Accuracy of positron emission tomography and computed tomography (PET/CT) in detecting nodal metastasis according to histology of non-small cell lung cancer

Smith, David; Aramburu, Julian Fernandez; Lozzo, Alejandro Gabriel Da; Montagne, Juan; Beveraggi, Enrique; Dietrich, Alexander

doi:10.1007/s13304-019-00680-x

Cited by 7 publications

(7 citation statements)

References 19 publications

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“…The effect of histological type in identifying the incidence of OLNM is still under debate. In the same study, younger age and higher tumor size value were proved to be risk factors of OLNM, which showed no significant differences in other research [18][19][20][21]. To conclude, the research on the incidence of OLNM has not arrived at a consensus.…”

Section: Discussionmentioning

confidence: 77%

“…PET/CT had been proved effective in predicting OLNM among early T-stage patients with adenocarcinoma or squamous cell carcinoma [18]. Further, PET- CT presented an overall sensitivity and specificity of 93.8% and 62.7% in a previous single-center retrospective study, proving PET-CT to be a reliable screening test rather than a diagnosis test [19]. As another earlier retrospective cohort study reported, if preoperative SUV max value of PET-CT is greater than 5, OLNM is more likely to occur [20].…”

Section: Discussionmentioning

confidence: 95%

“…Apart from the prognostic research on imaging factors, many previous studies focused on patient histology. Micropapillary components and squamous cell carcinoma have been identified as important prognostic factors in past research [19,20], although another retrospective study reported no significant association between histological type and the occurrence of OLNM [21]. The effect of histological type in identifying the incidence of OLNM is still under debate.…”

Section: Discussionmentioning

confidence: 99%

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Predicting Occult Lymph Node Metastasis by Nomogram in Patients with Lung Adenocarcinoma ≤2 cm

Wang

et al. 2021

Future Oncol.

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Background: Previous researches had not proposed any prediction models for occult lymph node metastasis (OLNM). Considering the occurrence of OLNM and the importance of OLNM management, we aimed to develop a nomogram to predict OLNM of patients with lung adenocarcinoma ≤2 cm. Methods: Characteristics of patients with lung adenocarcinoma of ≤2 cm diameter at the Peking Union Medical College Hospital were retrospectively reviewed. Univariate and multivariate logistic regressions were performed. A nomogram model was developed. The concordance index (C-index) and calibration and decision curves were used to evaluate the predictive ability. Results: A total of 473 patients were enrolled, with an OLNM incidence of 7.4%. Four factors were selected as risk factors. The model had a C-index of 0.932. Calibration and decision curves were determined. Conclusion: Patients with pure ground-glass opacity (pGGO) or noninvasive adenocarcinoma have significantly lower risk of OLNM. SUVmax, CEA, micropapillary and solid component were identified as independent risk factors. The nomogram model was effective in predicting OLNM preoperatively.

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

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Predicting Occult Lymph Node Metastasis by Nomogram in Patients with Lung Adenocarcinoma ≤2 cm

Wang

et al. 2021

Future Oncol.

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“…6 PET-CT imaging can reflect not only the anatomical information of lesions, but also the biological activity of tumor lesions, so PET-CT is the gold standard to determine the tumor staging of lung cancer. 7 In addition, PET-CT also has a superiority in the diagnosis of lymph node metastasis of lung cancer. 8 Current studies are more inclined to CT and PET-CT in the evaluation of primary lesions, but rarely investigate mediastinal lymph nodes.…”

Section: Introductionmentioning

confidence: 99%

Clinical evaluation of contrast-enhanced CT combined with PET/CT in diagnosis of mediastinal lymph node metastasis of non-small-cell lung cancer

