Accuracy of minor salivary gland biopsy in the diagnosis of Sjögren syndrome

Edelstein, Robert A.; Kilipiris, G E; Macháleková, Katarína; Mouzalini, E; Slobodianuk, A; Javorka, V.

doi:10.4149/bll_2021_075

Cited by 4 publications

(3 citation statements)

References 35 publications

(38 reference statements)

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“…(4) For our patients, the most frequent comorbid rheumatic disease was RA (16), followed by 1 patient with SLE and 1 patient with scleroderma. A study of 50 saliva biopsies by Edelstein et al (9) diagnosed SS in 39 patients, and of these 11 were classified as secondary SS (28% secondary SS, 72% primary SS). The most common rheumatic disease accompanying secondary SS was RA for 7 patients, similar to our study.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and results of patients who underwent minor salivary gland biopsy with the suspicion of Sjogren syndrome

Kutluk

Çay

2023

Preprint

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OBJECTIVES: To evaluate the value and accuracy of biopsy in diagnosing Sjogren's syndrome (SS) by evaluating the results of patients who underwent minor salivary gland biopsy (MSGB) with the suspicion of SS. MATERIALS and METHODS: The study was planned with retrospective assessment of 127 patients with biopsy performed for SS diagnosis. The clinical and laboratory characteristics of the patients who underwent MSGB were recorded from their files. SS diagnosis was placed using the rating system according to 2016 ACR/EULAR classification criteria or based on expert opinion. RESULTS: 113 patients met the inclusion criteria. 72 patients diagnosed with SS. 56 were diagnosed according to the 2016 ACR/EULAR classification criteria and 16 were diagnosed according to expert opinion. There were 57 patients with positive MSGB outcome (55 SS, 2 not SS). There were 56 patients with MSGB negative outcome (17 SS, 39 not SS). The sensitivity of MSGB for SS diagnosis was 76.4%, and specificity was 95.1%. CONCLUSION: All of our patients had antibody test results, but the number of objective tests included in the classification criteria such as salivary flow rate and Schirmer was low. Although MSGB is considered an invasive technique, it appears to be a safe technique as long as it is performed by experienced professionals. It will assist in the final decision for patients with SS suspicion and who cannot undergo other objective tests. KEY WORDS: Sjogren syndrome, diagnosis, minor salivary gland biopsy

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Section: Discussionmentioning

confidence: 99%

Clinical characteristics and results of patients who underwent minor salivary gland biopsy with the suspicion of Sjogren syndrome

Kutluk

Çay

2023

Preprint

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“…Biopsy is a surgical procedure performed to collect a portion of tissue or organ for diagnostic studies, which must be properly preserved and processed through marking systems and then histopathologically examined [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

“…Salivary gland biopsy can be performed to diagnose diseases of salivary parenchyma, such as degenerative and inflammatory diseases, or amyloidosis and sarcoidosis [ 2 ]. This biopsy can be performed using simple and minimally invasive methods, such as minor salivary gland biopsy (MSGB); in particular, lower lip mucosa is considered to be the least invasive collection site for the collection of an adequate diagnostic sample [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Current Salivary Glands Biopsy Techniques: A Comprehensive Review

et al. 2022

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Biopsy is a surgical procedure performed to collect a portion of tissue or organ for diagnostic studies. The aim of the present manuscript is to describe state-of-the-art major and minor salivary gland biopsy techniques and assess the indications and complications of other salivary gland biopsy techniques. A search was performed using the following MeSH terms: biopsy, fine-needle biopsies, image-guided biopsies, frozen sections, and salivary glands disease. A current overview of major and minor salivary glands biopsy techniques was provided. In the oncological field, a comparison was made between the most widely used biopsy method, ultrasound-guided fine-needle aspiration biopsy (US-FNAB), and an alternative method, ultrasound-guided core needle biopsy (US-guided CNB), highlighting the advantages and disadvantages of each. Finally, intra-operative frozen sections (IOFSs) were presented as an additional intraoperative diagnostic method. Minor salivary gland biopsy (MSGB) is the simplest diagnostic method used by clinicians in the diagnosis of inflammatory and autoimmune diseases. In neoplastic lesions, US-FNAB represents the most performed method; however, due to its low diagnostic accuracy for non-neoplastic specimens, US-guided CNB has been introduced as an alternative method.

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Usefulness of Unstimulated and Stimulated Whole Saliva, Accuracy of Minor Labial Salivary Gland Biopsy in the Diagnosis of Primary Sjögren's Disease: A Croatian Single-Center, Cross-Sectional Study

Baric,

Tadin,

Glavina

2023

Galician med. j.

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The aim of this cross-sectional study was to determine the accuracy of minor labial salivary gland (MLSG) biopsy in the diagnosis of primary Sjögren' s disease (pSD); to study the correlation between the focus score (FS) and anti-SSA/Ro, anti-SSB/La, anti-SSA and -SSB antibodies, unstimulated whole saliva (UWS) and stimulated whole saliva (SWS); to determine the role of UWS and SWS in the clinical evaluation of pSD patients and patients with sicca symptoms. Methods. A total of 37 subjects were enrolled in the study and divided into two groups: the test group consisted of 15 patients diagnosed with pSD; the control group consisted of 22 patients who had sicca symptoms but did not meet the 2016 American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR) diagnostic criteria. Clinical and laboratory tests, including saliva collection, MLSG biopsy, autoantibody titers, were performed in all patients. Results. The median of the FS was 1.00 [IQR=1.00-1.50] in the test group, whereas in the control group, it was 0.00 [IQR=0.00-0.00] (p< 0.001). The sensitivity, specificity, and accuracy of MLSG biopsy were 86.7%, 100.0%, and 94.6%, respectively. The results showed a correlation between the FS and antinuclear antibodies (ANA) (p=0.002). In addition, Pearson’s correlation showed a weak negative correlation between UWS (r=-0.058, p=0.73) and SWS (r=-0.022, p=0.90) and the FS. In the test group, 73.3% of patients had abnormal UWS values, while 86.7% had abnormal SWS values; among them, values of 0.00 ml/min for UWS and SWS were found in 60.0% and 26.7% of patients, respectively. Conclusions. Although MLSG biopsy has great diagnostic value and accuracy in diagnosing pSD, it is not always definitive. Our study found a statistically significant association between the FS and ANA, and the greater utility of SWS in diagnosing pSS.

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Accuracy of minor salivary gland biopsy in the diagnosis of Sjögren syndrome

Cited by 4 publications

References 35 publications

Clinical characteristics and results of patients who underwent minor salivary gland biopsy with the suspicion of Sjogren syndrome

Clinical characteristics and results of patients who underwent minor salivary gland biopsy with the suspicion of Sjogren syndrome

Current Salivary Glands Biopsy Techniques: A Comprehensive Review

Usefulness of Unstimulated and Stimulated Whole Saliva, Accuracy of Minor Labial Salivary Gland Biopsy in the Diagnosis of Primary Sjögren's Disease: A Croatian Single-Center, Cross-Sectional Study

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