Accuracy of predictors of perioperative cardiovascular complications in onco-surgery

Соколов, Д. А.; Жбанников, П. С.; Ganert, Andrey N.; Larionov, S. V.; Ljuboshevskij, P. A.

doi:10.17116/anaesthesiology202303137

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…The high percentage of postoperative complications negatively affect patient survival, causing an increase in the volume of research to develop strategies to reduce them [2,3]. Many of these strategies involve the preoperative risk stratification of patients based on metabolic parameters and various biomarkers [4][5][6][7]. Despite numerous cancer studies using metabolomic approaches and promising results, these studies still highlight the heterogeneity of metabolic features and behaviors used by tumor cells that go beyond the simple rewiring of anabolic and catabolic pathways [8].…”

Section: Introductionmentioning

confidence: 99%

Blood Serum and Drainage Microbial and Mitochondrial Metabolites in Patients after Surgery for Pancreatic Cancer

Getsina,

Tsyba,

Polyakov

et al. 2023

Metabolites

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Pancreatic cancer (PC) has the highest mortality rate of all major cancers in the world despite improvements in clinical care and an understanding of the biology of pancreatic cancer. A study of 64 patients with verified pancreatic cancer who underwent surgery was included. Sampling was carried out at three points: before surgery and on days 1–3 after surgery and 5–7 days after surgery. Drainage fluid collection was taken from the drains installed intraoperatively one day after surgery. Tyrosine and phenylalanine metabolites and two mitochondrial metabolites, namely succinic and fumaric acids, were identified and quantified by GC-MS in the serum of healthy donors and patients. Differences in the metabolomic profile were found between the patients and healthy people. A statistically significant decrease in the level of p-hydroxyphenyllactic acid (p-HPhLA), the amount of sum 3 sepsis-associated metabolites (Σ 3AMM), as well as fumaric and succinic acids in patients was observed. It was also noted that p-hydroxyphenyllactic acid in the preoperative period may be considered as a predictor of complications and longer postoperative recovery.

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