Accuracy of sonographic vascular features in differentiating different causes of cervical lymphadenopathy

Ying, Michael; Ahuja, Anil T.; Brook, Fiona

doi:10.1016/j.ultrasmedbio.2003.12.009

Cited by 73 publications

(65 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Among these criteria, nodal size and depiction of necrosis are the most important sonographic criteria (16). As technology has developed and with the introduction of power Doppler sonography, it has become possible to evaluate the pattern of intranodal vessels and measure blood flow velocity and vascular resistance with spectral Doppler gates (15,17). Kagawa and colleagues (18) have reported that blood flow signals become scattered and that the scattering index increases as the metastatic lymph node size increases.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Sonographic Imaging to Diagnose Lymph Node Metastasis: Importance of Blood Vessel Volume and Density

Mori

Kodama

et al. 2013

Cancer Research

View full text Add to dashboard Cite

Lymph node size is an important variable in ultrasound diagnosis of lymph node metastasis. However, the size criterion often leads to oversight of tumor-positive lymph nodes within the range of "normal" size, such that more accurate diagnostic criteria for lymph node metastasis are required. In this study, we show how diagnosis of lymph node metastasis can be improved by evaluating changes in blood vessel volume and density using a novel contrast-enhanced high-frequency ultrasound (CE-HFUS) system with Sonazoid. An MRL/MpJ-lpr/lpr (MRL/lpr) mouse model of lymph node metastasis was used in which lymph nodes are similar in size to humans. Metastasis via lymphatic vessels to proper axillary lymph nodes (proper ALN) was induced by injection of tumor cells into the subiliac lymph nodes. Within 21 days of injection, significant increases in blood vessel volume and density, but no increases in the size of the proper ALNs, were observed. The increase in blood vessel density was confirmed with immunohistochemical analysis and was positively related to tumor cell proliferation as measured using bioluminescence imaging. Together, our results showed that alterations in blood vessel volume and density precede alterations in lymph node size in the early stages of lymph node metastasis. Detection of these changes by ultrasonography may offer new criteria for early diagnosis of lymph node metastasis. Cancer Res; 73(7); 2082-92. Ó2013 AACR.

show abstract

Section: Introductionmentioning

confidence: 99%

Enhanced Sonographic Imaging to Diagnose Lymph Node Metastasis: Importance of Blood Vessel Volume and Density

Mori

Kodama

et al. 2013

Cancer Research

View full text Add to dashboard Cite

show abstract

“…4 Ultrasound can be the tool to diagnose it well than physical exam, FNA or biopsy are gold standard to diagnose it, CT scan is useful to diagnose deep adenopathies. 1,4 Early diagnosis and treatment with Chemotherapy can cure HL; however, our patient died because he came severely sick and at an advanced stage. We have to sensitize our community that if there is a lymph node appearing on their body, they must consult a doctor early to ensure a good result.…”

Section: Resultsmentioning

confidence: 99%

Difficult airway post multiple peripheral lymphadenopathy (pla): case report

Manirafasha¹,

Gandhi²,

Pousson³

et al. 2017

IJFCM

View full text Add to dashboard Cite

CaseA 22-year-old male consulting Emergency department for voice changes, cough for 1 week, neck swelling extending to the both ears lasting for 4 weeks, peri -orbital swelling, and swelling in both groins ( Figure 1). On arrival, he was in respiratory distress, oxygen saturation: 87%, unable to pronounce some letters; as emergency management, he was given oxygen 5L/ min with non retreater mask and saturation: 92-95%. Physical examinationThe patient had multiple huge adenopathies localized on cervical region, subclavical region, both axillar, and on both groins. Bed site Ultrasound findings: multiple lymph nodes of neck and para-auricular, cervical, axillar, and inguinal regions. The biggest measuring 3-5 cm. He also had huge ascitis, bilateral pleural effusion, and small pericardial effusion. Initial laboratory results were showing mild elevated white blood cell (24.15), with normal differentiation Hemoglobin of 8.3g/dl; renal, liver function test, and electrolytes were normal. The following are bed site ultrasound images (Figures 2-7). Based on history, physical exam and Ultrasound images, we can conclude that swelling is lymph nodes and not anything else. Our differential diagnoses were Hodgikin lymphoma. To rule out TB adenitis, the internal medicine consultant requested a fine needle aspiration (FNA), which was none conclusive, and the pathologist suggested doing an open biopsy. The results of open biopsy showed: HL Hodgkin lymphoma (Nodular sclerosis type). Nodular sclerosis Hodgkin's disease accounts for 80% of all Hodgkin's disease. AbstractPeripheral lymphadenopathy is a condition found frequently in tropical regions, which is sometimes due to a local or systemic, benign, infectious, or underlying malignancy. According to research, 75% are localized with 50% seen on head and neck.

