Background: The body has a thermoregulation setting where when it gets hot, the body responds by dilating blood vessels or vasodilation, otherwise it gets a cold response, which causes narrowing of blood vessels or vasoconstriction. The thermal conditioning system is a system that can influence the baby in terms of its thermal quality. So that the baby can feel a comfortable environment or not. Skin temperature is a fundamental factor in heat exchange between the body and its environment. Objective: The purpose of this study was to analyze the effect of thermal exposure to carbon fiber filaments in the thermoreceptor area on the physiological response of hypothermic baby rabbits to changes in body temperature, to analyze the time needed for physiological adaptation of the body’s skin to occur and to analyze the response of the thermoreceptor area on the head, neck, chest, arms, wrists, soles of the feet, to changes in each local area of the body. Methods: The research method used is pure experimental or laboratory experimental, with a post-test only control group design approach that uses experimental animals as experimental objects. The treatment in this study was using baby rabbits. The Sampling of test animals was carried out using simple random sampling. Statistical analysis was performed using IBM SPSS Statistics version 20. The confidence level was set at 95% by one way ANOVA test. Results: The results showed that the response of the thermoreceptor area to thermal exposure on the neck was the highest with an average of 39.77’. Conclusion: Based on the results of the analysis, it was concluded that there was an effect of thermal exposure to carbon fiber filaments in the thermoreceptor area on the physiological response of hypothermic baby rabbit models to changes in body temperature.