Accuracy of splitting unscored valdecoxib tablets

Boggie, Daniel T.; DeLattre, Melissa L.; Schaefer, Monica; Morreale, Anthony P.; Plowman, Brian K.

doi:10.1093/ajhp/61.14.1482

Cited by 14 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2003), while others have reported the percentage of tablet fragments deviating more than 10% or 20% from theoretical weight (Mcdevitt et al. 1998), mean deviations (Boggie et al. 2004) or maximum losses (Biron et al.…”

Section: Discussionmentioning

confidence: 97%

“…Although some literature is available on this topic, authors have reported their findings in different ways, making comparison difficult. Some have reported deviation ranges (Cook et al 2003), while others have reported the percentage of tablet fragments deviating more than 10% or 20% from theoretical weight (Mcdevitt et al 1998), mean deviations (Boggie et al 2004) or maximum losses (Biron et al 1999). Some studies focused on only one splitting method or type of drug (Mcdevitt et al 1998, Biron et al 1999, while others compared different methods (Peek et al 2002, Teng et al 2002, Cook et al 2003 or different tablets (Polli et al 2003, Boggie et al 2004, Kayumba et al 2006.…”

Section: Effects Of Tablet-splittingmentioning

confidence: 99%

“…2004), kitchen knives (Cook et al. 2003) and splitting by hand (Babington 1997, Boggie et al. 2004).…”

Section: Introductionmentioning

confidence: 99%

“…There has been previous research on the impact of tabletsplitting on dose accuracy. Reports published so far have concerned splitting devices (Peek et al 2002, Cook et al 2003, Boggie et al 2004, kitchen knives (Cook et al 2003) and splitting by hand (Babington 1997, Boggie et al 2004). However, no researchers have compared the weight unifor-mity of all splitting methods used in nursing homes.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Tablet-splitting: a common yet not so innocent practice

Verrue

Mehuys

Boussery

et al. 2010

Journal of Advanced Nursing

108

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Effects Of Tablet-splittingmentioning

confidence: 99%

“…2004), kitchen knives (Cook et al. 2003) and splitting by hand (Babington 1997, Boggie et al. 2004).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Tablet-splitting: a common yet not so innocent practice

Verrue

Mehuys

Boussery

et al. 2010

Journal of Advanced Nursing

108

View full text Add to dashboard Cite

show abstract

“…However, some studies revealed that splitting may result in the administration of an inaccurate dose, which can be of significant risk, especially if the split tablet formulation has a narrow therapeutic index [4,5]. Tablets are either hand-split or split using a variety of tablet splitters for scored or unscored tablets [6,7,8,9]. With these devices (which are easy to use), the tablets are cut into halves.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Certain Pharmaceutical Quality Attributes of Lisinopril Split Tablets

et al. 2016

View full text Add to dashboard Cite

Tablet splitting is an accepted practice for the administration of drugs for a variety of reasons, including dose adjustment, ease of swallowing and cost savings. The purpose of this study was to evaluate the physical properties of lisinopril tablets as a result of splitting the tablets either by hand or with a splitting device. The impact of the splitting technique of lisinopril (Zestril® tablets, 20 mg) on certain physical parameters such as weight variation, friability, disintegration, dissolution and drug content were studied. Splitting the tablets either by hand or with a splitter resulted in a minute but statistically significant average weight loss of <0.25% of the tablet to the surrounding environment. The variability in the weight of the hand-split tablet halves was more pronounced (37 out of 40 tablet halves varied by more than 10% from the mean weight) than when using the tablet splitter (3 out of 40 tablet halves). The dissolution and drug content of the hand-split tablets were therefore affected because of weight differences. However, the pharmacopoeia requirements for friability and disintegration time were met. Hand splitting of tablets can result in an inaccurate dose and may present clinical safety issues, especially for drugs with a narrow therapeutic window in which large fluctuations in drug concentrations are undesirable. It is recommended to use tablets with the exact desired dose, but if this is not an option, then a tablet splitter could be used.

show abstract

Does splitting a tablet obtain an accurate dose? A systematic review and meta‐ analysis

Chaudhri

Kearney

Tanna

et al. 2022

Pharmacy Practice and Res

View full text Add to dashboard Cite

Background Tablet splitting is a widely prevalent practice resulting from the need to alter doses into two or more parts and optimise medicine in individual patients. If a tablet is split unequally problems may arise. Aim The aim of the study was to summarise the literature measuring the effect of tablet splitting on dose accuracy. Method MEDLINE, EMBASE, CINAHL and Cochrane were searched and studies published prior to January 2020 investigating the effect of splitting tablets on dose accuracy were included. Studies investigating any drug, where the tablet was split, were potentially eligible. Two independent reviewers conducted the screening and extracted the data. Meta‐analyses assessing the effect of tablet splitting on dose accuracy were performed. (Study registration: PROSPERO CRD42018106252). Results Of 25 included studies, 16 examined the effect of tablet splitting on weight of the tablet, one on drug concentration and eight examined both. Meta‐analysis found small variation between split tablets (0.87% weight variation, 95% confidence interval 0.63%–1.11% and 0.24% drug content variation, 95% confidence interval 0.06%–0.43%). There was some inconsistency across trial results for weight but not for drug content variation (I2 50% and I2 1%, respectively). Splitting method and tablet characteristics were predictors of accuracy. Conclusion Although tablet splitting may influence dose accuracy, this analysis suggests that the weight and drug content variation is minimal, regardless of method and tablet characteristics. Additional studies, such as those examining drug plasma concentrations and effect on patient health outcomes for example blood pressure and cholesterol levels, are needed to better understand the role of tablet splitting on dose accuracy.

show abstract

Accuracy of splitting unscored valdecoxib tablets

Cited by 14 publications

References 0 publications

Tablet-splitting: a common yet not so innocent practice

Tablet-splitting: a common yet not so innocent practice

Evaluation of Certain Pharmaceutical Quality Attributes of Lisinopril Split Tablets

Does splitting a tablet obtain an accurate dose? A systematic review and meta‐ analysis

Contact Info

Product

Resources

About