Accuracy of positron emission tomography in mediastinal node assessment in coal workers with lung cancer

Saydam, Özkan; Gokce, Mertol; Kılıçgün, Ali; Tanrıverdi, Özgür

doi:10.1007/s12032-011-9879-y

Cited by 20 publications

(24 citation statements)

References 23 publications

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“…The accuracy of FDG-PET/CT in patients with ARLC was within the range reported in the literature. Regarding lung cancer with occupational dust diseases as the underlying disease, the sensitivity, specificity, and accuracy of PET/ CT in patients with lung cancer among coal workers were 84%, 65%, and 74%, respectively (15). The lymph node FP rate in patients with ARLC was lower than that in coal workers with lung cancer (12.2% vs. 35%).…”

Section: Discussionmentioning

confidence: 92%

Assessment of intrathoracic lymph nodes by FDG PET/CT in patients with asbestos-related lung cancer

Iga¹,

Shinmoto²,

Mizuno³

et al. 2021

J Thorac Dis

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Background: This study explored the assessment of intrathoracic lymph node metastasis by 18F-fluoro-2deoxy-D-glucose (FDG) positron emission tomography computed tomography (PET/CT) in patients with asbestos-related lung cancer (ARLC). Methods: We retrospectively reviewed the data on 35 patients with ARLC who underwent preoperative FDG-PET/CT and surgical resection between January 2012 and December 2018. We collected medical information from medical records and imaging systems and examined the FDG uptake in each lymph nodal region resected by surgery and the presence or absence of pathological lymph node metastasis. Results: Pathological lymph node metastases were detected in 14 (8.70%) of 161 nodal stations. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of FDG-PET/CT were 71.4% (10/14), 87.8% (129/147), 35.7% (10/28), 97.0% (129/133), and 86.3% (139/161), respectively.Six of the eight false-positive patients had bilateral accumulations, whereas all six true-positive patients had unilateral accumulation (P=0.006). On histopathological examination, the false-positive nodes showed disruption of lymphoid follicles in the cortex, infiltration of histiocyte-like cells in the medulla, fibrous micronodules, and severe anthracosis. Conclusions: PET/CT scans of patients with ARLC showed comparable sensitivity and specificity to those of PET/CT scans of patients with conventional lung cancer reported in the literature. Many falsepositive cases also showed bilateral symmetric accumulation. This method can be used to evaluate lymph node involvement in lung cancer.

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Section: Discussionmentioning

confidence: 92%

Assessment of intrathoracic lymph nodes by FDG PET/CT in patients with asbestos-related lung cancer

Iga¹,

Shinmoto²,

Mizuno³

et al. 2021

J Thorac Dis

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“…FDG-PET/CT examination for miner workers was reported to be inappropriate because of high false-positive rate for lymph nodes due to pneumoconiosis. 31) Lymph nodes affected by silicosis have an accumulation of moderate FDG in FDG-PET/ CT, and they may be incorrectly evaluated as positive. In FDG-PET/CT, we often feel it is difficult to diagnosis when there is an accumulation of FDG of multiple hilar and mediastinal lymph nodes in lung cancer cases.…”

Section: Resultsmentioning

confidence: 99%

Economic Benefits and Diagnostic Quality of Diffusion-Weighted Magnetic Resonance Imaging for Primary Lung Cancer

Usuda

Funazaki

Maeda

et al. 2017

ATCS

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IntroductionThis paper focuses on the latest research of diffusion-weighted magnetic resonance imaging (DWI), and deals with economic benefits, diagnostic benefits, and prospects of DWI for lung cancer. The medical cost of a magnetic resonance imaging (MRI) is 81%-84% cheaper than that of 18-fluoro-2-deoxy-glucose positron emission tomography/computed tomography (FDG-PET/CT). DWI is reported to be useful for differential diagnosis of malignancy or benignity for neoplasm in various organs. Diagnostic efficacy by DWI for pulmonary nodules and masses and the evaluation of N factor and M factor in lung cancer are equivalent to or more than that of FDG-PET/CT. The diagnostic capability of wholebody DWI (WB-DWI) for the staging of clinically operable lung cancers is equivalent to that of FDG-PET/CT and brain MRI, and WB-DWI is now becoming a more main stream procedure. Although the diagnostic performance of DWI for lung cancer may be equivalent to that of FDG-PET/CT, prospective randomized controlled trial for comparison of diagnostic efficacy between FDG-PET/CT and DWI for lung cancer is necessary for an accurate comparison. DWI may have an advantage in the aspect of the cost and diagnostic efficacy in lung cancer management.

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“…This is especially the case in patients suffering from pneumoconiosis [29][30][31] . Consequently, histological confirmation of abnormal lymph nodes on PET/CT is important in many cases, too.…”

Section: Discussionmentioning

confidence: 99%

Mediastinal lymph node staging by EBUS-TBNA and CT: Characteristics of lymph node enlargement caused by anthracosis and other benign conditions

Kirchner

Broll

Müller

et al. 2014

IJDI

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Objectives: Aim of this comparative study was to assess the accuracy of computed tomography (CT) and endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) for mediastinal lymph node staging in cases of lymph node enlargement due to anthracosis and other benign conditions. Methods:In a retrospective analysis we report on the MSCT findings of 39 patients (28 males, 11 females) with EBUS-TBNA confirmed diagnosis of 53 enlarged lymph nodes due to anthracosis. A control group comprised 20 consecutive patients with 27 enlarged lymph nodes (11 males, 9 females) due to chronic lymphadenopathy (n = 14) or sarcoidosis (n = 13).Results: No significant differences were observed between the two groups regarding size (mean short axis diameter 13.7mm vs. 14.5mm), shape (most often oval) or presence of lymph node confluence (32.1% vs. 33.3%), contrast enhancement (3.8% vs. 3.7%), and fatty involution (3.8% vs. 3.7%). In comparison with the control group anthracotic lymph nodes were significantly less often ill-defined in EBUS (5.7 vs. 25.9, p = 0.025) as well as in CT (1.9% vs. 18.5%, p = 0.01), but more often showed calcifications in CT (24.5% vs. 3.7%, p = 0.017). Lymph node colliquation was seen neither in anthracosis nor in other benign conditions. Conclusions:Mediastinal lymph node enlargement due to anthracosis, lymphadenopathy and sarcoidosis show some different findings in EBUS and CT but cannot definitely be differentiated. Advances in knowledge:Radiologists should be aware of mediastinal lymph node enlargement due to anthracosis.

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Accuracy of positron emission tomography in mediastinal node assessment in coal workers with lung cancer

Cited by 20 publications

References 23 publications

Assessment of intrathoracic lymph nodes by FDG PET/CT in patients with asbestos-related lung cancer

Assessment of intrathoracic lymph nodes by FDG PET/CT in patients with asbestos-related lung cancer

Economic Benefits and Diagnostic Quality of Diffusion-Weighted Magnetic Resonance Imaging for Primary Lung Cancer

Mediastinal lymph node staging by EBUS-TBNA and CT: Characteristics of lymph node enlargement caused by anthracosis and other benign conditions

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