Li¹,

Zheng

Zhang³

et al. 2022

Pak J Med Sci

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Objectives: To investigate the clinical value of contrast-enhanced CT combined with PET/CT in the differential diagnosis of mediastinal lymph node metastasis (MLNM) of non-small-cell lung cancer (NSCLC). Methods: A total of 120 patients with NSCLC combined with mediastinal lymphadenopathy hospitalized in our hospital were selected. All the patients received radical resection of lung cancer and mediastinal lymphadenectomy. After pathological diagnosis, they were divided into MLNM group (malignant group, undergoing contrast-enhanced CT) and non-MLNM group (benign group, receiving contrast-enhanced CT combined with PET-CT). The results were judged by two senior radiologists independently. The results of different scanning methods and postoperative pathology were compared using the t test, χ2 test and Pearson correlation coefficient test. Results: Compared with the pathological results, contrast-enhanced CT diagnosed 31 cases, with a coincidence rate of 62%, and contrast-enhanced CT combined with PET-CT diagnosed 42 cases, with a coincidence rate of 84%, presenting a statistically significant difference (P = 0.02). Among the 120 patients with lung cancer, pathological examination confirmed MLNM in 50 patients and benign enlargement in 70 patients, contrast-enhanced CT alone detected metastasis in 40 patients and benign enlargement in 80 patients, and contrast-enhanced CT combined with PET-CT detected metastasis in 47 patients and benign enlargement in 73 patients. The sensitivity and accuracy of the latter were significantly higher than those of the former (sensitivity, P = 0.01; accuracy, P = 0.01). With the increase in the malignancy of lymph nodes, the degree of CT enhancement, the concentration of radioactive substances and SUV value increased, showing positive correlations. Conclusion: Contrast-enhanced CT combined with PET/CT in the diagnosis of MLNM of NSCLC presents higher coincidence rate, sensitivity and accuracy. With the increase in tumor malignancy, the enhancement degree and radioactive substance concentration increase. The two methods are synergistic and complementary in diagnosing MLNM. doi: https://doi.org/10.12669/pjms.38.5.5528 How to cite this:Li X, Zheng X, Zhang T, Dong X, Su J. Clinical evaluation of contrast-enhanced CT combined with PET/CT in diagnosis of mediastinal lymph node metastasis of non-small-cell lung cancer. Pak J Med Sci. 2022;38(5):---------. doi: https://doi.org/10.12669/pjms.38.5.5528 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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“…5 Parimon et al 6 reported that patients with chronic obstructive pulmonary disease (COPD) who were treated with inhaled corticosteroids had a reduced incidence of lung cancer and death, suggesting that the inhibition of inflammation can prevent lung tumorigenicity. 18 F-fluorodeoxyglucose positron emission tomography/ computed tomography ( 18 F-FDG PET/CT) is useful in detecting and staging malignant tumors [7][8][9] and has been used to study inflammatory disease 10,11 based on the increased glucose utilization of malignant or inflammatory tissue. Although there are a few studies exploring lung standardized uptake value (SUV) in normal tissue, 12,13 they focused on the differences in lung SUV based on anatomical location rather than on smoking history.…”

Section: Introductionmentioning

confidence: 99%

The Association Between Lung Fluorodeoxyglucose Metabolism and Smoking History in 347 Healthy Adults

Tong¹,

Sui²,

Jiang³

et al. 2021

JAA

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This study aimed to evaluate the relationship between fluorodeoxyglucose metabolism and smoking history in healthy adults by analyzing lung standardized uptake value (SUV). Methods: The 18 F-fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) studies of 347 patients who did not show signs of having malignant diseases or lung inflammation were retrospectively evaluated. Four circular regions of interest (ROI) were manually drawn on the upper and lower lung regions. The averages of maximum SUV (SUVmax-avr) and mean SUV (SUVmean-avr) were calculated, and the mean values of each parameter for non-smokers, ex-smokers, and current smokers were compared. The correlation between SUVmax-avr and smoking history (tobacco burden and the duration of smoking cessation) was assessed based on present smoking status. The exsmokers and current smokers were divided into three groups according to their tobacco burden, and the SUVmax-avrs of the two groups were compared. Results: Both the mean values of SUVmax-avr and SUVmean-avr increased based on smoking history, with non-smokers having the lowest values and current smokers the highest. Tobacco burden had a positive correlation with SUVmax-avr in current smokers (r = 0.474, P< 0.001). However, neither tobacco burden (r = 0171, P = 0.162) nor duration of smoking cessation (r = 0.212, P = 0.082) had a significant correlation with SUVmax-avr in ex-smokers. The mean SUVmax-avr of current smokers was significantly higher than that of ex-smokers in patients with a medium or large tobacco burden (P = 0.012, P< 0.001, respectively). Although there was no significant difference between the mean SUVmax-avrs of ex-smokers and current smokers in patients with a small tobacco burden (P = 0.888), the mean SUVmax-avrs of both ex-smokers and current smokers with a small tobacco burden were significantly higher than that of nonsmokers (P< 0. 001, P< 0.001, respectively). Conclusion:The findings indicate that lung SUV increases in current heavy smokers and partially decreases after the cessation of smoking, which is in line with previous reports studied by analyzingfluorodeoxyglucose (FDG) metabolism of lung specimens.

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Accuracy of positron emission tomography and computed tomography (PET/CT) in detecting nodal metastasis according to histology of non-small cell lung cancer

Cited by 7 publications

References 19 publications

Predicting Occult Lymph Node Metastasis by Nomogram in Patients with Lung Adenocarcinoma ≤2 cm

Predicting Occult Lymph Node Metastasis by Nomogram in Patients with Lung Adenocarcinoma ≤2 cm

Clinical evaluation of contrast-enhanced CT combined with PET/CT in diagnosis of mediastinal lymph node metastasis of non-small-cell lung cancer

The Association Between Lung Fluorodeoxyglucose Metabolism and Smoking History in 347 Healthy Adults

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