Accuracy of the Medication Adherence Report Scale (MARS-5) as a Quantitative Measure of Adherence to Inhalation Medication in Patients With COPD

Tommelein, Eline; Mehuys, Els; Tongelen, Inge Van; Brusselle, Guy; Boussery, Koen

doi:10.1177/1060028014522982

Cited by 84 publications

(80 citation statements)

References 32 publications

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“…However, our results can only be interpreted in the context of epilepsy treatment, because the MARS-5 score has been found ineffective to accurately reflect medication adherence in patients with other diseases [18,19]. Moreover, after controlling for demographic parameters, we found that seizure severity and serum drug level can correlate well with the MARS-5 score.…”

Section: Discussionmentioning

confidence: 46%

“…Therefore, there is the need for a reliable self-reporting instrument (e.g., the Medication Adherence Report Scale, MARS-5) which can provide relatively accurate information on AED adherence. Previous studies suggest that the MARS-5 failed to distinguish well-adherent and nonadherent patients with chronic obstructive pulmonary disease [18] and hypertension [19]. However, such poor efficacy may not occur in people with epilepsy because of different clinical characteristics.…”

Section: Introductionmentioning

confidence: 97%

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Correlation between adherence to antiepileptic drugs and quality of life in patients with epilepsy: A longitudinal study

Lin

Chen

Pakpour

2016

Epilepsy & Behavior

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Section: Discussionmentioning

confidence: 46%

Section: Introductionmentioning

confidence: 97%

Correlation between adherence to antiepileptic drugs and quality of life in patients with epilepsy: A longitudinal study

Lin

Chen

Pakpour

2016

Epilepsy & Behavior

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“…Similarly, we found that the psychometric evaluation of the MARS-5 has only been done on populations without stroke using classical test theory. 21Y23 Although some studies have argued whether the MARS-5 can accurately measure drug adherence, 24,25 other studies have found that the MARS-5 can accurately measure medication adherence. 26,27 In fact, Lin et al 28 concluded that the unique characteristics of different diseases may contribute to different findings regarding the accuracy of the MARS-5.…”

mentioning

confidence: 99%

Validation of the 5-Item Medication Adherence Report Scale in Older Stroke Patients in Iran

Lin

Ou²,

Nikoobakht

et al. 2018

J Cardiovasc Nurs

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Background: There is a lack of feasible and validated measures to self-assess medication adherence for older patients with stroke. In addition, the potential determinants of medication adherence for older patients with stroke remain unclear. Objectives: The aims of this study were to (1) examine the psychometric properties of a 5-item questionnaire on medication adherence, specifically the 5-item Medication Adherence Report Scale (MARS-5), and (2) explore the determinants of medication adherence. Methods: Stroke patients older than 65 years (N = 523) filled out the MARS-5 and the Hospital Anxiety and Depression Scale. The medication possession rate (MPR) was calculated to measure the objective medication adherence. Several clinical characteristics (stroke types, blood pressure, comorbidity, HbA1c, quantity of prescribed drugs, fasting blood glucose, and total cholesterol) and background information were collected. We used Rasch analysis with a differential item functioning test to examine psychometric properties. Results: All 5 items in the MARS-5 fit in the same construct (ie, medication adherence), no differential item functioning items were displayed in the MARS-5 across gender, and the MARS-5 total score was strongly correlated with the MPR (r = 0.7). Multiple regression models showed that the MARS-5 and the MPR shared several similar determinants. In addition, the variance of the MARS-5 (R 2 = 0.567) was more than that of the MPR (R 2 = 0.300). Conclusions: The MARS-5 is a feasible and

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“…Research techniques to address adherence with inhaled medication include canister weighing and electronic monitoring of inhaler actuation. Self-reporting is a simple and easy way to assess adherence and is useful in identifying patients' reasons for non-adherence [121], although the accuracy of this method has been questioned [122]. Numbers of filled prescriptions are used as an indicator of adherence/persistence, but again may not reflect medications taken.…”

Section: Remaining Questions and Future Researchmentioning

confidence: 99%

Assessing the clinical value of fast onset and sustained duration of action of long-acting bronchodilators for COPD

Cazzola

Beeh

Price

et al. 2015

Pulmonary Pharmacology & Therapeutics

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The long-acting inhaled bronchodilators available for use in chronic obstructive pulmonary disease (COPD) vary in their pharmacological class (β2-adrenergic agonist or antimuscarinic/anticholinergic, alone or combined), durations of action and speed of onset of bronchodilator effect. In the early stages of development of a maintenance bronchodilator, the goals are to identify a molecule with the theoretically 'ideal' profile of fast onset and prolonged duration of action in comparison with existing agents, while minimizing non-specific activity at organs outside the lungs. The move towards increasing duration of bronchodilator action is generally paralleled by improved effects on clinical outcomes, and the advent of more potent agents seems likely to provide an opportunity to reduce overreliance on the use of inhaled corticosteroids in treating COPD. In terms of onset of action, an immediately perceived benefit in reducing dyspnea, although not definitively demonstrated, might prove useful in increasing adherence, which is very poor among patients with COPD. Once-daily administration may also be helpful in this respect. Shared decision-making between patient and physician in the choice of treatment is important in optimizing adherence and, thus, treatment effectiveness.

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Accuracy of the Medication Adherence Report Scale (MARS-5) as a Quantitative Measure of Adherence to Inhalation Medication in Patients With COPD

Abstract: Self-reported adherence measured by MARS-5 is inaccurate in identifying nonadherence to inhalation medication in patients with COPD.

Cited by 84 publications

References 32 publications

Correlation between adherence to antiepileptic drugs and quality of life in patients with epilepsy: A longitudinal study

Correlation between adherence to antiepileptic drugs and quality of life in patients with epilepsy: A longitudinal study

Validation of the 5-Item Medication Adherence Report Scale in Older Stroke Patients in Iran

Assessing the clinical value of fast onset and sustained duration of action of long-acting bronchodilators for COPD

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