that contrast response over time and across system upgrades …”

Section: Precision Metrologymentioning

confidence: 99%

“…Often, each vendor and platform has preferred acquisition protocols. The T 1 values in clinics are influenced by B 1 field inhomogeneity, incomplete spoiling of transverse magnetization, and MR sequence used for the range of T 1 values to be measured . One of the QIBA recommendations is to standardize acquisition parameters to reduce sources of variability for DCE imaging, possibly at the expense of moderate protocol capabilities for some systems.…”

Section: Precision Metrologymentioning

confidence: 99%

“…One recommended QIBA DCE T 1 phantom contains vials of varying concentrations of nickel chloride solutions . Figure shows the phantom design that consists of two sets of spherical inserts.…”

Section: Precision Metrologymentioning

confidence: 99%

“…To mimic the coil loading of a patient, the phantom was filled with a 30‐mM sodium chloride (Sigma‐Aldrich, St. Louis, MO) solution. The scan protocol for T 1 measurement consists of acquiring coronal fast spoiled gradient echo sequences with variable flip angles (VFAs) of 30°, 25°, 20°, 15° 10°, 5°, and 2° to fully cover the range used for T 1 mapping in clinical studies . Test–retest reliability and T 1 accuracy evaluation using the QIBA DCE phantom should be considered for longitudinal studies.…”

Section: Precision Metrologymentioning

confidence: 99%

See 3 more Smart Citations

Quantitative imaging biomarkers alliance (QIBA) recommendations for improved precision of DWI and DCE‐MRI derived biomarkers in multicenter oncology trials

Shukla–Dave

Obuchowski

Chenevert

et al. 2018

Magnetic Resonance Imaging

Self Cite

270

232

View full text Add to dashboard Cite

Physiological properties of tumors can be measured both in vivo and noninvasively by diffusion‐weighted imaging and dynamic contrast‐enhanced magnetic resonance imaging. Although these techniques have been used for more than two decades to study tumor diffusion, perfusion, and/or permeability, the methods and studies on how to reduce measurement error and bias in the derived imaging metrics is still lacking in the literature. This is of paramount importance because the objective is to translate these quantitative imaging biomarkers (QIBs) into clinical trials, and ultimately in clinical practice. Standardization of the image acquisition using appropriate phantoms is the first step from a technical performance standpoint. The next step is to assess whether the imaging metrics have clinical value and meet the requirements for being a QIB as defined by the Radiological Society of North America's Quantitative Imaging Biomarkers Alliance (QIBA). The goal and mission of QIBA and the National Cancer Institute Quantitative Imaging Network (QIN) initiatives are to provide technical performance standards (QIBA profiles) and QIN tools for producing reliable QIBs for use in the clinical imaging community. Some of QIBA's development of quantitative diffusion‐weighted imaging and dynamic contrast‐enhanced QIB profiles has been hampered by the lack of literature for repeatability and reproducibility of the derived QIBs. The available research on this topic is scant and is not in sync with improvements or upgrades in MRI technology over the years. This review focuses on the need for QIBs in oncology applications and emphasizes the importance of the assessment of their reproducibility and repeatability. Level of Evidence: 5 Technical Efficacy Stage: 1 J. Magn. Reson. Imaging 2019;49:e101–e121.

show abstract

Section: Precision Metrologymentioning

confidence: 99%

Section: Precision Metrologymentioning

confidence: 99%

Section: Precision Metrologymentioning

confidence: 99%

Section: Precision Metrologymentioning

confidence: 99%

See 2 more Smart Citations

Quantitative imaging biomarkers alliance (QIBA) recommendations for improved precision of DWI and DCE‐MRI derived biomarkers in multicenter oncology trials

Shukla–Dave

Obuchowski

Chenevert

et al. 2018

Magnetic Resonance Imaging

Self Cite

270

232

View full text Add to dashboard Cite

show abstract

“…Parameter measurements should be repeatable, eg, by correcting for effects of nonlinear gradients on apparent diffusion coefficient (ADC) and velocity measurements, and isolating effects of magnetization transfer on T 1 measurements. In tandem, we should better emphasize reliability and reduced variability of images, across patients, technologists, scanners, and coils …”

Section: Better Define Mrmentioning

confidence: 99%

High‐Value MRI

Pipe

2018

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Determining the longitudinal accuracy and reproducibility of T₁ and T₂ in a 3T MRI scanner

Carr

Keenan

Rai

et al. 2021

J Applied Clin Med Phys

Self Cite

View full text Add to dashboard Cite

To determine baseline accuracy and reproducibility of T 1 and T 2 relaxation times over 12 months on a dedicated radiotherapy MRI scanner. Methods: An International Society of Magnetic Resonance in Medicine/National Institute of Standards and Technology (ISMRM/NIST) System Phantom was scanned monthly on a 3T MRI scanner for 1 year. T 1 was measured using inversion recovery (T 1 -IR) and variable flip angle (T 1 -VFA) sequences and T 2 was measured using a multi-echo spin echo (T 2 -SE) sequence. For each vial in the phantom, accuracy errors (%bias) were determined by the relative differences in measured T 1 and T 2 times compared to reference values. Reproducibility was measured by the coefficient of variation (CV) of T 1 and T 2 measurements across monthly scans. Accuracy and reproducibility were mainly assessed on vials with relaxation times expected to be in physiological ranges at 3T. Results: A strong linear correlation between measured and reference relaxation times was found for all sequences tested (R 2 > 0.997). Baseline bias (and CV[%]) for T 1 -IR, T 1 -VFA and T 2 -SE sequences were +2.0% (2.1), +6.5% (4.2), and +8.5% (1.9), respectively. Conclusions: The accuracy and reproducibility of T 1 and T 2 on the scanner were considered sufficient for the sequences tested. No longitudinal trends of variation were deduced, suggesting less frequent measurements are required following the establishment of baselines.

show abstract

Accuracy, repeatability, and interplatform reproducibility of T₁ quantification methods used for DCE‐MRI: Results from a multicenter phantom study

Cited by 81 publications

References 48 publications

Quantitative imaging biomarkers alliance (QIBA) recommendations for improved precision of DWI and DCE‐MRI derived biomarkers in multicenter oncology trials

Quantitative imaging biomarkers alliance (QIBA) recommendations for improved precision of DWI and DCE‐MRI derived biomarkers in multicenter oncology trials

High‐Value MRI

Determining the longitudinal accuracy and reproducibility of T₁ and T₂ in a 3T MRI scanner

Contact Info

Product

Resources

About

Accuracy, repeatability, and interplatform reproducibility of T1 quantification methods used for DCE‐MRI: Results from a multicenter phantom study

Cited by 81 publications

References 48 publications

Quantitative imaging biomarkers alliance (QIBA) recommendations for improved precision of DWI and DCE‐MRI derived biomarkers in multicenter oncology trials

Quantitative imaging biomarkers alliance (QIBA) recommendations for improved precision of DWI and DCE‐MRI derived biomarkers in multicenter oncology trials

High‐Value MRI

Determining the longitudinal accuracy and reproducibility of T1 and T2 in a 3T MRI scanner

Contact Info

Product

Resources

About

Accuracy, repeatability, and interplatform reproducibility of T₁ quantification methods used for DCE‐MRI: Results from a multicenter phantom study

Determining the longitudinal accuracy and reproducibility of T₁ and T₂ in a 3T MRI scanner