Accuracy of Patients' Reports of Comorbid Disease and Their Association With Mortality in ESRD

Cavanaugh, Kerri L.; Merkin, Sharon Stein; Plantinga, Laura C.; Fink, Nancy E.; Sadler, John H.; Powe, Neil R.

doi:10.1053/j.ajkd.2008.02.001

Cited by 40 publications

(29 citation statements)

References 32 publications

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“…Among the limitations of our study is that history of diabetes was self-reported. However, diabetes is a serious chronic condition and it has been reliably recalled in other epidemiological studies [49,50]. Furthermore, it is possible that self-reported information on medical conditions is reported more accurately in cases than in population-controls, but not necessarily in hospital-controls [49].…”

Section: Discussionmentioning

confidence: 99%

Diabetes, antidiabetic medications, and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Diabetes, antidiabetic medications, and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium

et al. 2014

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“…There was strong evidence supporting the reliability and validity of self-reported diabetes mellitus, where agreement between self-reported disease diagnosis and medical conditions was observed. 55–57 In addition, several studies reported high correlations between recalled and measured weight and height in young adulthood among middle-aged and older men and women. 58–62 …”

Section: Discussionmentioning

confidence: 99%

Obesity Early in Adulthood Increases Risk but Does Not Affect Outcomes of Hepatocellular Carcinoma

et al. 2015

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BACKGROUND & AIMS Despite the significant association between obesity and several cancers, it has been difficult to establish an association between obesity and hepatocellular carcinoma (HCC). Patients with HCC often have ascites, making it a challenge to accurately determine body mass index (BMI), and many factors contribute to the development of HCC. We performed a case–control study to investigate whether obesity early in adulthood affects risk, age of onset, or outcomes of patients with HCC. METHODS We interviewed 622 patients newly diagnosed with HCC from January 2004 through December 2013, along with 660 healthy controls (frequency-matched by age and sex) to determine weights, heights, and body sizes (self-reported) at various ages before HCC development or enrollment as controls. Multivariable logistic and Cox regression analyses were performed to determine the independent effects of early obesity on risk for HCC and patient outcomes, respectively. BMI was calculated, and patients with a BMI ≥30 kg/m2 were considered obese. RESULTS Obesity in early adulthood (age, mid-20s to mid-40s) is a significant risk factor for HCC. The estimated odds ratios (OR) and 95% confidence intervals (CI) were 2.6 (1.4–4.4), 2.3 (1.2–4.4), and 3.6 (1.5–8.9) for the entire population, men, and women, respectively. Each unit increase in BMI at early adulthood was associated with a 3.89-month decrease in age at HCC diagnosis (P<.001). Moreover, there is a synergistic interaction between obesity and hepatitis virus infection. However, we found no effect of obesity on the overall survival of patients with HCC. CONCLUSION Early adulthood obesity is associated with increased risk of developing HCC at a young age in the absence of major HCC risk factors, with no effect on outcomes of patients with HCC.

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“…Consistent with the published literature (2), patients with diabetes mellitus and patients with nasal carriage of S. aureus upon study entry were at a higher risk of infection. The high prevalence of both risk factors at baseline underscore their importance for patients with ESRD (20,21). This study is also consistent with previous studies showing that patients with synthetic or heterologous tissue grafts are at higher risk of S. aureus infection than patients with arteriovenous fistulas (22).…”

Section: Discussionmentioning

confidence: 99%

Outcomes of Staphylococcus aureus Infection in Hemodialysis-Dependent Patients

Friedman

O’Neal

et al. 2009

Clinical Journal of the American Society of Nephrology

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Background and objectives: Staphylococcus aureus is a leading cause of infection in patients with ESRD. Clinical and economic outcomes associated with S. aureus bacteremia and other S. aureus infections in patients with ESRD were examined.Design, setting, participants, & measurements: Laboratory, clinical, and hospital billing data from a randomized trial of 3359 hemodialysis-dependent patients hospitalized with S. aureus infection in the United States whose vascular access type was fistula or graft and who were hospitalized with S. aureus infection to evaluate inpatient costs, hospital days, and mortality over 12 wk were used. Generalized linear regression was used to identify independent predictors of 12-wk costs, inpatient days, and mortality.Results: Of the 279 patients (8.3%) who developed S. aureus infection during approximately 1 yr of follow-up, 25.4% were treated as outpatients. Among patients for whom billing data were available, 89 patients hospitalized with S. aureus bacteremia incurred mean 12-wk inpatient costs of $19,454 and 11.9 inpatient days. Among the 70 patients hospitalized with non-bloodstream S. aureus infections, mean inpatient costs were $19,222 and the mean number of inpatient days was 11.3. Twelve-week mortality was 20.2 and 15.7% for patients with S. aureus bloodstream and non-bloodstream infections, respectively. Older age was independently associated with higher risk of death among patients with S. aureus bacteremia and with higher inpatient costs and more hospital days among patients with non-bloodstream infections.Conclusions: Hemodialysis-dependent patients with fistula or graft access incur high costs and long inpatient stays when hospitalized for S. aureus infection.

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Accuracy of Patients' Reports of Comorbid Disease and Their Association With Mortality in ESRD

Abstract: Background-Patient awareness of chronic diseases is low. Unawareness may represent poor understanding of chronic illness and may be associated with poor outcomes in end-stage renal disease (ESRD) patients.

Cited by 40 publications

References 32 publications

Diabetes, antidiabetic medications, and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium

Diabetes, antidiabetic medications, and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium

Obesity Early in Adulthood Increases Risk but Does Not Affect Outcomes of Hepatocellular Carcinoma

Outcomes of Staphylococcus aureus Infection in Hemodialysis-Dependent Patients

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