Objectives
In the contemporary intensive care unit (ICU), mechanically ventilated patients may not have arterial blood gas (ABG) measurements available at relevant timepoints. Severity criteria often depend on ABG results. Retrospective studies suggest that non-linear imputation of PaO2/FIO2 from SpO2/FIO2 is accurate, but this has not been established prospectively among mechanically ventilated ICU patients. The objective was to validate the superiority of non-linear imputation of PaO2/FIO2 among mechanically ventilated patients and understand what factors influence the accuracy of imputation.
Design
Simultaneous SpO2, oximeter characteristics, receipt of vasopressors, and skin pigmentation were recorded at the time of a clinical ABG. ARDS criteria were recorded. For each imputation method, we calculated both imputation error and the area under the curve (AUC) for patients meeting criteria for ARDS (PaO2/FIO2≤300) and moderate-severe ARDS (PaO2/FIO2≤150).
Setting
Nine hospitals within the Prevention and Early Treatment of Acute Lung Injury network.
Patients
We prospectively enrolled 703 mechanically ventilated patients admitted to the emergency departments or ICUs of participating study hospitals.
Interventions
None.
Measurements and Main Results
We studied 1034 ABGs from 703 patients; 650 ABGs were associated with SpO2≤96%. Non-linear imputation had consistently lower error than other techniques. Among all patients, non-linear had a lower error (p<0.001) and higher (p<0.001) AUC (0.87; 95% CI 0.85–0.90) for PaO2/FIO2 ≤300 than linear/log-linear (0.80; 95%CI 0.76–0.83) imputation. All imputation methods better identified moderate-severe ARDS (PaO2/FIO2 ≤150); non-linear imputation remained superior (p<0.001). For PaO2/FiO2≤150, the sensitivity and specificity for non-linear imputation were 0.87 (95% CI 0.83–0.90) and 0.91 (95% CI 0.88–0.93) respectively. Skin pigmentation and receipt of vasopressors were not associated with imputation accuracy.
Conclusions
In mechanically ventilated patients, non-linear imputation of PaO2/FIO2 from SpO2/FIO2 appears accurate, especially for moderate-severe hypoxemia. Linear and log-linear imputation cannot be recommended.