Accuracy of Reported Family History of Diabetes Mellitus: Results From San Luis Valley Diabetes Study

Kahn, Louise B.; Marshall, Julie A.; Baxter, Judith; Shetterly, Susan; Hamman, Richard F.

doi:10.2337/diacare.13.7.796

Cited by 45 publications

(39 citation statements)

References 1 publication

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“…Thorand et al (36) stated that this could explain the higher prevalence of maternal history of DM. However, Kahn et al (37) concluded that patients with DM were able to report an accurate family history when carefully questioned. Another possible source of bias is the fact that the life expectancy of men is shorter than that of women, and thus the likelihood of DM diagnosis is higher in women.…”

Section: Discussionmentioning

confidence: 99%

The prevalence of chronic diabetic complications and metabolic syndrome is not associated with maternal type 2 diabetes

Scheffel

Kramer

Rados

et al. 2008

Braz J Med Biol Res

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The maternal history of type 2 diabetes mellitus (DM) has been reported more frequently in patients with type 2 DM than paternal history. The aim of the present study was to determine if there was an association between maternal history of DM and the presence of chronic complications or metabolic syndrome (MetS) in patients with type 2 DM. A cross-sectional study was conducted with 1455 patients with type 2 DM. All outpatients with type 2 diabetes attending the endocrine clinics who fulfilled the eligibility criteria were included. Familial history of DM was determined with a questionnaire. Diabetic complications were assessed using standard procedures. The definition of MetS used was that of the World Health Organization and the National Cholesterol Education Program's Adult Treatment Panel III report criteria. Maternal history of DM was present in 469 (32.3%), absent in 713 (49.1%) and unknown in 273 patients (18.7%). Paternal history of DM was positive in 255 (17.6%), negative in 927 (63.8%) and unknown in 235 patients (16.1%). The frequency of microvascular chronic complications in patients with and without a positive maternal history of DM was similar: diabetic nephropathy (51.5 vs 52.5%), diabetic retinopathy (46.0 vs 41.7%), and diabetic sensory neuropathy (31.0 vs 37.1%). The prevalence of macrovascular chronic complications and MetS was also similar. Patients with type 2 DM were more likely to have a maternal than a paternal history of DM, although maternal history of DM was not associated with an increased prevalence of chronic complications or MetS.

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Section: Discussionmentioning

confidence: 99%

The prevalence of chronic diabetic complications and metabolic syndrome is not associated with maternal type 2 diabetes

Scheffel

Kramer

Rados

et al. 2008

Braz J Med Biol Res

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show abstract

“…Thorand et al (26), investigating the association between DM and parental history among the participants of the MONICA Augsburg Study, reported that "unknown" maternal status was more common than "unknown" paternal status (17.3% versus 8.8%), concluding that the higher prevalence of maternal history could be explained by this bias. However, Kahn et al (27) concluded that patients with DM were able to report an accurate family history when carefully questioned. The present data suggests that this bias had not occurred because the patients answered that did not know the familial history of type 2 DM in a similar frequency to the maternal and paternal line of the family.…”

Section: Discussionmentioning

confidence: 99%

Familial history of type 2 diabetes in patients from Southern Brazil and its influence on the clinical characteristics of this disease

Crispim¹,

Canani

Gross

et al. 2006

Arq Bras Endocrinol Metab

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Objective: To investigate the presence of maternal and paternal history of type 2 diabetes mellitus (DM) in relatives of 644 type 2 diabetic patients from Southern Brazil, and also to evaluate its influence on the clinical characteristics of this disease. Patients and Methods: Familial history of type 2 DM was investigated by a questionnaire. The maternal and paternal history was investigated over two generations. Complete data sets on familial history were obtained from 396 patients. Results: In general, 76.6% of the patients reported at least one first-degree affected relative. Besides, 31.6% of the patients reported a maternal history of type 2 DM and 12.6% reported a paternal history. Patients with maternal and/or paternal history presented a lower age at type 2 DM diagnosis when compared to patients without familial history. In addition, patients with only paternal history presented a higher frequency of hypertension than patients with no familial history. Conclusions: This study suggests that there is a significant maternal effect in the transmission of type 2 DM in Southern Brazil, and that most of the clinical characteristics of this disease do not differ between patients with or without familial history of type 2 DM. Some studies have shown that the adult offspring of diabetic parents are more obese than those of non-diabetic parents and display higher fasting plasma levels of glucose, insulin, triglycerides, total cholesterol and LDL cholesterol (13). Similarly, in Pima Indians, maternal DM is associated with higher blood pressure (BP) in the offspring (14). Recently, a study reported that the offspring of diabetic mothers displayed higher body mass index (BMI) and triglycerides when compared to the offspring of diabetic fathers (15). However, there are still few studies regarding the influence of familial history on the clinical characteristics of type 2 DM, in particular concerning the role of the paternal history on these characteristics.The aims of this study were to compare the prevalence of maternal and paternal history of type 2 DM in patients from Southern Brazil with type 2 DM, and to evaluate the roles of familial histories of DM on the clinical and laboratory characteristics of this disease. PATIENTS AND METHODSThe study group consisted of 644 unrelated type 2 diabetic patients (514 Caucasian-and 130 AfricanBrazilians) participating in a multicenter study in the Brazilian State of Rio Grande do Sul. Diagnosis of type 2 DM was based on the World Health Organization criteria (16). Patients over 30 years old and who had been treated with oral glucose lowering agents for over two years with no history of ketoacidosis were included in the study. Ethnic definition was based on self-report. The Caucasian-Brazilians were descendents from Europeans, mainly from Portugal, Spain, Italy and Germany, whereas the African-Brazilians were descendents from people brought to Brazil, between the 17 th and 18 th centuries, mainly from the west coast of Africa, Angola and Mozambique. Written informed con...

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“…7 In a validation study of family history of diabetes, there was complete agreement between information about diabetic status reported by patients in a clinic and the information given by respective relatives in a follow-up interview. 21 Disease that occurs at earlier ages and results in more severe morbidity will likely be reported more accurately than disease that occurs late in life and is less severe. Diseases for which there may be some stigma, such as schizophrenia or alcoholism, may be reported less reliably.…”

Section: Analytic Validitymentioning

confidence: 99%

Can family history be used as a tool for public health and preventive medicine?

Yoon

Scheuner

Peterson-Oehlke

et al. 2002

Genetics in Medicine

311

258

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Accuracy of Reported Family History of Diabetes Mellitus: Results From San Luis Valley Diabetes Study

Cited by 45 publications

References 1 publication

The prevalence of chronic diabetic complications and metabolic syndrome is not associated with maternal type 2 diabetes

The prevalence of chronic diabetic complications and metabolic syndrome is not associated with maternal type 2 diabetes

Familial history of type 2 diabetes in patients from Southern Brazil and its influence on the clinical characteristics of this disease

Can family history be used as a tool for public health and preventive medicine?

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