Accuracy of SOFA, qSOFA, and SIRS scores for mortality in cancer patients admitted to an intensive care unit with suspected infection

Costa, Ramon Teixeira; Nassar, Antônio Paulo; Caruso, Pedro

doi:10.1016/j.jcrc.2017.12.024

Cited by 38 publications

(52 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Sequential organ failure assessment (SOFA) score and American Society of Anesthesiologists (ASA) score have been shown to be good predictors of patient mortality [ 19 , 20 , 21 ]. Our results showed differences in these scores between adequate and inadequate nutrition groups.…”

Section: Discussionmentioning

confidence: 99%

Association of Inadequate Caloric Supplementation with 30-Day Mortality in Critically Ill Postoperative Patients with High Modified NUTRIC Score

et al. 2018

View full text Add to dashboard Cite

Modified NUTRIC (mNUTRIC) score is a useful assessment tool to determine the risk of malnutrition in patients on mechanical ventilation (MV). We identified associations between postoperative calorie adequacy, 30-day mortality, and surgical outcomes in patients with high mNUTRIC scores. Medical records of 272 patients in the intensive care unit who required MV support for >24 h after emergency gastro-intestinal (GI) surgery between January 2007 and December 2017 were reviewed. Calorie adequacy in percentage (Calorie intake in 5 days ÷ Calorie requirement for 5 days × 100) was assessed in patients with high (5–9) and low (0–4) mNUTRIC scores. In the high mNUTRIC score group, patients with inadequate calorie supplementation (calorie adequacy <70%) had higher 30-day mortality than those with adequate supplementation (31.5% vs. 11.1%; p = 0.010); this was not observed in patients with low mNUTRIC scores. This result was also confirmed through Kaplan–Meier survival curve (p = 0.022). Inadequate calorie supplementation in the high mNUTRIC score group was not associated with Intra-abdominal infection (p = 1.000), pulmonary complication (p = 0.695), wound complication (p = 0.407), postoperative leakage (p = 1.000), or infections (p = 0.847). Inadequate calorie supplementation after GI surgery was associated with higher 30-day mortality in patients with high mNUTRIC scores. Therefore, adequate calorie supplementation could contribute to improved survival of critically ill postoperative patients with high risk of malnutrition.

show abstract

Section: Discussionmentioning

confidence: 99%

Association of Inadequate Caloric Supplementation with 30-Day Mortality in Critically Ill Postoperative Patients with High Modified NUTRIC Score

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Due to its predictive value and its attractive simple design several other studies have examined the predictive validity of qSOFA in ICU patients. 19,[23][24][25][26][27][28][29][30][31][32][33] The prognostic value of qSOFA in VOPs with sepsis, a population more likely to have poor prognosis compared to the populations in previous studies, is still unknown. It would be of great help when qSOFA, an easy and readily available bedside tool, turns out to be accurate enough for prognostication in these patients, since a quick and reliable prognostic tool is desired for them.…”

mentioning

confidence: 99%

Performance of the quick SOFA in very old ICU patients admitted with sepsis

Haas

Termorshuizen

Lange

et al. 2020

Acta Anaesthesiol Scand

View full text Add to dashboard Cite

Sepsis is a worldwide major healthcare problem, 1-3 responsible for significant morbidity, mortality, and resource utilization, including a substantial number of intensive care unit (ICU) admissions. 4,5 In the Western population, older patients are responsible for the majority of all episodes of sepsis. 6 As a consequence of the aging of the Western population, it is expected that in the upcoming decades more very elderly patients (≥80 years old) will be admitted to the ICU (very old intensive care

show abstract

“…Our observation that, at infection onset, SOFA was �2 in 100% of decedents and also in 99% of survivors, which was similarly reported in the sepsis-3 validation study [9] (98% and 90% respectively), revealed SOFA with the threshold of 2 to yield poor guidance as prognostic criterion in infected ICU patients. High sensitivity for in-hospital mortality of SOFA�2 at the expense of specificity was reported before [21,31]. Evaluated by risk ratios and correlation coefficients, SIRS�2 captured a similar risk for in-hospital mortality compared to SOFA_change�2 in infected patients.…”

Section: Associations Of Sepsis Criteria With In-hospital Mortalitymentioning

confidence: 71%

“…In very good agreement with sepsis-3 validation study, we observed moderate discrimination capacity of SOFA applications for in-hospital mortality in infected patients (AUROC for SOFA and SOFA_change respectively: 0.75 and 0.70 in our data while 0.74 and 0.70 in sepsis-3 [9]) that was higher than SIRS' AUROC for in-hospital mortality. Further studies in the ICU setting replicating this evaluation approach also reported comparable results [29,31,32,37]. However, the use of AUROC for the assessment of risk prediction in general [57] and for sepsis-3 validation in particular [17,58] was criticized.…”

Section: Associations Of Sepsis Criteria With In-hospital Mortalitymentioning

confidence: 88%

“…Sensitivity analysis. For sensitivity analyses, examination was limited to the day of ICU admission for two reasons: It entailed timely fixation for comparison between infected and non-infected patients, and major studies examining sepsis-3 in the ICU limited observation to the 24 hours after admission [29][30][31][32][33] (for details see S1 Appendix section C).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of different consensus definition criteria on sepsis diagnosis in a cohort of critically ill patients—Insights from a new mathematical probabilistic approach to mortality-based validation of sepsis criteria

et al. 2020

View full text Add to dashboard Cite

Background Sepsis-3 definition uses SOFA score to discriminate sepsis from uncomplicated infection, replacing SIRS criteria that were criticized for being inaccurate. Eligibility of sepsis-3 criteria for sepsis diagnosis and the applied validation methodology using mortality as endpoint are topic of ongoing debate. We assessed the impact of different criteria on sepsis diagnosis in our ICU and devised a mathematical approach for mortality-based validation of sepsis criteria. As infectious status is often unclear at clinical deterioration, we integrated non-infected patients into analysis. Methods Suspected infection, SOFA and SIRS were captured for an ICU cohort of a university center over one year. For raw scores (SIRS/SOFA) and sepsis criteria (SIRS�2/SOFA�2/ SOFA_change�2) frequencies and associations with in-hospital mortality were assessed. Using a mathematical approach, we estimated the correlation between sepsis and in-hospital mortality serving as reference for evaluation of observed mortality correlations of sepsis criteria. Results Of 791 patients, 369 (47%) were infected and 422 (53%) non-infected, with an in-hospital mortality of 39% and 15%. SIRS�2 indicated sepsis in 90% of infected patients, SOFA�2 in 99% and SOFA_change�2 in 77%. In non-infected patients, SIRS, SOFA and SOFA_ change were �2 in 78%, 88% and 58%. In AUROC analyses neither SOFA nor SIRS

show abstract

Accuracy of SOFA, qSOFA, and SIRS scores for mortality in cancer patients admitted to an intensive care unit with suspected infection

Cited by 38 publications

References 27 publications

Association of Inadequate Caloric Supplementation with 30-Day Mortality in Critically Ill Postoperative Patients with High Modified NUTRIC Score

Association of Inadequate Caloric Supplementation with 30-Day Mortality in Critically Ill Postoperative Patients with High Modified NUTRIC Score

Performance of the quick SOFA in very old ICU patients admitted with sepsis

Impact of different consensus definition criteria on sepsis diagnosis in a cohort of critically ill patients—Insights from a new mathematical probabilistic approach to mortality-based validation of sepsis criteria

Contact Info

Product

Resources

About