show abstract

“…Using less detailed classifications of vascularization, other authors have also reported lymphomas displaying the benign pattern described as ''hilar vascularity.'' However, the frequency of this pattern varied widely in these reports, ranging from 28.5% in the series examined by Ying et al [13] to over 90% in those analyzed by Giovagnorio et al (97% of the non-Hodgkin lymphomas, 94% of the Hodgkin lymphomas) [15].…”

Section: Discussionmentioning

confidence: 95%

Vascular patterns in superficial lymphomatous lymph nodes: A detailed sonographic analysis

Białek

Jakubowski

Szczepanik

et al. 2007

Journal of Ultrasound

View full text Add to dashboard Cite

KEYWORDSLymph nodes; Lymphoma; Ultrasound; Power Doppler; Vessel pattern.Abstract Purpose: To identify the vascular patterns found in superficial lymph nodes with histologically confirmed lymphomatous involvement and to determine their value in the sonographic diagnosis of lymphadenopathy. Methods and materials: The study involved the prospective classification of vascular patterns observed during power Doppler and/or color Doppler studies of superficial lymph nodes scheduled for resection. Forty patients (27 men and 13 women, aged 22e84 years; mean age: 58 years) with pathologically proven lymphoma were selected for this study (26 cervical, 13 axillary and 1 inguinal). Results: A longitudinal vessel with or without branches (pattern I) was found in 14 lymphomatous nodes. Six contained short vessel segments distributed in the hilum area or centrally (pattern II), five had multiple vessels, partially branching, entering the node in a few rows from its longitudinal side (pattern III), seven presented multiple vessels that branched irregularly or chaotically with avascular areas (pattern IV), and eight had a peripheral vessel distribution (pattern V). Therefore, 50% of the lymphomatous nodes had vascular patterns regarded as characteristic of reactive lymph nodes (patterns I and II), and 37.5% had patterns normally described in lymph nodes with metastatic involvement (patterns IV and V); other lymphomatous lymph nodes had ambiguous vascular patterns that have not been previously classified (pattern III). Conclusion: The angioarchitecture of superficial lymphomatous lymph nodes varies widely and is difficult to classify. It may resemble that reported in normal or reactive lymph nodes or patterns that are associated with metastases. The finding of a normal or benign vascular pattern in a lymph node with suspected lymphomatous involvement does not eliminate the need for a diagnostic biopsy. Sommario Scopo: Valutazione dei possibili pattern vascolari dei linfonodi superficiali interessati da linfoma confermato da esame istologico allo scopo di ottenere un elemento aggiuntivo nella diagnosi differenziale ecografica tra patologie interessanti i linfonodi. Materiali e metodi: È stata effettuata una classificazione ecografica prospettica di pattern vascolari color e power Doppler di 55 linfonodi superficiali programmati per resezione. Sono stati selezionati per questo studio 40 pazienti con diagnosi istologica di linfoma (26 linfonodi cervicali, 13 ascellari e 1 inguinale). Il gruppo di pazienti studiato era comprensivo di 27 uomini e 13 donne, età 22e84 anni (età media: 58 anni). Risultati: È stato trovato un vaso lungitudinale con o senza ramificazioni (pattern I) in 14 linfoadenopatie; piccoli segmenti vascolari distribuiti nell'area dell'ilo o nella zona centrale del linfonodo (pattern II) in 6 linfoadenopatie. Vasi multipli, parzialmente ramificati, che entrano nel linfonodo in alcune file dal lato longitudinale (pattern III) sono stati riscontrati in 5 linfonodi mentre vasi multipli che si ramificano irregolarmente o...

show abstract

Accuracy of sonographic vascular features in differentiating different causes of cervical lymphadenopathy

Cited by 73 publications

References 23 publications

Enhanced Sonographic Imaging to Diagnose Lymph Node Metastasis: Importance of Blood Vessel Volume and Density

Enhanced Sonographic Imaging to Diagnose Lymph Node Metastasis: Importance of Blood Vessel Volume and Density

Difficult airway post multiple peripheral lymphadenopathy (pla): case report

Vascular patterns in superficial lymphomatous lymph nodes: A detailed sonographic analysis

Contact Info

Product

Resources

About