Accuracy of the triglyceride to high-density lipoprotein cholesterol ratio for prediction of the low-density lipoprotein phenotype B

Hanak, Viktor; Munoz, Julian; Teague, Joe; Stanley, Alfred W.H.; Bittner, Vera

doi:10.1016/j.amjcard.2004.03.069

Cited by 136 publications

(131 citation statements)

References 9 publications

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“…The associations between LDL size and other proxy measures (LDL-C/apoB, TC/HDL-C, and apoB/HDL-C ratios) were weaker. Various cut points for the TG/HDL-C molar ratio suggested to identify adults with the small, dense LDL phenotype (19,21,22 ) include 0.9, 1.33, and 1.7. In our pediatric population, the sensitivities and specificities of these cut points were 85.9% and 78.2%, 76.1% and 93.5%, and 67.3% and 97.6%, respectively.…”

Section: Resultsmentioning

confidence: 99%

Distribution of LDL Particle Size in a Population-Based Sample of Children and Adolescents and Relationship with Other Cardiovascular Risk Factors

Stan¹,

Lévy²,

Delvin³

et al. 2005

Clinical Chemistry

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Background: Smaller, denser LDL particles are associated with an increased risk for cardiovascular diseases (CVD). In youths, data on the distribution of LDL particle size and on its association with other CVD risk factors are limited. Methods: We determined LDL peak particle size by nondenaturing 2%-16% gradient gel electrophoresis in a representative sample of 2249 youths 9, 13, and 16 years of age who participated in a school-based survey conducted in 1999 in the province of Quebec, Canada. Standardized clinical measurements and fasting plasma lipid, glucose, and insulin concentrations were available. Results: The LDL peak particle size distribution was gaussian. The 5th, 50th (median), and 95th percentiles by age and sex were 255.5-258.6, 262.1-263.2, and 268.1-269.5 Å, respectively. The prevalence of the small, dense LDL phenotype (LDL peak particle size <255 Å) was 10% in participants with insulin resistance syndrome (IRS), in contrast to 1% in those without IRS. In a multiple regression analysis, the association of LDL size with other CVD risk factors [apolipoprotein B, HDLcholesterol (HDL-C), triglyceride (TG), and insulin concentrations, and body mass index] was strongest with TG and HDL-C concentrations: a 1 SD increase in log e -transformed TG concentration was associated with

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Section: Resultsmentioning

confidence: 99%

Distribution of LDL Particle Size in a Population-Based Sample of Children and Adolescents and Relationship with Other Cardiovascular Risk Factors

Stan¹,

Lévy²,

Delvin³

et al. 2005

Clinical Chemistry

View full text Add to dashboard Cite

show abstract

“…It is linked to IR in whites 233,234 (but not in blacks) and to small, dense LDL particles and higher LDL particle numbers. 233,235 The link between IR and the ratio of triglycerides to HDL-C is already apparent in youth. 236 In recent years, case-control and prospective studies have linked the ratio of triglycerides to HDL-C to CVD incidence, outcomes, and all-cause mortality, [237][238][239][240][241][242] with improved predictive power in some studies compared with LDL-C or non-HDL-C. 238,239,242 …”

Section: Ratio Of Triglycerides To Hdl-cmentioning

confidence: 99%