Accuracy of micro powder dosing via a vibratory sieve–chute system

Besenhard, Maximilian O.; Faulhammer, Eva; Fathollahi, Sara; Reif, G.; Calzolari, Vittorio; Biserni, Stefano; Ferrari, Arlen; Lawrence, Simon; Llusa, Marcos; Khinast, Johannes G.

doi:10.1016/j.ejpb.2015.04.037

Cited by 18 publications

(12 citation statements)

References 42 publications

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“…In this study, two powders (hereinafter referred to as powder I and powder II) of inhalation-grade α-lactose monohydrate with different particle sizes and supplied by different manufacturers (DFE Pharma, Goch, Germany and Meggle, Wasserburg am Inn, Germany), as received. The same powders were used in our previous work [14], which contains a detailed description of the characterization procedures. Since new powder samples, i.e., new batches, were provided for this study, powder properties were characterized again (see Table 2, the results are in good agreement with [14]).…”

Section: Methodsmentioning

confidence: 99%

“…The same powders were used in our previous work [14], which contains a detailed description of the characterization procedures. Since new powder samples, i.e., new batches, were provided for this study, powder properties were characterized again (see Table 2, the results are in good agreement with [14]). Properties not mentioned in [14] were determined as described below.…”

Section: Methodsmentioning

confidence: 99%

“…Hence, microdosing systems can serve as micro feeders based on the feeding requirements. As discussed in [14], dosing of small powder entities is relevant in the field of granular 3D printing that became state-of-the-art in the recent years [15] [16].…”

Section: Introductionmentioning

confidence: 99%

“…While our earlier work [14] focused on micro dosing of capsules via a vibratory sieve-chute system, the current one addresses the micro feeding properties of such a system. The feeder was tested in terms of feasible feed rates, feed robustness and reproducibility.…”

Section: Introductionmentioning

confidence: 99%

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Continuous feeding of low-dose APIs via periodic micro dosing

Besenhard

Karkala

Faulhammer

et al. 2016

International Journal of Pharmaceutics

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Precise and effective feeding of small powder quantities remains a challenge in many fields, including pharmaceutical development and production. This paper demonstrates that a simple feeding principle can be applied to accomplish stable micro feeding (<100mg/s) and describes a gravimetric powder feeding system with a vibratory sieve mounted on a chute. Feeding was induced via vertical vibrations that can be adjusted within a broad range of frequencies and amplitudes. The feeding system was studied using different frequencies, amplitudes, sieves and powder properties. Feeding was characterized by means of a dynamic scale and high-speed camera recordings. The feeding system provided effective powder feeding even in a range of 1-2mg/s. It was shown that powder properties require special attention when the vibratory sieve-chute system operates at higher feed rates (or feeding times >30min), i.e., feeding at a higher throughput. A combination of discrete element method (DEM) simulations and compartment population balance model (PBM) was used to incorporate the proposed micro feed system into a continuous powder mixer (Gerike GCM250; Gerike Holding LTD., Regensdorf, Switzerland). It illustrates how oscillating feeding rates (the latter is a characteristic of the studied micro feeding system) affect the content uniformity of low dose blends, i.e., powder mixtures with a relatively low fraction of active pharmaceutical ingredient.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Continuous feeding of low-dose APIs via periodic micro dosing

Besenhard

Karkala

Faulhammer

et al. 2016

International Journal of Pharmaceutics

Self Cite

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“…Particles of this size are rather cohesive, show poor flow properties and are generally administered in very low doses, i.e., in the range of a few micrograms. Thus, the handling and processing is rather difficult (Besenhard et al, 2015;Daniher and Zhu, 2008;Faulhammer et al, 2014a). In order to improve the flowability and dosing accuracy and to minimize dose variability, carrier-based formulations are used (Jones and Price, 2006).…”

Section: Introductionmentioning

confidence: 99%

Carrier-based dry powder inhalation: Impact of carrier modification on capsule filling processability and in vitro aerodynamic performance

Faulhammer

Wahl

Zellnitz

et al. 2015

International Journal of Pharmaceutics

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Comparative Study of a Novel Micro-feeder and Loss-in-weight Feeders

2021

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Purpose Accurate and reliable feeding of small quantities of powder is crucial in many industries. It is particularly true in the case of pharmaceutical manufacturing. First, the exact dosage of highly potent active pharmaceutical ingredients (APIs) is essential. Second, due to the shift towards continuous manufacturing, processing agents must be supplied continuously. Last, with regard to personalized medicine products, small doses of API have to be processed with high flexibility. In all these applications, a few grams of powder or less per hour have to be fed, which makes processing very challenging. The common route of pre-blending causes additional effort in processing and quality control compared to direct continuous feeding, while material properties influence the performance of conventional feeders with conveying screw elements. Methods In this study, a novel micro-feeding system based on active volumetric displacement is investigated and compared to commercial LIW feeders of various scales. In the micro-feeder, the powder is filled into a cylindrical cartridge and pushed towards the process by a piston in a controlled manner. Tests are carried out with a free-flowing grade of lactose and croscarmellose sodium as an example of cohesive powder. Results At feed rates of a few grams per hour, for the investigated materials, the system has at least the same performance as conventional feeders at significantly higher feed rates. Especially at low feed rates, less fluctuations are obvious and accuracy and precision of the micro-feeder are at the same level as for the established feeding technology at rates ten times higher. Conclusion For the two types of investigated materials (free-flowing and cohesive), the micro-feeding system shows similar or better performance than conventional and commercially applied LIW feeders. The technology offers the potential for highly accurate, continuous feeding in the low-dose range.

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Accuracy of micro powder dosing via a vibratory sieve–chute system

Cited by 18 publications

References 42 publications

Continuous feeding of low-dose APIs via periodic micro dosing

Continuous feeding of low-dose APIs via periodic micro dosing

Carrier-based dry powder inhalation: Impact of carrier modification on capsule filling processability and in vitro aerodynamic performance

Comparative Study of a Novel Micro-feeder and Loss-in-weight Feeders

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