Accuracy of Preoperative Biopsies Compared With Surgical Specimens in the Diagnosis of Colorectal Adenocarcinoma

Abstract

The preoperative biopsy of colorectal adenocarcinoma presented good accuracy compared with histopathological examination of the surgical specimen, but with weak to moderate effective degree of agreement between the results.

Endoscopic biopsies from gastrointestinal carcinomas and their suitability for molecular analysis: a review of the literature and recommendations for clinical practice and research

“…Although TP53 was reviewed in both gastric and colorectal carcinoma, and the agreement between EBs and resection specimen was much higher in gastric carcinoma (κ = 0.94 versus κ = 0.22), however, the reported kappa values are not directly comparable as the threshold for scoring TP53 ‘positive’ differed between the studies.…”

“…Eighteen (24%) studies reported the number of EBs used for molecular testing; the median (range) mean number of EBs per patient was 2.1 (1 to 6.6 biopsies) . Only one study reported the location within the tumour from which the biopsy was obtained …”

“…Two studies reported a minimum tumour cell density required in the resection specimen for comparison using cut‐offs of 10% or 50% tumour cells . No association was seen among studies between the mean number of biopsies obtained per patient and the concordance of biomarker testing between biopsy and resection specimen . Results for the different investigative methodologies are detailed below.…”

“…Eighteen (24%) studies reported the number of EBs used for molecular testing; the median (range) mean number of EBs per patient was 2.1 (1 to 6.6 biopsies). [2][3][4][5][6][7][8][9][10][11][12][13][14][15] Only one study reported the location within the tumour from which the biopsy was obtained. 16 Eight (11%) studies included details on the size of the biopsies.…”

“…45 No association was seen among studies between the mean number of biopsies obtained per patient and the concordance of biomarker testing between biopsy and resection specimen. [2][3][4]6,7,[9][10][11][12][13][14][15]20,25,35,36,42,46,47 Results for the different investigative methodologies are detailed below.…”