Accuracy of the automated assessment of left ventricular function with gated perfusion SPECT in the presence of perfusion defects and left ventricular dysfunction: Correlation with equilibrium radionuclide ventriculography and echocardiography

Chua, Terrance; Yin, Lee Chung; Thiang, Tan Hwee; Choo, Tai Bee; Ping, Ding; Leng, Lim Yean

doi:10.1067/mnc.2000.105279

Cited by 64 publications

(56 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several groups have compared the quantitative results from the QGS software with similar results from other modalities. Generally in mixed datasets, the concordance with regard to the LVEF is good for contrast ventriculography and ultrasound techniques [6][7][8][9]. Similarly, the concordance with regard to wall thickening is quite good [12].…”

Section: Discussionmentioning

confidence: 99%

“…Some studies report on mean count activity. Chua et al [7] presented a mean count activity of 19.9% ± 10.5 % of maximal myocardial count activity. Hashimoto et al [20] reported that myocardium with a per cent peak count of 40% or less has very low probability of myocardial viability.…”

Section: Prototypesmentioning

confidence: 96%

“…In which quantitative assessment of end-diastolic and end-systolic perfusion, wall motion and wall thickening using the 20-segment bull's eye representation of the QGS model [ figure 2], as well as estimates for end-diastolic (EDV) and end-systolic (ESV) ventricular volume and derived stroke volume and LVEF is incorporated. The underlying algorithms have been reviewed in literature [2][3][4][5][6][7][8][9][10][11][12][13]17]. The software algorithm implementation is the same in the different camera systems.…”

Section: Gated Spect Protocolmentioning

confidence: 99%

“…Based on an earlier analysis [7,20], it was concluded that segmental uptakes below 40% in the QGS 20-segment endsystolic perfusion quantification corresponded best with severe perfusion defects. The extent of the perfusion defect is the summation of all segments with a severe perfusion defect.…”

Section: Criteria For Defect Size (Extent) and Severitymentioning

confidence: 99%

“…With regard to the validation of the Cedars-Sinai's Quantitative SPECT (QGS) software, several requirements have already been met. The algorithm and its basic validation have already been described [2][3][4][5][6][7][8][9][10][11][12][13][14][15]. However, one particular issue is still not fully solved: reproducibility of the quantitative assessment of regional functional parameters in the presence of severe major defects or artifacts.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Evaluation of the Quantitative Gated SPECT (QGS) software program in the presence of large perfusion defects

America

Bax

Dibbets‐Schneider

et al. 2005

Int J Cardiovasc Imaging

View full text Add to dashboard Cite

Objectives: To evaluate the reproducibility and operator dependence for the quantitative regional left ventricular functional parameters (LVFP) assessed by Cedars-Sinai's Quantitative automated gated SPECT (QGS) software. Methods: The QGS algorithm was reviewed in detail and potential operator dependencies were defined. Series of prototypes were selected, consisting of a) normal perfusion, b) perfusion defects in all perfusion regions, c) perfusion studies of patients with angiographic confirmed normal coronary arteries, proximal ( >70% stenoses) single and multiple vessel disease, and d) spurious activity in close proximity. While defining and re-orienting the volume containing the left ventricle, the operator adjusted 8 variables/ degrees of freedom (DF). The software was used without further operator interventions. Results were expressed as a coefficient of variation (COV). Separate COV were calculated per distinct DF. A segment was considered not robust when the COV did exceed 20% in a single DF, 15% in at least 2 DF, or 10% in at least 3 DF. Results: Regional left ventricular EF and volumes showed excellent reproducibility. Normal perfusion and the vessel disease prototypes showed an excellent COV (for all re-orientation steps [33/prototype]) mostly below 5% for LVFP. However, regional wall motion and thickening became less reliable in the presence of large perfusion defects or artifacts. Conclusions: Quantitative estimates for regional left ventricular functional data show excellent reproducibility using automated gated SPECT. However, there may be substantial operator dependency in the presence of large defects or spurious activity in close proximity.

show abstract